Role of Prostaglandins in the Regulation of Brain Blood Flow
Healthy, Hypercapnia
About this trial
This is an observational trial for Healthy focused on measuring Cerebral Blood Flow, CO2 Inhalation, Imaging, MRI, Perfusion, Functional Activation
Eligibility Criteria
INCLUSION CRITERIA: Any healthy normal volunteer above the age of 18 who is capable of giving informed consent. EXCLUSION CRITERIA: Subjects will be excluded for the following reasons. They have contraindications to MR scanning, such as the following: aneurysm clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, cochlear implant, ocular foreign body (e.g., metal shavings), or insulin pump. They have panic disorder or migraine (because of possible complications with CO2 inhalation). They have cirrhosis, any renal dysfunction, or a chronic respiratory illness (such as asthma). They have allergies to sulfonamide drugs or cyclo-oxygenase inhibitors (NSAIDS).
Sites / Locations
- Warren G. Magnuson Clinical Center (CC)