Magnetic Resonance Imaging for Evaluating Kidney Function

INCLUSION CRITERIA Healthy volunteers or patients with significant clinical suspicion of renovascular hypertension. Subjects able to understand the informed consent for this study. Subjects must be able to hold their breath for 20 second intervals. Patients must be clinically stable and be judged by their physician able to tolerate the MR study of 1.5-2 hour duration. EXCLUSION CRITERIA Any contraindication for MR study including: pacemaker or other implanted electronic device; cochlear implants; metal in the eye; embedded shrapnel fragments; cerebral aneurysm clips; or medical infusion pumps. Allergy to gadolinium, iodinated contrast media, ACEIs, or sulphur-containing medication. Patients have a hematocrit at or below 30. Severe anemia may predispose to hypotension after captopril. Patients with hyperkalemia (plasma potassium: above 5.0 mmol/L), because of the risk of arrhythmia. Clinically unstable patients and those unable to tolerate a 1-2 hour MR study. Examples of medical conditions that would lead to exclusion include unstable angina, dyspnea at rest, severe pain at rest, or severe back pain. Pregnancy. Nursing mothers. Subjects who are claustrophobic and are unable to tolerate MR imaging. Patients with a serum creatinine concentration above 4mg/dl. Bilateral renal stents. Healthy subjects must not have an abnormality detected on dipstick urinalysis, or a systolic BP above 140 mmHg or a diastolic BP above 90 mmHg on screening examination or an abnormal BUN or creatinine level in the blood.