Gemcitabine and Cisplatin in Treating Patients With Refractory or Recurrent Cancer of the Cervix
Cervical Cancer
About this trial
This is an interventional treatment trial for Cervical Cancer focused on measuring recurrent cervical cancer, stage IVB cervical cancer, stage IVA cervical cancer, cervical squamous cell carcinoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed refractory or recurrent squamous cell carcinoma of the cervix that has failed local therapy and is considered incurable Must have had 1 prior chemotherapy regimen for cervical cancer No more than 1 prior chemotherapy regimen (single or combination drug therapy), unless used as a radiosensitizer No prior chemotherapy for recurrent or persistent disease including retreatment with initial chemotherapy Bidimensionally measurable disease Ineligible for higher priority GOG protocol PATIENT CHARACTERISTICS: Age: Not specified Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: Platelet count at least lower limit of normal Absolute neutrophil count at least 1,500/mm^3 Hepatic: Bilirubin no greater than 1.5 times normal SGOT and alkaline phosphatase no greater than 3 times normal Renal: Creatinine no greater than 2.0 mg/dL Other: Not pregnant Fertile patients must use effective contraception No significant infection No other malignancies within past 5 years except nonmelanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: At least 3 weeks since prior biologic therapy for cervical cancer Chemotherapy: See Disease Characteristics At least 3 weeks since prior chemotherapy for cervical cancer and recovered No prior gemcitabine Endocrine therapy: At least 3 weeks since prior endocrine therapy for cervical cancer Radiotherapy: At least 3 weeks since prior radiotherapy for cervical cancer and recovered No prior radiotherapy to more than 25% of marrow-bearing areas Surgery: At least 3 weeks since prior surgery for cervical cancer and recovered Other: No concurrent amifostine or other protective reagents No prior anticancer therapy that contraindicates study
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- Rational Therapeutics Inc.
- Community Hospital of Los Gatos
- Chao Family Comprehensive Cancer Center
- Walter Reed Army Medical Center
- H. Lee Moffitt Cancer Center and Research Institute
- Rush-Presbyterian-St. Luke's Medical Center
- University of Illinois College of Medicine at Peoria
- Indiana University Cancer Center
- Albert B. Chandler Medical Center, University of Kentucky
- Tufts University School of Medicine
- University of Mississippi Medical Center
- Cooper Hospital/University Medical Center
- Cancer Center of Albany Medical Center
- State University of New York Health Science Center at Brooklyn
- Roswell Park Cancer Institute
- Schneider Children's Hospital at North Shore
- Memorial Sloan-Kettering Cancer Center
- Lineberger Comprehensive Cancer Center, UNC
- Duke Comprehensive Cancer Center
- Comprehensive Cancer Center at Wake Forest University
- Barrett Cancer Center, The University Hospital
- Ireland Cancer Center
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital - Ohio State University
- University of Oklahoma College of Medicine
- Abington Memorial Hospital
- Milton S. Hershey Medical Center
- University of Pennsylvania Cancer Center
- Fox Chase Cancer Center
- Simmons Cancer Center - Dallas
- Cancer Center at the University of Virginia
- Tacoma General Hospital
- Tom Baker Cancer Center - Calgary