A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients

Inclusion Criteria Patients may be eligible for this study if they: Are HIV-positive. Are at least 18 years old. Agree not to have intercourse 2 weeks before, during, and 2 weeks after study or agree to use effective methods of birth control. Have had HIV-1 RNA levels less than 400 copies/ml on the 2 most recent measurements. Have at least 1 of the following situations: (a) at least 1 of the following: (1) decrease in facial fat, (2) decrease in fat in lower limbs, or (3) decrease in fat in buttocks area; or (b) an increase in lactate level greater than 2.2 mmol/L at the screening visit plus at least 1 of the following: (1) decrease in facial fat, (2) decrease in fat in lower limbs, or (3) decrease in fat in the buttocks area; or (c) an increase in lactate level greater than 2.2 mmol/L at screening visit plus at least 2 of the following: (1) shortness of breath, (2) weakness, (3) fast heartbeat, (4) recent weight loss (10 lbs. within the past 2 months), (5) pain and/or bloating in the abdomen, (6) nausea and/or vomiting and/or lack of appetite; or (d) lactate level greater than 3.2 mmol/L at the screening visit. Are able to read at a sixth-grade level. Have taken d4T consistently for the 6 months before entering study. Exclusion Criteria Patients will not be eligible for this study if they: Have diabetes or kidney failure. Have any condition that makes them unable to participate in this study. Are unable to take medications by mouth. Have serious medical conditions, such as congestive heart failure or other heart disease, which would affect the safety of the patient. Are taking or have taken abacavir plus Retrovir or Combivir. Are pregnant or breast-feeding. Are enrolled in other clinical studies. Have had a reaction to or are unable to take abacavir and have taken Retrovir in the past. Have taken hydroxyurea within the past 3 days or plan to take this drug during the study. Have had chemotherapy or radiation therapy within 4 weeks prior to screening visit (except for local treatment for Kaposi's sarcoma) or plan to have such treatment during the study. Have taken drugs that affect the immune system, such as systemic corticosteroids, interleukins, vaccines, or interferons, within 4 weeks prior to the screening visit. Have had an HIV vaccine within 3 months of the screening visit. Have taken recombinant Human Growth Hormone (r-hGH), megestrol acetate, medicines containing oxandrolone, oxymetholone, nandrolone, DHEA, or other testosterone derivatives, or glucocorticoids or other systemic steroids (except inhaled and topical steroids) in the last 4 months or plan to take these drugs during the study.