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Aplastic Anemia Epidemiology: Incidence and Case-control

Primary Purpose

Blood Disease, Anemia, Aplastic

Status
Completed
Phase
Locations
Study Type
Observational
Intervention
Sponsored by
National Heart, Lung, and Blood Institute (NHLBI)
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Blood Disease

Eligibility Criteria

undefined - 100 Years (Child, Adult, Older Adult)MaleDoes not accept healthy volunteers

No eligibility criteria

Sites / Locations

    Outcomes

    Primary Outcome Measures

    Secondary Outcome Measures

    Full Information

    First Posted
    May 25, 2000
    Last Updated
    February 17, 2016
    Sponsor
    National Heart, Lung, and Blood Institute (NHLBI)
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    1. Study Identification

    Unique Protocol Identification Number
    NCT00005682
    Brief Title
    Aplastic Anemia Epidemiology: Incidence and Case-control
    Study Type
    Observational

    2. Study Status

    Record Verification Date
    May 2000
    Overall Recruitment Status
    Completed
    Study Start Date
    September 1988 (undefined)
    Primary Completion Date
    undefined (undefined)
    Study Completion Date
    August 1994 (Actual)

    3. Sponsor/Collaborators

    Name of the Sponsor
    National Heart, Lung, and Blood Institute (NHLBI)

    4. Oversight

    5. Study Description

    Brief Summary
    To conduct incidence and case-control studies of aplastic anemia in metropolitan Bangkok, Thailand
    Detailed Description
    BACKGROUND: Aplastic anemia, a form of bone marrow failure, is a disease of largely unknown cause, except for the rare situations involving high doses of radiation. Many agents have been mentioned in case reports to be associated with the development of aplastic anemia and include drugs, chemicals, pesticides, radiation, and viral infection. Of these, chloramphenicol, phenylbutazone, and insecticides are most frequently reported. In the United States and other developed countries the disease prevalence is so low that too few cases occur to make an epidemiological study in a single city logistically feasible. The Bangkok hospitalization rate for aplastic anemia was sufficient to conduct a case-control study. Also, a study conducted in this locale provided information on drugs and chemicals not commonly used in developed countries. DESIGN NARRATIVE: All aplastic anemia cases in metropolitan Bangkok were located and verified in the forty hospitals that agreed to participate in the study. Incidence rates were calculated by age group and sex. In the case-control study, interviews were used to obtain comprehensive histories of drug, chemical, pesticide, radiation, viral infections, and other exposures, along with relevant demographic and medical history information in order to examine the association between and test hypotheses regarding suspected hazards and to estimate the risks of developing aplastic anemia. The basic epidemiologic features of aplastic anemia were described by characterizing these patients in terms of standard demographic variables, age, race, sex, and medical history. The degree of association between viral hepatitis and the development of aplastic anemia was estimated. The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Blood Disease, Anemia, Aplastic

    7. Study Design

    10. Eligibility

    Sex
    Male
    Maximum Age & Unit of Time
    100 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    No eligibility criteria
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Paul Leaverton
    First Name & Middle Initial & Last Name & Degree
    Samuel Shapiro

    12. IPD Sharing Statement

    Citations:
    PubMed Identifier
    7577657
    Citation
    Issaragrisil S, Kaufman DW, Anderson TE, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakham Y, Vannasaeng S, Leaverton PE, et al. An association of aplastic anaemia in Thailand with low socioeconomic status. Aplastic Anemia Study Group. Br J Haematol. 1995 Sep;91(1):80-4. doi: 10.1111/j.1365-2141.1995.tb05248.x.
    Results Reference
    background
    PubMed Identifier
    1318006
    Citation
    Hibbs JR, Issaragrisil S, Young NS. High prevalence of hepatitis C viremia among aplastic anemia patients and controls from Thailand. Am J Trop Med Hyg. 1992 May;46(5):564-70. doi: 10.4269/ajtmh.1992.46.564.
    Results Reference
    background
    PubMed Identifier
    2029577
    Citation
    Issaragrisil S, Sriratanasatavorn C, Piankijagum A, Vannasaeng S, Porapakkham Y, Leaverton PE, Kaufman DW, Anderson TE, Shapiro S, Young NS. Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group. Blood. 1991 May 15;77(10):2166-8.
    Results Reference
    background
    PubMed Identifier
    9222791
    Citation
    Kaufman DW, Issaragrisil S, Anderson T, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakkham Y, Vannasaeng S, Leaverton PE, Shapiro S, Young NS. Use of household pesticides and the risk of aplastic anaemia in Thailand. The Aplastic Anemia Study Group. Int J Epidemiol. 1997 Jun;26(3):643-50. doi: 10.1093/ije/26.3.643.
    Results Reference
    background
    PubMed Identifier
    9166842
    Citation
    Issaragrisil S, Kaufman DW, Anderson T, Chansung K, Thamprasit T, Sirijirachai J, Piankijagum A, Porapakkham Y, Vannasaeng S, Leaverton PE, Shapiro S, Young NS. Low drug attributability of aplastic anemia in Thailand. The Aplastic Anemia Study Group. Blood. 1997 Jun 1;89(11):4034-9.
    Results Reference
    background
    PubMed Identifier
    9141447
    Citation
    Issaragrisil S, Kaufman D, Thongput A, Chansung K, Thamprasit T, Piankijagum A, Anderson T, Shapiro S, Leaverton P, Young NS. Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand. Hepatology. 1997 May;25(5):1255-7. doi: 10.1002/hep.510250532.
    Results Reference
    background
    PubMed Identifier
    8987238
    Citation
    Issaragrisil S, Kaufman DW, Anderson T. Incidence and non-drug aetiologies of aplastic anaemia in Thailand. The Thai Aplastic Anaemia Study Group. Eur J Haematol Suppl. 1996;60:31-4. doi: 10.1111/j.1600-0609.1996.tb01642.x.
    Results Reference
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    Aplastic Anemia Epidemiology: Incidence and Case-control

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