Etanercept (Enbrel) to Treat Pain and Swelling After Third Molar Extraction
Healthy, Inflammation

About this trial
This is an interventional treatment trial for Healthy focused on measuring Oral Surgery, Swelling, Pain, TNF, Etanercept
Eligibility Criteria
INCLUSION CRITERIA Male or female volunteers referred for extraction of third molars willing to undergo two surgical appointments for the extraction of unilateral third molars. Between the ages of 16 to 35 years (based upon eruption patterns and age-related complications associated with surgical extraction of third molars). In good general health - ASA status 1 or 2 (healthy subjects based upon criteria for safe outpatient conscious sedation). Willing to undergo observation period for four hours postoperatively. Willing to return at 48 hours for measurement of pain, swelling, and tissue biopsy. Willing to return for a total of four visits beyond the screening visit. EXCLUSION CRITERIA Pregnant or lactating females. Current mental disorder or substance abuse. Allergy to aspirin or NSAIDs. Chronic use of medications confounding assessment of the inflammatory response or analgesia (antihistamines, NSAIDs, steroids, antidepressants). Presence of chronic debilitating disease (such as diabetes, rheumatoid arthritis, liver disease, etc). Presence of symptomatic tooth suggesting infection or inflammation. Unusual surgical difficulty encountered during the surgical procedure.
Sites / Locations
- National Institute of Dental And Craniofacial Research (NIDCR)