Combination Chemotherapy in Treating Women With Stage II or Stage III Breast Cancer
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage II breast cancer, stage IIIA breast cancer, stage IIIB breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage IIA, IIB, or III breast cancer treated with radical surgery (e.g., mastectomy, quadrantectomy, tumorectomy) and axillary lymph node dissection Positive axillary lymph nodes No more than 9 metastatic lymph nodes No distant metastases or local or locoregional disease No more than 5 weeks between surgery and beginning of study Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 70 and under Sex: Female Menopausal status: Not specified Performance status: ECOG 0 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Absolute neutrophil count at least 2,000/mm3 Platelet count at least 100,000/mm3 Hepatic: Transaminases, alkaline phosphatase, and gamma glutamyltransferase no greater than 1.5 times upper limit of normal Renal: Not specified Cardiovascular: No heart disease that precludes use of anthracyclines (i.e., myocardial infarction, uncontrolled angina pectoris, uncontrolled arrhythmias, or valve disease) Other: No concurrent pathology that precludes use of antineoplastic drugs No mental retardation or psychiatric disease that precludes study No other current or prior malignancy within the past 10 years except squamous or basal cell skin cancer or carcinoma in situ of the cervix Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: No prior antineoplastic hormonal therapy Radiotherapy: No postoperative radiotherapy except to residual breast Surgery: See Disease Characteristics
Sites / Locations
- Ospedale San Lazzaro
- Ospedale Civile di Asti
- Ospedale Oncologico A. Businco
- Santo Spirito Hospital
- Ospedale Santa Croce
- Ospedale Galliera Oncologia
- Istituto Nazionale per la Ricerca sul Cancro
- Ospendale S. Andrea EST
- Ospedale Civile di Livorno
- Carlo Poma Hospital
- Azienda USSL NO 8
- Instituto Scientifico H.S. Raffaele
- Ospedale Santa Croce
- I.R.C.C.S. Policlinico San Matteo
- Ospedale St. Santa Chiara
- USL NO 1
- Azienda U.S.L. 1 - Sassari
- Ospedale S. Paolo
- Osp. Civile USL 18
- Ospedale Sant Anna
- Ospedale Evangelico Valdese
- OIRM - Sant Anna
- Ospedale Mauriziano Umberto I
- Ospedale Maggiore dell' Universita
- Ospedale Molinette