Oxaliplatin With Or Without Floxuridine and Leucovorin in Treating Patients With Metastatic Cancer of the Peritoneum
Cancer
About this trial
This is an interventional treatment trial for Cancer focused on measuring stage IV colon cancer, stage IV gastric cancer, recurrent gastric cancer, recurrent pancreatic cancer, recurrent colon cancer, regional neuroblastoma, stage 4S neuroblastoma, recurrent neuroblastoma, regional gastrointestinal carcinoid tumor, metastatic gastrointestinal carcinoid tumor, recurrent gastrointestinal carcinoid tumor, advanced adult primary liver cancer, recurrent adult primary liver cancer, gastrinoma, small intestine adenocarcinoma, small intestine lymphoma, small intestine leiomyosarcoma, unresectable gallbladder cancer, recurrent gallbladder cancer, unresectable extrahepatic bile duct cancer, recurrent extrahepatic bile duct cancer, recurrent small intestine cancer, insulinoma, recurrent islet cell carcinoma, WDHA syndrome, somatostatinoma, pancreatic polypeptide tumor, glucagonoma, regional pheochromocytoma, metastatic pheochromocytoma, recurrent pheochromocytoma, extragonadal germ cell tumor, liver metastases, malignant ascites, newly diagnosed carcinoma of unknown primary, carcinoma of the appendix, pseudomyxoma peritonei, fallopian tube cancer, primary peritoneal cavity cancer, recurrent carcinoma of unknown primary, gastrointestinal stromal tumor, stage IV pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed metastatic or unresectable cancer largely confined to the peritoneal cavity Fully resected and/or electrocauterized metastatic disease involving the peritoneum (stage IV, no residual disease) allowed No known brain metastases PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm^3 Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin normal SGOT/SGPT no greater than 2.5 times upper limit of normal Renal: Creatinine normal OR Creatinine clearance at least 60 mL/min Cardiovascular: No symptomatic congestive heart failure No unstable angina pectoris No cardiac arrhythmia Other: No history of allergy to platinum compounds or antiemetics that would preclude study No other uncontrolled illness (e.g., active infection) No evidence of neuropathy Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: At least 4 weeks since prior cytotoxic chemotherapy (6 weeks for mitomycin or nitrosoureas) and recovered Endocrine therapy: Not specified Radiotherapy: At least 4 weeks since prior radiotherapy and recovered Surgery: See Disease Characteristics Other: No other concurrent investigational agents No concurrent antiretroviral therapy (HAART)
Sites / Locations
- Memorial Sloan-Kettering Cancer Center