Filgrastim Compared With Sargramostim Plus Chemotherapy, Peripheral Stem Cell Transplantation, and Interferon Alfa in Treating Patients With Multiple Myeloma
Multiple Myeloma and Plasma Cell Neoplasm
About this trial
This is an interventional treatment trial for Multiple Myeloma and Plasma Cell Neoplasm focused on measuring stage I multiple myeloma, stage II multiple myeloma, stage III multiple myeloma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed multiple myeloma Complete or partial remission after initial therapy OR Complete or partial response to therapy after disease progression following initial therapy No plasma cell leukemia (greater than 10% circulating plasma cells) No advanced myeloma refractory and unresponsive to at least 2 salvage chemotherapy regimens PATIENT CHARACTERISTICS: Age: 70 and under Performance status: Age 65-70 years: Karnofsky 80-100% Under 65 years: Not specified Life expectancy: Not specified Hematopoietic: Hemoglobin at least 8 g/dL (untransfused) WBC at least 3,000/mm^3 Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 (untransfused) Hepatic: Bilirubin less than 2.0 mg/dL ALT less than 3 times upper limit of normal Renal: Age 65-70 years: Creatinine clearance greater than 60 mL/min (if creatinine at least 1.5 mg/dL) Under 65 years: Creatinine less than 2 mg/dL Cardiovascular: Age 65-70 years: LVEF at least 45% Under 65 years: No active ischemia LVEF greater than 45% by MUGA Pulmonary: Age 65-70 years: If history of smoking or respiratory symptoms, spirometry and DLCO must be greater than 50% of predicted Under 65 years: FEV_1 and FVC greater than 60% predicted DLCO greater than 50% of predicted Other: No active or uncontrolled infection PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics Surgery: Not specified
Sites / Locations
- University of Minnesota Cancer Center