Clinical Trials of Three Non-Drug Treatments for Winter Depression (SAD)
Seasonal Affective Disorder, Mood Disorders, Depression
About this trial
This is an interventional treatment trial for Seasonal Affective Disorder focused on measuring Seasonal Affective Disorder (SAD), Winter Depression, Mood disorders, Bipolar I and II disorders, Major Depressive Disorder, Recurrent, Light therapy, Phototherapy, Dawn Simulation therapy, Negative air ionization therapy, Chronobiology, Biological rhythms
Eligibility Criteria
Inclusion Criteria: Diagnosis of major depression or bipolar disorder, with regular onset of depression in fall or winter and remission in spring Able to maintain a regular sleep schedule Exclusion Criteria: Presence of psychiatric disorders other than major depression or bipolar depression Current use of antidepressant or recreational drugs, or psychotropic medication or supplements that may affect mood Current medical illness or medication that might interfere with response to treatment Long-distance travel during the program
Sites / Locations
- Columbia Presbyterian Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Active Comparator
Active Comparator
Placebo Comparator
Active Comparator
Experimental
bright light box
high-output negative ion generator
low-output negative ion generator
dawn simulator
dawn light pulse
30 min exposure shortly after wake-up
90 min exposure prior to wake-up
90 min exposure prior to wake-up
naturalistic incremental light exposure 90 min prior to wake-up
rectangular pulse light exposure 13 min before wake-up, matched for total illuminance with dawn signal