Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum
Colorectal Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring stage II rectal cancer, stage III rectal cancer, adenocarcinoma of the rectum
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed adenocarcinoma of the distal rectum Located 0-9 cm from the dentate line (3-12 cm from the anal verge) No extension of malignant disease into the anal canal Lesions may be mobile stage T3 by endorectal ultrasound OR fixed, defined as clinical stage T4, by palpation No evidence of distant metastases PATIENT CHARACTERISTICS: Age: Over 18 Performance status: Zubrod 0-1 Life expectancy: Not specified Hematopoietic: WBC (white blood cell count) greater than 4,000/mm^3 Platelet count greater than 130,000/mm^3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal Alkaline phosphatase, SGOT (serum glutamic oxaloacetic transaminase), and LDH (lactate dehydrogenase) normal Renal: Creatinine normal Other: Not pregnant or nursing Fertile patients must use effective contraception No other invasive malignancy within the past 5 years except: Inactive nonmelanomatous skin cancer Carcinoma in situ of the cervix Synchronous colonic cancer if tumor is Tis or T1 and has been completely resected No other serious medical illnesses PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to pelvis Surgery: Not specified Other: No concurrent antiepileptic drugs
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- Comprehensive Cancer Institute of Huntsville
- Huntsville Hospital System
- MBCCOP - Gulf Coast
- Alabama Oncology, LLC
- Radiation Oncology Associates of West Alabama
- Foundation for Cancer Research and Education
- Mount Diablo Medical Center
- City of Hope Comprehensive Cancer Center
- Saint Agnes Cancer Center
- California Cancer Center
- Sutter Health West Cancer Research Group
- Loma Linda University Medical Center
- Veterans Affairs Medical Center - Long Beach
- Jonsson Comprehensive Cancer Center, UCLA
- USC/Norris Comprehensive Cancer Center and Hospital
- CCOP - Bay Area Tumor Institute
- Huntington Cancer Center
- Cancer Care Center
- Radiation Oncology Center - Sacramento
- Radiation Medical Group, Inc.
- UCSF Cancer Center and Cancer Research Institute
- O'Connor Hospital
- CCOP - Santa Rosa Memorial Hospital
- David Grant Medical Center
- Memorial Hospital Cancer Center
- University of Colorado Cancer Center
- Saint Mary's Hospital and Medical Center
- Hospital of St. Raphael
- CCOP - Christiana Care Health Services
- University of Florida Health Science Center
- Florida Radiation Oncology Group
- Health First Holmes Regional Medical Center
- CCOP - Mount Sinai Medical Center
- Veterans Affairs Medical Center - Miami
- Sylvester Cancer Center, University of Miami
- Baptist Hospital of Miami
- MD Anderson Cancer Center Orlando
- Bay Medical Center
- Gulf Coast Cancer Treatment Center
- Sarasota Radiation and Medical Oncology Center
- Tallahassee Memorial Healthcare
- H. Lee Moffitt Cancer Center and Research Institute
- Emory University Hospital - Atlanta
- CCOP - Atlanta Regional
- Medical Center/John B. Amos Community Cancer Center
- Regional Radiation Oncology Center at Rome
- MBCCOP - Hawaii
- Northwest Community Hospital
- Northwestern Memorial Hospital
- CCOP - Central Illinois
- Ingalls Memorial Hospital
- Loyola University Medical Center
- Lutheran General Cancer Care Center
- Methodist Medical Center of Illinois
- St. John's Medical Center
- Bloomington Hospital
- Veterans Affairs Medical Center - Indianapolis (Roudebush)
- Clarian Health Partners Inc.
- Regional Cancer Center
- Ball Memorial Hospital
- CCOP - Northern Indiana CR Consortium
- Wendt Regional Cancer Center of Finley Hospital
- Central Baptist Hospital
- Albert B. Chandler Medical Center, University of Kentucky
- James Graham Brown Cancer Center
- Louisville Radiation Oncology
- Merle M. Mahr Cancer Center
- Mary Bird Perkins Cancer Center
- Tulane University School of Medicine
- MBCCOP - LSU Health Sciences Center
- CCOP - Ochsner
- Maine Medical Center
- Anne Arundel Oncology Center
- Marlene and Stewart Greenebaum Cancer Center, University of Maryland
- Greater Baltimore Medical Center and Cancer Center
- Harbor Hospital Center
- Sinai Hospital of Baltimore
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Peninsula Regional Medical Center
- Dana-Farber Cancer Institute
- Cape Cod Hospital
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
- CCOP - Ann Arbor Regional
- University of Michigan Comprehensive Cancer Center
- Barbara Ann Karmanos Cancer Institute
- Henry Ford Hospital
- Hurley Medical Center
- McLaren Regional Cancer Center
- CCOP - Kalamazoo
- Marquette General Hospital
- MidMichigan Medical Center - Midland
- CCOP - Beaumont
- William Beaumont Hospital
- William Beaumont Hospital - Troy
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Ellis Fischel Cancer Center - Columbia
- CCOP - Kansas City
- Mallinckrodt Institute of Radiology
- St. Louis University Health Sciences Center
- Cancer Research for the Ozarks
- CCOP - Cancer Research for the Ozarks
- CCOP - Montana Cancer Consortium
- CCOP - Missouri Valley Cancer Consortium
- Methodist Cancer Center - Omaha
- Nebraska Health System
- CCOP - Southern Nevada Cancer Research Foundation
- Norris Cotton Cancer Center
- Elliot Regional Cancer Center
- Veterans Affairs Medical Center - East Orange
- John F. Kennedy Medical Center
- Trinitas Hospital - Jersey Street Campus
- Monmouth Medical Center
- South Jersey Regional Cancer Center
- Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County
- Cancer Institute of New Jersey
- Newark Beth Israel Medical Center
- Atlantic City Medical Center
- Valley Hospital
- Community Medical Center
- St. Francis Medical Center
- Associated Radiologists, P.A.
- Radiation Oncology Associates of Albuquerque
- Cancer Center of Albany Medical Center
- State University of New York Health Science Center at Brooklyn
- New York Methodist Hospital
- Roswell Park Cancer Institute
- Finger Lakes Radiation Oncology Center
- CCOP - North Shore University Hospital
- Herbert Irving Comprehensive Cancer Center
- Champlain Valley Physicians Hospital Medical Center
- Vassar Brothers Medical Center
- James P. Wilmot Cancer Center
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- Riverhill Radiation Oncology
- Lineberger Comprehensive Cancer Center, UNC
- Northeast Medical Center
- East Carolina University School of Medicine
- CCOP - Southeast Cancer Control Consortium
- Comprehensive Cancer Center at Wake Forest University
- Trinity Cancer Care Center
- Akron General Medical Center
- Akron City Hospital
- Christ Hospital
- Barrett Cancer Center, The University Hospital
- Ireland Cancer Center
- University Hospitals of Cleveland
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- Arthur G. James Cancer Hospital - Ohio State University
- CCOP - Dayton
- CCOP - Toledo Community Hospital Oncology Program
- St. Anthony Hospital
- University of Oklahoma Health Sciences Center
- St. John Health System
- CCOP - Oklahoma
- CCOP - Columbia River Program
- Lehigh Valley Hospital
- St. Luke's Hospital Cancer Center
- Geisinger Medical Center
- Mercy Fitzgerald Hospital
- Delaware County Memorial Hospital
- Pocono Cancer Center
- Milton S. Hershey Medical Center
- University of Pennsylvania Cancer Center
- Veterans Affairs Medical Center - Philadelphia
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- Fox Chase Cancer Center
- Albert Einstein Cancer Center
- University of Pittsburgh Cancer Institute
- Mercy Hospital of Pittsburgh
- Western Pennsylvania Hospital
- Reading Hospital and Medical Center
- Mercy Hospital Cancer Center - Scranton
- Wilkes Barre General Hospital
- York Hospital
- Roger Williams Medical Center/BUSM
- CCOP - Greenville
- CCOP - Upstate Carolina
- Rapid City Regional Hospital
- Jackson-Madison County General Hospital
- University of Tennessee Cancer Institute
- Vanderbilt-Ingram Cancer Center
- Harrington Cancer Center
- University of Texas Medical Branch
- University of Texas - MD Anderson Cancer Center
- Wilford Hall Medical Center
- Joe Arrington Cancer Research and Treatment Center
- Bayshore Medical Center
- Dixie Regional Medical Center
- University of Utah Health Sciences Center
- Latter Day Saints Hospital
- Vermont Cancer Center
- Cancer Center at the University of Virginia
- RMH Regional Cancer Center
- Naval Medical Center, Portsmouth
- Bon-Secours - St. Mary's Hospital
- Massey Cancer Center
- Virginia Mason Medical Center
- Deaconess Medical Center
- Yakima Valley Memorial Hospital
- Schiffler Cancer Center
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
- St. Vincent Hospital
- Gundersen Lutheran Medical Foundation
- Southern Wisconsin Radiotherapy Center
- University of Wisconsin Comprehensive Cancer Center
- Marshfield Clinic
- Community Memorial Hospital
- Columbia Hospital
- St. Luke's Medical Center
- Medical College of Wisconsin
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- All Saints Cancer Center
- Waukesha Memorial Hospital
- Tom Baker Cancer Center - Calgary
- Cross Cancer Institute
- Saint John Regional Hospital
- Newfoundland Cancer Treatment and Research Foundation
- Nova Scotia Cancer Centre
- Cancer Care Ontario-Hamilton Regional Cancer Centre
- Kingston Regional Cancer Centre
- Cancer Care Ontario-London Regional Cancer Centre
- Ottawa Regional Cancer Centre
- Northeastern Ontario Regional Cancer Centre, Sudbury
- Northwestern Ontario Regional Cancer Centre, Thunder Bay
- Toronto Sunnybrook Regional Cancer Centre
- Princess Margaret Hospital
- CHUS-Hopital Fleurimont
- Centre Hospitalier de l'Universite de Montreal
- McGill University
- Centre Hospitalier Universitaire de Quebec
- Allan Blair Cancer Centre
- Saskatoon Cancer Centre