Study of Cushing's Syndrome Not Related to ACTH Production
Cushing's Syndrome, Healthy
About this trial
This is an observational trial for Cushing's Syndrome focused on measuring Cushing's Syndrome, Adrenal Glands, Proteomics, Cortisol
Eligibility Criteria
PATIENTS WITH NORMAL ADRENAL GLANDS: Patients with normal adrenal glands will be recruited from those studied under NCI protocols. They will not have taken suppressive doses of glucocorticoids for 12 months, and will not have any known adrenal pathology, either of the cortex or medulla. They will not have Von-Hippel Lindau syndrome. PATIENTS WITH ACTH-INDEPENDENT CUSHING'S SYNDROME: Will be aged 18 or older; Will have plasma ACTH levels of 10 pg/mL or less; Will have an outside physician who will follow them after surgery. Must not weigh greater than 380 pounds. These patients are unable to undergo CT scans. Must not have a CT scan showing normal or atrophic bilateral adrenal glands. Must not have a CRH test showing a response as defined above. The diagnosis of these patients will need further evaluation. Must not have any condition that would preclude surgery, including advanced heart failure, significant coronary artery disease, severe pulmonary disease. Must not have a hematocrit less than 30 or research blood withdraw greater than 450 mL in the previous six weeks. Must not be pregnant. Must not have a history of angina or known coronary artery disease, because these patients are at risk for exacerbation during the vasopressin test. The SF-36 questionnaire will only be given to individuals who speak and read English fluently. Patients may participate in the remainder of the study, however, if they do not meet this criterion.
Sites / Locations
- National Institute of Child Health and Human Development (NICHD)