Transfusion Safety Study (TSS)
Primary Purpose
Acquired Immunodeficiency Syndrome, Blood Transfusion, HIV Infections
Status
Completed
Phase
Locations
Study Type
Observational
Intervention
Sponsored by
About this trial
This is an observational trial for Acquired Immunodeficiency Syndrome
Eligibility Criteria
No eligibility criteria
Sites / Locations
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00005301
First Posted
May 25, 2000
Last Updated
April 14, 2016
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
1. Study Identification
Unique Protocol Identification Number
NCT00005301
Brief Title
Transfusion Safety Study (TSS)
Study Type
Observational
2. Study Status
Record Verification Date
August 2001
Overall Recruitment Status
Completed
Study Start Date
September 1984 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
February 1998 (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
4. Oversight
5. Study Description
Brief Summary
To evaluate factors influencing the risk of transfusion-transmitted human immunodeficiency virus (HIV) infection and its progression to clinically significant manifestations.
Detailed Description
BACKGROUND:
In the summer of 1981, the Centers for Disease Control (CDC) alerted the medical community to an unexpected outbreak of Pneumocystis carinii pneumonia and Kaposi's sarcoma in young homosexual men, individuals not known to be at risk for these uncommon diseases. Studies of immunologic functions in these patients demonstrated lymphopenia, cutaneous anergy, reduced helper T-lymphocyte (T4) subpopulations, depressed ratios of helper T-lymphocytes to suppressor T-lymphocytes (T4:T8), abnormal lymphocyte responses to mitogen stimulation, decreased natural killer-cell activity, and often hypergammaglobulinemia. The name of acquired immunodeficiency syndrome (AIDS) was given to this disorder of immunologic regulation with opportunistic infections or Kaposi's sarcoma or both.
Since that time, AIDS was reported in patients with hemophilia and in others receiving blood transfusions. The NHLBI was delegated responsibility for studies to elucidate, through a systematic prospective study, the possible association of blood product use with AIDS. The incidence of transfusion-acquired AIDS was so low as to preclude a general prospective study of transfusion recipients to determine the overall incidence of the disease. By focusing on patient groups that appeared to have a higher likelihood for developing AIDS because they required chronic, repeated transfusion therapy, information about the epidemiology of the disorder could be more readily obtained. Continuing medical evaluation of these patients from apparent high-risk groups in a prospective fashion allowed identification of significant emerging physiologic alterations and to follow the time-course of pathologic developments.
The purpose of this study was to develop a clear picture of what immunologic changes occurred in patients who were transfused and to determine when these changes occurred and how long they lasted. Since most of the patient population was heavily transfused, some of the study subjects eventually developed AIDS. Information obtained during the study about these patients was then used to answer such questions as: Which factors determined a particular person's risk of developing AIDS and to what degree? What alterations occurred before the clinical manifestations of AIDS? Was progression from normal to defective cell-mediated immunity to AIDS strictly unidirectional or did altered cell-mediated immunity in the study cohort ever regress to normality? If progression was not unidirectional, what determined the outcome? Also, the importance of establishing a serum and cell repository could not be overemphasized, since, as new scientific information became available, these specimens enabled the performance of a number of different retrospective studies.
In 1984 a serum repository for HIV testing was established. The task of the repository was to collect and store serum samples from blood donors in four blood transfusion units located in four major risk areas for AIDS, namely New York, San Francisco, Miami, and Los Angeles. Blood was obtained from the New York Blood Center in New York City, the Irwin Memorial Blood Bank in San Francisco, the Red Cross in Los Angeles, and the American Red Cross, South Florida Region, in Miami. The purpose of the repository was to determine the outcome of the transfusion of blood components retrospectively found to show HIV infection of the donor. The collected sera were separated, indexed, frozen, and stored.
In 1984 the second part of the Transfusion Safety Study, the prospective study, was initiated by NHLBI under a separate request for proposal. The testing of the 201,000 serum specimens in the donor repository for antibody to HIV was carried out by laboratories in the prospective study. Those donors confirmed to be anti-HIV positive and matching donors confirmed to be anti-HIV negative were recruited as TSS subjects. Recipients of blood from the positive donors and the negative donors were also recruited as subjects.
In September 1984, the TSS began a nine month planning phase during which the protocols and data systems for the prospective study were developed. Subjects were entered in July 1985 through June 1989. Analysis continued through November 1997. There were clinical centers in Los Angeles, San Francisco, New York City, and Miami. The coordinating center was at the University of Southern California. The central laboratories including the immunological standardization laboratory, the immunological reagents laboratory, and the central processing laboratory were located in Los Angeles, with one of the immunology laboratories located in Seattle, Washington at the Puget Sound Blood Center.
DESIGN NARRATIVE:
At baseline, each subject received a physical examination, was questioned as to medical history, and gave blood samples for immunologic and other studies. Each subject returned at a specified interval for a repeat of studies specified in the protocol. Blood studies included complete blood cell count, characterization of immunologic cells such as T- and B-lymphocytes and natural killer-cells. Plasma and Buffy coat cell suspensions were stored frozen. Alanine aminotransferase levels were determined. Serologic tests were performed for hepatitis, Epstein-Barr virus, and cytomegalovirus. Markers of immune status, including immune globulin levels were measured. The study ended in November, 1997.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acquired Immunodeficiency Syndrome, Blood Transfusion, HIV Infections
7. Study Design
10. Eligibility
Sex
Male
Maximum Age & Unit of Time
100 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
No eligibility criteria
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
James Mosley
12. IPD Sharing Statement
Citations:
PubMed Identifier
3608439
Citation
Niland-Weiss J, Azen SP, Odom-Maryon T, Lui F, Hagerty C. A microcomputer-based distributed data management system for a large cooperative study of transfusion associated acquired immunodeficiency syndrome. Comput Biomed Res. 1987 Jun;20(3):225-43. doi: 10.1016/0010-4809(87)90056-5.
Results Reference
background
PubMed Identifier
3113759
Citation
Fletcher MA, Baron GC, Ashman MR, Fischl MA, Klimas NG. Use of whole blood methods in assessment of immune parameters in immunodeficiency states. Diagn Clin Immunol. 1987;5(2):69-81.
Results Reference
background
PubMed Identifier
3686662
Citation
Perkins HA, Cordell R, Bueno C, Shiota J, Hitchcock B. The progressive decrease in the proportion of blood donors with antibody to the human immunodeficiency virus (HIV). Transfusion. 1987 Nov-Dec;27(6):502-3. doi: 10.1046/j.1537-2995.1987.27688071706.x. No abstract available.
Results Reference
background
PubMed Identifier
3257429
Citation
Kaplan J, Sarnaik I, Lusher J. Increase in Leu 2+ Leu 7+ lymphocytes in HIV 1-seropositive patients with hemophilia repeatedly treated with clotting factor concentrates. Clin Immunol Immunopathol. 1988 Mar;46(3):337-41. doi: 10.1016/0090-1229(88)90052-9.
Results Reference
background
PubMed Identifier
2903363
Citation
Brown NA, Kovacs A, Lui CR, Hur C, Zaia JA, Mosley JW. Prevalence of antibody to human herpesvirus 6 among blood donors infected with HIV. Lancet. 1988 Nov 12;2(8620):1146. doi: 10.1016/s0140-6736(88)90570-3. No abstract available.
Results Reference
background
PubMed Identifier
3133772
Citation
Aledort LM. Blood products and immune changes: impacts without HIV infection. Semin Hematol. 1988 Apr;25(2 Suppl 1):14-9. No abstract available.
Results Reference
background
PubMed Identifier
3359565
Citation
Bishop PC, Boone D, Parker JW. Immunophenotypes by flow cytometry: a longitudinal study in healthy individuals. Diagn Clin Immunol. 1988;5(5):232-40.
Results Reference
background
PubMed Identifier
3343536
Citation
Gjerset GF, Vyas GN, Bhat R, Operskalski EA. Phenotypes for group-specific component among patients exposed to human immunodeficiency virus by transfusions. J Infect Dis. 1988 Mar;157(3):609-10. doi: 10.1093/infdis/157.3.609. No abstract available.
Results Reference
background
Citation
Govindarajan S, Edwards VM, Stuart ML, Operskalski EA, Mosley JW and the Transfusion Safety Study Group: Influence of Human Immunodeficiency Virus Infection Upon Expression of Chronic Hepatitis B and D Virus Infections. In: Zuckerman AJ (Ed), Viral Hepatitis and Liver Disease, Alan R Liss, Inc, New York, pp 210-214, 1988
Results Reference
background
Citation
McClure E, Gaynor S, Veiga-Benach A, O'Neil D, and the Transfusion Safety Study Group: Notification of Recipients of Human Immunodeficiency Virus (HIV) Antibody Positive Transfusions. Nursing, Jan; 10, 1989
Results Reference
background
PubMed Identifier
2787852
Citation
Norman GL, Barker SS, Rasheed S. Immunoblot reactivity of a non-HIV protein with human sera. Transfusion Safety Study Group. J Clin Lab Anal. 1989;3(3):148-51. doi: 10.1002/jcla.1860030303.
Results Reference
background
Citation
Mosley JW, Nowicki M, Kleinman SH, Dietrich SL and the Transfusion Safety Study Group: Reactivation of Hepatitis B. Lancet, 1:1083-1084, 1989
Results Reference
background
PubMed Identifier
2656018
Citation
Fletcher MA, Azen SP, Adelsberg B, Gjerset G, Hassett J, Kaplan J, Niland JC, Odom-Maryon T, Parker JW, Stites DP, et al. Immunophenotyping in a multicenter study: the Transfusion Safety Study experience. Clin Immunol Immunopathol. 1989 Jul;52(1):38-47. doi: 10.1016/0090-1229(89)90191-8.
Results Reference
background
PubMed Identifier
2672433
Citation
Kleinman SH, Niland JC, Azen SP, Operskalski EA, Barbosa LH, Chernoff AI, Edwards VM, Lenes BA, Marshall GJ, Nemo GJ, et al. Prevalence of antibodies to human immunodeficiency virus type 1 among blood donors prior to screening. The Transfusion Safety Study/NHLBI Donor Repository. Transfusion. 1989 Sep;29(7):572-80. doi: 10.1046/j.1537-2995.1989.29789369672.x.
Results Reference
background
PubMed Identifier
2555471
Citation
Lang DJ, Kovacs AA, Zaia JA, Doelkin G, Niland JC, Aledort L, Azen SP, Fletcher MA, Gauderman J, Gjerset GJ, et al. Seroepidemiologic studies of cytomegalovirus and Epstein-Barr virus infections in relation to human immunodeficiency virus type 1 infection in selected recipient populations. Transfusion Safety Study Group. J Acquir Immune Defic Syndr (1988). 1989;2(6):540-9.
Results Reference
background
PubMed Identifier
2572078
Citation
Operskalski EA, Schiff ER, Kleinman SH, Busch M, Taylor PE, Parks WP, Lee H, Tomasulo PA, Donegan E, Stuart M, et al. Epidemiologic background of blood donors with antibody to human T-cell lymphotropic virus. Transfusion Safety Study Group. Transfusion. 1989 Oct;29(8):746-8. doi: 10.1046/j.1537-2995.1989.29890020448.x.
Results Reference
background
PubMed Identifier
2910017
Citation
Edwards VM, Mosley JW. Reproducibility in quality control of protein (Western) immunoblot assay for antibodies to human immunodeficiency virus. Am J Clin Pathol. 1989 Jan;91(1):75-8. doi: 10.1093/ajcp/91.1.75.
Results Reference
background
PubMed Identifier
2182228
Citation
Parker JW, Adelsberg B, Azen SP, Boone D, Fletcher MA, Gjerset GF, Hassett J, Kaplan J, Niland JC, Odom-Maryon T, et al. Leukocyte immunophenotyping by flow cytometry in a multisite study: standardization, quality control, and normal values in the Transfusion Safety Study. The Transfusion Safety Study Group. Clin Immunol Immunopathol. 1990 May;55(2):187-220. doi: 10.1016/0090-1229(90)90097-a.
Results Reference
background
PubMed Identifier
2393211
Citation
Donegan E, Busch MP, Galleshaw JA, Shaw GM, Mosley JW. Transfusion of blood components from a donor with human T-lymphotropic virus type II (HTLV-II) infection. The Transfusion Safety Study Group. Ann Intern Med. 1990 Oct 1;113(7):555-6. doi: 10.7326/0003-4819-113-7-555. No abstract available.
Results Reference
background
PubMed Identifier
1971398
Citation
Busch MP, Donegan E, Stuart M, Mosley JW. Donor HIV-1 p24 antigenaemia and course of infection in recipients Transfusion Safety Study Group. Lancet. 1990 Jun 2;335(8701):1342. doi: 10.1016/0140-6736(90)91221-u. No abstract available.
Results Reference
background
PubMed Identifier
2120588
Citation
Busch MP, Taylor PE, Lenes BA, Kleinman SH, Stuart M, Stevens CE, Tomasulo PA, Allain JP, Hollingsworth CG, Mosley JW. Screening of selected male blood donors for p24 antigen of human immunodeficiency virus type 1. The Transfusion Safety Study Group. N Engl J Med. 1990 Nov 8;323(19):1308-12. doi: 10.1056/NEJM199011083231904.
Results Reference
background
PubMed Identifier
2124751
Citation
Dietrich SL, Mosley JW, Lusher JM, Hilgartner MW, Operskalski EA, Habel L, Aledort LM, Gjerset GF, Koerper MA, Lewis BH, et al. Transmission of human immunodeficiency virus type 1 by dry-heated clotting factor concentrates. Transfusion Safety Study Group. Vox Sang. 1990;59(3):129-35. doi: 10.1111/j.1423-0410.1990.tb00846.x.
Results Reference
background
PubMed Identifier
2240875
Citation
Donegan E, Stuart M, Niland JC, Sacks HS, Azen SP, Dietrich SL, Faucett C, Fletcher MA, Kleinman SH, Operskalski EA, et al. Infection with human immunodeficiency virus type 1 (HIV-1) among recipients of antibody-positive blood donations. Ann Intern Med. 1990 Nov 15;113(10):733-9. doi: 10.7326/0003-4819-113-10-733.
Results Reference
background
PubMed Identifier
1986462
Citation
Busch MP, Young MJ, Samson SM, Mosley JW, Ward JW, Perkins HA. Risk of human immunodeficiency virus (HIV) transmission by blood transfusions before the implementation of HIV-1 antibody screening. The Transfusion Safety Study Group. Transfusion. 1991 Jan;31(1):4-11. doi: 10.1046/j.1537-2995.1991.31191096183.x.
Results Reference
background
PubMed Identifier
1670589
Citation
Parks WP, Lenes BA, Tomasulo PA, Schiff ER, Parks ES, Shaw GM, Lee H, Yan HQ, Lai S, Hollingsworth CG, et al. Human T-cell lymphotropic virus infection among blood donors in south Florida. The Transfusion Safety Study Group. J Acquir Immune Defic Syndr (1988). 1991;4(1):89-96.
Results Reference
background
PubMed Identifier
1346752
Citation
Aledort LM, Hilgartner MW, Pike MC, Gjerset GF, Koerper MA, Lian EY, Lusher JM, Mosley JW. Variability in serial CD4 counts and relation to progression of HIV-I infection to AIDS in haemophilic patients. Transfusion Safety Study Group. BMJ. 1992 Jan 25;304(6821):212-6. doi: 10.1136/bmj.304.6821.212.
Results Reference
background
PubMed Identifier
1512686
Citation
Busch MP, Henrard DR, Hewlett IK, Mehaffey WF, Epstein JS, Allain JP, Lee TH, Mosley JW. Poor sensitivity, specificity, and reproducibility of detection of HIV-1 DNA in serum by polymerase chain reaction. The Transfusion Safety Study Group. J Acquir Immune Defic Syndr (1988). 1992;5(9):872-7.
Results Reference
background
PubMed Identifier
1638032
Citation
Fletcher MA, Mosley JW, Hassett J, Gjerset GF, Kaplan J, Parker JW, Donegan E, Lusher JM, Lee H. Effect of age on human immunodeficiency virus type 1-induced changes in lymphocyte populations among persons with congenital clotting disorders. Transfusion Safety Study Group. Blood. 1992 Aug 1;80(3):831-40.
Results Reference
background
PubMed Identifier
1731439
Citation
Donegan E, Pell P, Lee H, Shaw GM, Mosley JW. Transmission of human T-lymphotropic virus type I by blood components from a donor lacking anti-p24: a case report. The Transfusion Safety Study Group. Transfusion. 1992 Jan;32(1):68-71. doi: 10.1046/j.1537-2995.1992.32192116436.x.
Results Reference
background
PubMed Identifier
1673714
Citation
Fletcher MA, Gjerset GF, Hassett J, Donegan E, Parker JW, Mosley JW. Lymphocyte immunophenotypes among anti-HTLV-I/II-positive blood donors and recipients. The Transfusion Safety Study Group. J Acquir Immune Defic Syndr (1988). 1991;4(6):628-32.
Results Reference
background
PubMed Identifier
1768396
Citation
Buckley JD, Pike MC, Mosley JW. Statistical approaches to evaluating prognostic indices in HIV infection. The Transfusion Safety Study Group. AIDS. 1991 Nov;5(11):1398. doi: 10.1097/00002030-199111000-00027. No abstract available.
Results Reference
background
PubMed Identifier
2028130
Citation
Odom-Maryon T, Langholz B, Niland J, Azen S. Generalization of normal discriminant analysis using Fourier series density estimators. Transfusion Safety Study Group. Stat Med. 1991 Mar;10(3):473-85. doi: 10.1002/sim.4780100319.
Results Reference
background
PubMed Identifier
2085537
Citation
Miller K, Donegan E, Curran P, Shelley TJ. Effects of counselling on knowledge about HIV-1 among transfusion recipients and their partners. Transfusion Safety Study Group. AIDS Care. 1990;2(2):155-62. doi: 10.1080/09540129008257726.
Results Reference
background
PubMed Identifier
7658055
Citation
Operskalski EA, Stram DO, Lee H, Zhou Y, Donegan E, Busch MP, Stevens CE, Schiff ER, Dietrich SL, Mosley JW. Human immunodeficiency virus type 1 infection: relationship of risk group and age to rate of progression to AIDS. Transfusion Safety Study Group. J Infect Dis. 1995 Sep;172(3):648-55. doi: 10.1093/infdis/172.3.648.
Results Reference
background
PubMed Identifier
7745674
Citation
Diaz RS, Sabino EC, Mayer A, Mosley JW, Busch MP. Dual human immunodeficiency virus type 1 infection and recombination in a dually exposed transfusion recipient. The Transfusion Safety Study Group. J Virol. 1995 Jun;69(6):3273-81. doi: 10.1128/JVI.69.6.3273-3281.1995.
Results Reference
background
PubMed Identifier
7718880
Citation
Wong WY, Powars DR, Operskalski EA, Hassett J, Parker JW, Sarnaik S, Pegelow CH, Hilgartner MW, Johnson CS, Zhou Y, et al. Blood transfusions and immunophenotypic alterations of lymphocyte subsets in sickle cell anemia. The Transfusion Safety Study Group. Blood. 1995 Apr 15;85(8):2091-7.
Results Reference
background
PubMed Identifier
7940656
Citation
Busch MP, Operskalski EA, Mosley JW, Stevens CE, Schiff ER, Kleinman SH, Lee H, Lee M, Harris M. Epidemiologic background and long-term course of disease in human immunodeficiency virus type 1-infected blood donors identified before routine laboratory screening. Transfusion Safety Study Group. Transfusion. 1994 Oct;34(10):858-64. doi: 10.1046/j.1537-2995.1994.341095026970.x.
Results Reference
background
PubMed Identifier
7910043
Citation
Hilgartner M. Results of the transfusion safety study. Ann Hematol. 1994;68 Suppl 3:S59. doi: 10.1007/BF01774536. No abstract available.
Results Reference
background
PubMed Identifier
7903481
Citation
Hilgartner MW. Changes in CD4 count relative to product usage: findings from the transfusion safety study. Semin Hematol. 1993 Oct;30(4 Suppl 5):7-9. No abstract available.
Results Reference
background
PubMed Identifier
8098792
Citation
Hilgartner MW, Buckley JD, Operskalski EA, Pike MC, Mosley JW. Purity of factor VIII concentrates and serial CD4 counts. The Transfusion Safety Study Group. Lancet. 1993 May 29;341(8857):1373-4. doi: 10.1016/0140-6736(93)90943-b.
Results Reference
background
PubMed Identifier
8096065
Citation
Mosley JW. Low CD4+ counts in a study of transfusion safety: correction. N Engl J Med. 1993 Apr 15;328(15):1128. doi: 10.1056/NEJM199304153281515. No abstract available.
Results Reference
background
PubMed Identifier
8093638
Citation
Aledort LM, Operskalski EA, Dietrich SL, Koerper MA, Gjerset GF, Lusher JM, Lian EC, Mosley JW. Low CD4+ counts in a study of transfusion safety. The Transfusion Safety Study Group. N Engl J Med. 1993 Feb 11;328(6):441-2. doi: 10.1056/NEJM199302113280614. No abstract available. Erratum In: N Engl J Med 1993 Apr 15;328(15):1128.
Results Reference
background
PubMed Identifier
8091731
Citation
Mosley JW, Nowicki MJ, Kasper CK, Donegan E, Aledort LM, Hilgartner MW, Operskalski EA. Hepatitis A virus transmission by blood products in the United States. Transfusion Safety Study Group. Vox Sang. 1994;67 Suppl 1:24-8.
Results Reference
background
PubMed Identifier
8353293
Citation
Hassett J, Gjerset GF, Mosley JW, Fletcher MA, Donegan E, Parker JW, Counts RB, Aledort LM, Lee H, Pike MC. Effect on lymphocyte subsets of clotting factor therapy in human immunodeficiency virus-1-negative congenital clotting disorders. The Transfusion Safety Study Group. Blood. 1993 Aug 15;82(4):1351-7.
Results Reference
background
PubMed Identifier
8516793
Citation
Adams M, Lee TH, Busch MP, Heitman J, Marshall GJ, Gjerset GF, Mosley JW. Rapid freezing of whole blood or buffy coat samples for polymerase chain reaction and cell culture analysis: application to detection of human immunodeficiency virus in blood donor and recipient repositories. The Transfusion Safety Study Group. Transfusion. 1993 Jun;33(6):504-8. doi: 10.1046/j.1537-2995.1993.33693296814.x.
Results Reference
background
PubMed Identifier
9241114
Citation
Operskalski EA, Busch MP, Mosley JW, Stram DO. Comparative rates of disease progression among persons infected with the same or different HIV-1 strains. The Transfusion Safety Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jun 1;15(2):145-50. doi: 10.1097/00042560-199706010-00008.
Results Reference
background
PubMed Identifier
9257660
Citation
Operskalski EA, Mosley JW, Busch MP, Stram DO. Influences of age, viral load, and CD4+ count on the rate of progression of HIV-1 infection to AIDS. Transfusion Safety Study Group. J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jul 1;15(3):243-4. doi: 10.1097/00042560-199707010-00009. No abstract available.
Results Reference
background
PubMed Identifier
8756079
Citation
Wong WY, Zhou Y, Operskalski EA, Hassett J, Powars DR, Mosley JW. Hematologic profile and lymphocyte subpopulations in hemoglobin SC disease: comparison with hemoglobin SS and black controls. The Transfusion Safety Study Group. Am J Hematol. 1996 Jul;52(3):150-4. doi: 10.1002/1096-8652(199607)52:33.0.co;2-6.
Results Reference
background
PubMed Identifier
8656010
Citation
Busch MP, Operskalski EA, Mosley JW, Lee TH, Henrard D, Herman S, Sachs DH, Harris M, Huang W, Stram DO. Factors influencing human immunodeficiency virus type 1 transmission by blood transfusion. Transfusion Safety Study Group. J Infect Dis. 1996 Jul;174(1):26-33. doi: 10.1093/infdis/174.1.26.
Results Reference
background
PubMed Identifier
8705863
Citation
Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D. The seroepidemiology of human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus): distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med. 1996 Aug;2(8):918-24. doi: 10.1038/nm0896-918. Erratum In: Nat Med 1996 Sep;2(9):1041.
Results Reference
background
PubMed Identifier
7915149
Citation
Gjerset GF, Pike MC, Mosley JW, Hassett J, Fletcher MA, Donegan E, Parker JW, Counts RB, Zhou Y, Kasper CK, et al. Effect of low- and intermediate-purity clotting factor therapy on progression of human immunodeficiency virus infection in congenital clotting disorders. Transfusion Safety Study Group. Blood. 1994 Sep 1;84(5):1666-71.
Results Reference
background
PubMed Identifier
9084787
Citation
Diaz RS, Zhang L, Busch MP, Mosley JW, Mayer A. Divergence of HIV-1 quasispecies in an epidemiologic cluster. AIDS. 1997 Mar 15;11(4):415-22. doi: 10.1097/00002030-199704000-00003.
Results Reference
background
PubMed Identifier
9032400
Citation
Zhang L, Diaz RS, Ho DD, Mosley JW, Busch MP, Mayer A. Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo. J Virol. 1997 Mar;71(3):2555-61. doi: 10.1128/JVI.71.3.2555-2561.1997.
Results Reference
background
PubMed Identifier
8870851
Citation
Diaz RS, Sabino EC, Mayer A, deOliveira CF, Mosley JW, Busch MP. Lack of dual HIV infection in a transfusion recipient exposed to two seropositive blood components. AIDS Res Hum Retroviruses. 1996 Sep 1;12(13):1291-5. doi: 10.1089/aid.1996.12.1291. No abstract available.
Results Reference
background
PubMed Identifier
7831863
Citation
Mosley JW. Has hepatitis A virus been transmitted by clotting factor concentrates among hemophiliacs in the United States? Vox Sang. 1994;67 Suppl 4:12-5; discussion 24-6.
Results Reference
background
PubMed Identifier
9345119
Citation
Operskalski EA, Stram DO, Busch MP, Huang W, Harris M, Dietrich SL, Schiff ER, Donegan E, Mosley JW. Role of viral load in heterosexual transmission of human immunodeficiency virus type 1 by blood transfusion recipients. Transfusion Safety Study Group. Am J Epidemiol. 1997 Oct 15;146(8):655-61. doi: 10.1093/oxfordjournals.aje.a009331.
Results Reference
background
PubMed Identifier
1109967
Citation
Vasil'eva VF, Vorob'eva KP. [Study of magnesium transport in the dog kidney by the method of stopping urine emission in chronic experiments]. Fiziol Zh SSSR Im I M Sechenova. 1975 Jan;61(1):130-5. No abstract available. Russian.
Results Reference
background
PubMed Identifier
9806051
Citation
Wilkinson DA, Operskalski EA, Busch MP, Mosley JW, Koup RA. A 32-bp deletion within the CCR5 locus protects against transmission of parenterally acquired human immunodeficiency virus but does not affect progression to AIDS-defining illness. J Infect Dis. 1998 Oct;178(4):1163-6. doi: 10.1086/515675.
Results Reference
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Available IPD and Supporting Information:
Available IPD/Information Type
Study Protocol
Available IPD/Information URL
http://biolincc.nhlbi.nih.gov/studies/tss/
Available IPD/Information Identifier
TSS
Available IPD/Information Comments
Samples and characterization data. NHLBI provides controlled access to samples through BioLINCC. Access requires registration, evidence of local IRB approval or certification of exemption from IRB review, and completion of a materials use agreement.
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Transfusion Safety Study (TSS)
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