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S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

Primary Purpose

Lymphoma

Status

Active

Phase

Phase 3

Locations

United States

Study Type

Interventional

Intervention

rituximab

cyclophosphamide

doxorubicin

prednisone

vincristine

tositumomab

About this trial

This is an interventional treatment trial for Lymphoma focused on measuring stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Histologically confirmed previously untreated bulky stage II or stage III or IV follicular non-Hodgkin's lymphoma Grade I-III disease Cluster of differentiation antigen 20 (CD20) antigen positive Fewer than 5,000/mm^3 circulating lymphoid cells on a white blood cell (WBC) differential count Bidimensionally measurable disease Bone marrow aspiration and biopsy within the past 42 days No clinical evidence of central nervous system (CNS) involvement by lymphoma PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Zubrod 0-2 Life expectancy: Not specified Hematopoietic: See Disease Characteristics Granulocyte count greater than 1,500/mm^3 Platelet count greater than 100,000/mm^3 Hepatic: Not specified Renal: Not specified Cardiovascular: No impaired cardiac status, including: Severe coronary artery disease Cardiomyopathy Congestive heart failure Serious arrhythmia Ejection fraction at least lower limit of normal by Multi Gated Acquisition Scan (MUGA) or 2-D echocardiogram for questionable cardiac history Other: No hypersensitivity to iodine Not pregnant or nursing Fertile patients must use effective contraception during and for 6 months after study participation HIV negative No other malignancy within the past 5 years except adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix PRIOR CONCURRENT THERAPY: Biologic therapy: No prior monoclonal antibodies for cancer Chemotherapy: No prior chemotherapy for lymphoma Prior prednisone for non-lymphoma related illnesses allowed Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy for lymphoma Surgery: See Disease Characteristics

Sites / Locations

Alaska Regional Hospital Cancer Center
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Alta Bates Summit Comprehensive Cancer Center
Peninsula Medical Center
Marin Cancer Institute at Marin General Hospital
Sutter Health - Western Division Cancer Research Group
Desert Regional Medical Center Comprehensive Cancer Center
University of California Davis Cancer Center
California Pacific Medical Center - California Campus
Stanford Cancer Center
Sutter Solano Medical Center
Helen and Harry Gray Cancer Center at Hartford Hospital
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
Center for Cancer Care and Research at Watson Clinic, LLP
Sacred Heart Cancer Center at Sacred Heart Hospital
West Florida Cancer Institute at West Florida Hospital - Pensacola
Piedmont Hospital
Northside Hospital Cancer Center
Saint Joseph's Hospital of Atlanta
CCOP - Atlanta Regional
WellStar Cobb Hospital
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Dwight David Eisenhower Army Medical Center
Northeast Georgia Medical Center
Gwinnett Medical Center
Kennestone Cancer Center at Wellstar Kennestone Hospital
Southern Regional Medical Center
Pearlman Comprehensive Cancer Center at South Georgia Medical Center
Tripler Army Medical Center
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Mountain States Tumor Institute at St. Luke's Regional Medical Center
Saint Anthony's Hospital at Saint Anthony's Health Center
Rush-Copley Cancer Care Center
St. Joseph Medical Center
Graham Hospital
Memorial Hospital
University of Illinois Cancer Center
University of Chicago Cancer Research Center
Decatur Memorial Hospital Cancer Care Institute
Eureka Community Hospital
Galesburg Clinic, PC
Galesburg Cottage Hospital
Mason District Hospital
Veterans Affairs Medical Center - Hines
Hopedale Medical Complex
Joliet Oncology-Hematology Associates, Limited - West
McDonough District Hospital
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Good Samaritan Regional Health Center
Edward Hospital Cancer Center
BroMenn Regional Medical Center
Community Cancer Center
Community Hospital of Ottawa
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Cancer Treatment Center at Pekin Hospital
Proctor Hospital
CCOP - Illinois Oncology Research Association
Oncology Hematology Associates of Central Illinois, PC - Peoria
Methodist Medical Center of Illinois
OSF St. Francis Medical Center
Illinois Valley Community Hospital
Perry Memorial Hospital
St. Margaret's Hospital
Regional Cancer Center at Memorial Medical Center
Carle Cancer Center at Carle Foundation Hospital
CCOP - Carle Cancer Center
St. Francis Hospital and Health Centers - Beech Grove Campus
Elkhart General Hospital
Howard Community Hospital
Center for Cancer Therapy at LaPorte Hospital and Health Services
Saint Anthony Memorial Health Centers
Reid Hospital & Health Care Services
CCOP - Northern Indiana CR Consortium
Memorial Hospital of South Bend
Saint Joseph Regional Medical Center
Siouxland Hematology-Oncology Associates, LLP
Mercy Medical Center - Sioux City
St. Luke's Regional Medical Center
Cancer Center of Kansas, PA - Chanute
Cancer Center of Kansas, PA - Dodge City
Cancer Center of Kansas, PA - El Dorado
Cancer Center of Kansas-Independence
Providence Medical Center
Cancer Center of Kansas, PA - Kingman
Lawrence Memorial Hospital
Southwest Medical Center
Cancer Center of Kansas, PA - Newton
Menorah Medical Center
Johnson County Radiation Therapy
Cancer Center of Kansas, PA - Parsons
Cancer Center of Kansas, PA - Pratt
Cancer Center of Kansas, PA - Salina
Tammy Walker Cancer Center at Salina Regional Health Center
Shawnee Mission Medical Center
Cotton-O'Neil Cancer Center
Cancer Center of Kansas, PA - Wellington
Associates in Womens Health, PA - North Review
Cancer Center of Kansas, PA - Medical Arts Tower
Cancer Center of Kansas, PA - Wichita
CCOP - Wichita
Via Christi Cancer Center at Via Christi Regional Medical Center
Wesley Medical Center
Cancer Center of Kansas, PA - Winfield
Greenebaum Cancer Center at University of Maryland Medical Center
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
Lahey Clinic Medical Center - Burlington
Berkshire Hematology Oncology, PC
University of Michigan Comprehensive Cancer Center
Battle Creek Health System Cancer Care Center
Bay Regional Medical Center
Mecosta County Medical Center
Barbara Ann Karmanos Cancer Institute
Josephine Ford Cancer Center at Henry Ford Hospital
Butterworth Hospital at Spectrum Health
CCOP - Grand Rapids
Lacks Cancer Center at Saint Mary's Health Care
Holland Community Hospital
Borgess Medical Center
West Michigan Cancer Center
Bronson Methodist Hospital
Hackley Hospital
Lakeland Regional Cancer Care Center - St. Joseph
Oncology Care Associates, PLLC
Munson Medical Center
Metro Health Hospital
University of Mississippi Cancer Clinic
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Saint Francis Medical Center
Saint Luke's Hospital
Veterans Affairs Medical Center - Columbia (Truman Memorial)
Ellis Fischel Cancer Center at University of Missouri - Columbia
Independence Regional Health Center
Freeman Cancer Institute at Freeman Health System
St. John's Regional Medical Center
Truman Medical Center - Hospital Hill
Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City Cancer Center at St. Joseph's Medical Mall
St. Joseph Medical Center
North Kansas City Hospital
Parvin Radiation Oncology
CCOP - Kansas City
Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
Heartland Regional Medical Center
Midwest Hematology Oncology Group, Incorporated
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
CCOP - St. Louis-Cape Girardeau
David C. Pratt Cancer Center at St. John's Mercy
CCOP - Cancer Research for the Ozarks
St. John's Regional Health Center
Hulston Cancer Center at Cox Medical Center South
CCOP - Montana Cancer Consortium
Hematology-Oncology Centers of the Northern Rockies - Billings
Northern Rockies Radiation Oncology Center
St. Vincent Healthcare Cancer Care Services
Billings Clinic - Downtown
Bozeman Deaconess Cancer Center
St. James Healthcare Cancer Care
Big Sky Oncology
Great Falls Clinic - Main Facility
Sletten Cancer Institute at Benefis Healthcare
St. Peter's Hospital
Glacier Oncology, PLLC
Kalispell Medical Oncology at KRMC
Kalispell Regional Medical Center
Community Medical Center
Guardian Oncology and Center for Wellness
Montana Cancer Specialists at Montana Cancer Center
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Good Samaritan Cancer Center at Good Samaritan Hospital
UNMC Eppley Cancer Center at the University of Nebraska Medical Center
Roswell Park Cancer Institute
Tucker Center for Cancer Care at Orange Regional Medical Center
New York Weill Cornell Cancer Center at Cornell University
James P. Wilmot Cancer Center at University of Rochester Medical Center
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Duke Comprehensive Cancer Center
Wayne Memorial Hospital, Incorporated
McDowell Cancer Center at Akron General Medical Center
Mary Rutan Hospital
Adena Regional Medical Center
Good Samaritan Hospital Cancer Treatment Center
Charles M. Barrett Cancer Center at University Hospital
Cleveland Clinic Cancer Center at Fairview Hospital
Cleveland Clinic Taussig Cancer Center
Riverside Methodist Hospital Cancer Care
CCOP - Columbus
Grant Medical Center Cancer Care
Mount Carmel Health - West Hospital
Doctors Hospital at Ohio Health
Grandview Hospital
Good Samaritan Hospital
David L. Rike Cancer Center at Miami Valley Hospital
Samaritan North Cancer Care Center
Veterans Affairs Medical Center - Dayton
CCOP - Dayton
Grady Memorial Hospital
Blanchard Valley Medical Associates
Middletown Regional Hospital
Community Oncology Group at Cleveland Clinic Cancer Center
Charles F. Kettering Memorial Hospital
Fairfield Medical Center
St. Rita's Medical Center
Strecker Cancer Center at Marietta Memorial Hospital
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Mercy Medical Center
Community Hospital of Springfield and Clark County
UVMC Cancer Care Center at Upper Valley Medical Center
Mount Carmel St. Ann's Cancer Center
Clinton Memorial Hospital
Cleveland Clinic - Wooster
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Genesis - Good Samaritan Hospital
Legacy Mount Hood Medical Center
Providence Milwaukie Hospital
Legacy Good Samaritan Hospital & Comprehensive Cancer Center
Providence Cancer Center at Providence Portland Medical Center
Adventist Medical Center
CCOP - Columbia River Oncology Program
Providence St. Vincent Medical Center
Legacy Emanuel Hospital and Health Center and Children's Hospital
Legacy Meridian Park Hospital
Roper St. Francis Cancer Center at Roper Hospital
Hollings Cancer Center at Medical University of South Carolina
Palmetto Health South Carolina Cancer Center
CCOP - Greenville
Joe Arrington Cancer Research and Treatment Center
UMC Southwest Cancer and Research Center
Huntsman Cancer Institute at University of Utah
Lynchburg Hematology-Oncology Clinic
St. Joseph Cancer Center
Olympic Hematology and Oncology
St. Francis Hospital
Columbia Basin Hematology
Cascade Cancer Center at Evergreen Hospital Medical Center
Olympic Medical Center
Good Samaritan Cancer Center
Valley Medical Center
CCOP - Virginia Mason Research Center
Fred Hutchinson Cancer Research Center
Harborview Medical Center
Minor and James Medical, PLLC
Group Health Central Hospital
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Polyclinic First Hill
University Cancer Center at University of Washington Medical Center
Cancer Care Northwest - Spokane South
Franciscan Cancer Center at St. Joseph Medical Center
Allenmore Hospital
CCOP - Northwest
MultiCare Regional Cancer Center at Tacoma General Hospital
St. Clare Hospital
Southwest Washington Medical Center Cancer Center
Wenatchee Valley Medical Center
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Schiffler Cancer Center at Wheeling Hospital
Welch Cancer Center at Sheridan Memorial Hospital

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Active Comparator

Experimental

Arm Label

Arm I (CHOP only)

Arm II (CHOP + rituximab)

Arm III (CHOP + tositumomab)

Arm Description

Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on day 1. Patients also receive oral prednisone daily on days 1-5. Treatment continues every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. (Arm I closed to accrual as of 12/15/02)

Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on days 8, 29, 50, 71, 92, and 113. Patients also receive oral prednisone daily on days 8-12, 29-33, 50-54, 71-75, and 113-117 and rituximab IV over 4-6 hours on days 1, 6, 48, 90, 134, and 141.

Patients receive chemotherapy as in arm I and tositumomab (monoclonal antibody anti-B1) IV over 1 hour followed by iodine I 131 tositumomab IV over 20 minutes on days 134 and 141.

Outcomes

Primary Outcome Measures

Progression-free Survival at 2 Years

Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date

Progression-free Survival at 5 Years

Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date

Overall Survival at 2 Years

Measured from date of registration to date of death due to any cause

Overall Survival at 5 Years

Measured from date of registration to date of death due to any cause

Secondary Outcome Measures

Objective Response (Confirmed and Unconfirmed Complete and Partial Responses)

Complete Response(CR) is a complete disappearance of all disease with the exception of nodes. No new lesions. previously enlarged organs must have regressed and not be palpable. Bone marrow(BM) must be negative if positive at baseline. Normalization of markers. CR Unconfirmed (CRU) does not qualify for CR above, due to a residual nodal mass or an indeterminate BM. Partial Response(PR) is a 50% decrease in the sum of products of greatest diameters (SPD) for up to 6 identified dominant lesions, including spleenic and hepatic nodules from baseline. No new lesions and no increase in the size of liver, spleen or other nodes.

Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug

Adverse Events (AEs) are reported by the NCI Common Terminology Criteria for Adverse Events (CTCAE) version 2.0. For each patient, worst grade of each event type is reported. Grade 3 = Severe, Grade 4 = Life-threatening, Grade 5 = Fatal

Full Information

NCT ID

NCT00006721

First Posted

December 6, 2000

Last Updated

September 6, 2023

Sponsor

SWOG Cancer Research Network

Collaborators

National Cancer Institute (NCI), Cancer and Leukemia Group B, Eastern Cooperative Oncology Group

1. Study Identification

Unique Protocol Identification Number

NCT00006721

Brief Title

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

Official Title

A Phase III Trial of CHOP Plus Rituximab vs CHOP Plus Iodine-131-Labeled Monoclonal Anti-B1 Antibody (Tositumomab) for Treatment of Newly Diagnosed Follicular Non-Hodgkin's Lymphomas

Study Type

Interventional

2. Study Status

Record Verification Date

September 2023

Overall Recruitment Status

Active, not recruiting

Study Start Date

March 2001 (undefined)

Primary Completion Date

September 2011 (Actual)

Study Completion Date

March 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

SWOG Cancer Research Network

Collaborators

National Cancer Institute (NCI), Cancer and Leukemia Group B, Eastern Cooperative Oncology Group

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate tumor cells and either kill them or deliver radioactive tumor-killing substances to them without harming normal cells. It is not yet known which monoclonal antibody plus combination chemotherapy regimen is more effective in treating non-Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is comparing 2 different monoclonal antibodies given together with combination chemotherapy to see how well they work in treating patients with newly-diagnosed non-Hodgkin's lymphoma.

Detailed Description

OBJECTIVES: Compare the progression-free survival and overall survival of patients with newly diagnosed follicular non-Hodgkin's lymphoma treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without either rituximab or iodine I 131 tositumomab (monoclonal antibody anti-B1). (CHOP chemotherapy alone arm closed to accrual as of 12/15/02) Compare the response rate of these patients treated with these regimens. Compare the toxic effects of these regimens in these patients. Compare the molecular remission rates of this patient population treated with these regimens. Determine the incidence and time to development of human anti-mouse antibody positivity. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to whether microglobulin is greater than upper limit of normal (yes vs no). Patients are randomized to 1 of 3 treatment arms. (Arm I closed to accrual as of 12/15/02) Arm I (CHOP only): Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on day 1. Patients also receive oral prednisone daily on days 1-5. Treatment continues every 21 days for up to 6 courses in the absence of disease progression or unacceptable toxicity. (Arm I closed to accrual as of 12/15/02) Arm II (CHOP + rituximab): Patients receive cyclophosphamide IV over 15 minutes, doxorubicin IV over 5-20 minutes, and vincristine IV over 5-15 minutes on days 8, 29, 50, 71, 92, and 113. Patients also receive oral prednisone daily on days 8-12, 29-33, 50-54, 71-75, and 113-117 and rituximab IV over 4-6 hours on days 1, 6, 48, 90, 134, and 141. Arm III (CHOP + tositumomab): Patients receive chemotherapy as in arm I and tositumomab (monoclonal antibody anti-B1) IV over 1 hour followed by iodine I 131 tositumomab IV over 20 minutes on days 134 and 141. Patients are followed on day 200, at 1 year, every 6 months for 2 years, and then annually thereafter. PROJECTED ACCRUAL: Approximately 500 patients (250 per treatment arm) will be accrued for this study within 5.5 years. (Arm I closed to accrual as of 12/15/02)

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Lymphoma

Keywords

stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

571 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm I (CHOP only)

Arm Type

Active Comparator

Arm Description

Arm Title

Arm II (CHOP + rituximab)

Arm Type

Experimental

Arm Description

Arm Title

Arm III (CHOP + tositumomab)

Arm Type

Experimental

Arm Description

Patients receive chemotherapy as in arm I and tositumomab (monoclonal antibody anti-B1) IV over 1 hour followed by iodine I 131 tositumomab IV over 20 minutes on days 134 and 141.

Intervention Type

Biological

Intervention Name(s)

rituximab

Other Intervention Name(s)

rituxan

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

cyclophosphamide

Other Intervention Name(s)

cytoxan

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

doxorubicin

Other Intervention Name(s)

adriamycin

Intervention Description

Given IV

Intervention Type

Drug

Intervention Name(s)

prednisone

Other Intervention Name(s)

steroid

Intervention Description

Given orally

Intervention Type

Drug

Intervention Name(s)

vincristine

Other Intervention Name(s)

oncovin

Intervention Description

Given IV

Intervention Type

Radiation

Intervention Name(s)

tositumomab

Intervention Description

Given IV

Primary Outcome Measure Information:

Title

Progression-free Survival at 2 Years

Description

Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date

Time Frame

0-2 years

Title

Progression-free Survival at 5 Years

Description

Measured from time of registration to date of of first observation of progression/relapse, or death due to any cause, or last contact date

Time Frame

0-5 years

Title

Overall Survival at 2 Years

Description

Measured from date of registration to date of death due to any cause

Time Frame

0-2 years

Title

Overall Survival at 5 Years

Description

Measured from date of registration to date of death due to any cause

Time Frame

0-5 years

Secondary Outcome Measure Information:

Title

Objective Response (Confirmed and Unconfirmed Complete and Partial Responses)

Description

Time Frame

Assessed 200 days and 365 days after initiation of therapy and then every 6 months until death

Title

Number of Patients With Grade 3 Through Grade 5 Adverse Events That Are Related to Study Drug

Description

Time Frame

Patients were assessed for adverse events at end of cycle 1-6 of CHOP or R-CHOP, the end of cycle 1-6 of CHOP and once 2 weeks after the completion of I-131 treatment. For either arm, once 3 months after removal from protocol treatment

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Oliver W. Press, MD, PhD

Organizational Affiliation

Fred Hutchinson Cancer Center

Official's Role

Study Chair

First Name & Middle Initial & Last Name & Degree

Myron S. Czuczman, MD

Organizational Affiliation

Roswell Park Cancer Institute

Official's Role

Study Chair

First Name & Middle Initial & Last Name & Degree

Sandra J. Horning, MD

Organizational Affiliation

Stanford University

Official's Role

Study Chair

Facility Information:

Facility Name

Alaska Regional Hospital Cancer Center

City

Anchorage

State/Province

Alaska

ZIP/Postal Code

99508

Country

United States

Facility Name

Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital

City

Fairbanks

State/Province

Alaska

ZIP/Postal Code

99701

Country

United States

Facility Name

Hembree Mercy Cancer Center at St. Edward Mercy Medical Center

City

Fort Smith

State/Province

Arkansas

ZIP/Postal Code

72903

Country

United States

Facility Name

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Facility Name

Alta Bates Summit Comprehensive Cancer Center

City

Berkeley

State/Province

California

ZIP/Postal Code

94704

Country

United States

Facility Name

Peninsula Medical Center

City

Burlingame

State/Province

California

ZIP/Postal Code

94010

Country

United States

Facility Name

Marin Cancer Institute at Marin General Hospital

City

Greenbrae

State/Province

California

ZIP/Postal Code

94904

Country

United States

Facility Name

Sutter Health - Western Division Cancer Research Group

City

Greenbrae

State/Province

California

ZIP/Postal Code

94904

Country

United States

Facility Name

Desert Regional Medical Center Comprehensive Cancer Center

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Facility Name

University of California Davis Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95817

Country

United States

Facility Name

California Pacific Medical Center - California Campus

City

San Francisco

State/Province

California

ZIP/Postal Code

94118

Country

United States

Facility Name

Stanford Cancer Center

City

Stanford

State/Province

California

ZIP/Postal Code

94305-5824

Country

United States

Facility Name

Sutter Solano Medical Center

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Helen and Harry Gray Cancer Center at Hartford Hospital

City

Hartford

State/Province

Connecticut

ZIP/Postal Code

06102-5037

Country

United States

Facility Name

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20007

Country

United States

Facility Name

Center for Cancer Care and Research at Watson Clinic, LLP

City

Lakeland

State/Province

Florida

ZIP/Postal Code

33805

Country

United States

Facility Name

Sacred Heart Cancer Center at Sacred Heart Hospital

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32504

Country

United States

Facility Name

West Florida Cancer Institute at West Florida Hospital - Pensacola

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32514

Country

United States

Facility Name

Piedmont Hospital

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30309

Country

United States

Facility Name

Northside Hospital Cancer Center

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342-1611

Country

United States

Facility Name

Saint Joseph's Hospital of Atlanta

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342-1701

Country

United States

Facility Name

CCOP - Atlanta Regional

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342

Country

United States

Facility Name

WellStar Cobb Hospital

City

Austell

State/Province

Georgia

ZIP/Postal Code

30106

Country

United States

Facility Name

Charles B. Eberhart Cancer Center at DeKalb Medical Center

City

Decatur

State/Province

Georgia

ZIP/Postal Code

30033

Country

United States

Facility Name

Dwight David Eisenhower Army Medical Center

City

Fort Gordon

State/Province

Georgia

ZIP/Postal Code

30905-5650

Country

United States

Facility Name

Northeast Georgia Medical Center

City

Gainesville

State/Province

Georgia

ZIP/Postal Code

30501

Country

United States

Facility Name

Gwinnett Medical Center

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30045

Country

United States

Facility Name

Kennestone Cancer Center at Wellstar Kennestone Hospital

City

Marietta

State/Province

Georgia

ZIP/Postal Code

30060

Country

United States

Facility Name

Southern Regional Medical Center

City

Riverdale

State/Province

Georgia

ZIP/Postal Code

30274-2600

Country

United States

Facility Name

Pearlman Comprehensive Cancer Center at South Georgia Medical Center

City

Valdosta

State/Province

Georgia

ZIP/Postal Code

31603

Country

United States

Facility Name

Tripler Army Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96859

Country

United States

Facility Name

Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center

City

Boise

State/Province

Idaho

ZIP/Postal Code

83706

Country

United States

Facility Name

Mountain States Tumor Institute at St. Luke's Regional Medical Center

City

Boise

State/Province

Idaho

ZIP/Postal Code

83712

Country

United States

Facility Name

Saint Anthony's Hospital at Saint Anthony's Health Center

City

Alton

State/Province

Illinois

ZIP/Postal Code

62002

Country

United States

Facility Name

Rush-Copley Cancer Care Center

City

Aurora

State/Province

Illinois

ZIP/Postal Code

60504

Country

United States

Facility Name

St. Joseph Medical Center

City

Bloomington

State/Province

Illinois

ZIP/Postal Code

61701

Country

United States

Facility Name

Graham Hospital

City

Canton

State/Province

Illinois

ZIP/Postal Code

61520

Country

United States

Facility Name

Memorial Hospital

City

Carthage

State/Province

Illinois

ZIP/Postal Code

62321

Country

United States

Facility Name

University of Illinois Cancer Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612-7243

Country

United States

Facility Name

University of Chicago Cancer Research Center

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637-1470

Country

United States

Facility Name

Decatur Memorial Hospital Cancer Care Institute

City

Decatur

State/Province

Illinois

ZIP/Postal Code

62526

Country

United States

Facility Name

Eureka Community Hospital

City

Eureka

State/Province

Illinois

ZIP/Postal Code

61530

Country

United States

Facility Name

Galesburg Clinic, PC

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Galesburg Cottage Hospital

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Mason District Hospital

City

Havana

State/Province

Illinois

ZIP/Postal Code

62644

Country

United States

Facility Name

Veterans Affairs Medical Center - Hines

City

Hines

State/Province

Illinois

ZIP/Postal Code

60141

Country

United States

Facility Name

Hopedale Medical Complex

City

Hopedale

State/Province

Illinois

ZIP/Postal Code

61747

Country

United States

Facility Name

Joliet Oncology-Hematology Associates, Limited - West

City

Joliet

State/Province

Illinois

ZIP/Postal Code

60435

Country

United States

Facility Name

McDonough District Hospital

City

Macomb

State/Province

Illinois

ZIP/Postal Code

61455

Country

United States

Facility Name

Cardinal Bernardin Cancer Center at Loyola University Medical Center

City

Maywood

State/Province

Illinois

ZIP/Postal Code

60153

Country

United States

Facility Name

Good Samaritan Regional Health Center

City

Mount Vernon

State/Province

Illinois

ZIP/Postal Code

62864

Country

United States

Facility Name

Edward Hospital Cancer Center

City

Naperville

State/Province

Illinois

ZIP/Postal Code

60540

Country

United States

Facility Name

BroMenn Regional Medical Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Community Cancer Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Community Hospital of Ottawa

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

Oncology Hematology Associates of Central Illinois, PC - Ottawa

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

Cancer Treatment Center at Pekin Hospital

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61554

Country

United States

Facility Name

Proctor Hospital

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61614

Country

United States

Facility Name

CCOP - Illinois Oncology Research Association

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Oncology Hematology Associates of Central Illinois, PC - Peoria

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Methodist Medical Center of Illinois

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61636

Country

United States

Facility Name

OSF St. Francis Medical Center

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61637

Country

United States

Facility Name

Illinois Valley Community Hospital

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Perry Memorial Hospital

City

Princeton

State/Province

Illinois

ZIP/Postal Code

61356

Country

United States

Facility Name

St. Margaret's Hospital

City

Spring Valley

State/Province

Illinois

ZIP/Postal Code

61362

Country

United States

Facility Name

Regional Cancer Center at Memorial Medical Center

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62781-0001

Country

United States

Facility Name

Carle Cancer Center at Carle Foundation Hospital

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

CCOP - Carle Cancer Center

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

St. Francis Hospital and Health Centers - Beech Grove Campus

City

Beech Grove

State/Province

Indiana

ZIP/Postal Code

46107

Country

United States

Facility Name

Elkhart General Hospital

City

Elkhart

State/Province

Indiana

ZIP/Postal Code

46515

Country

United States

Facility Name

Howard Community Hospital

City

Kokomo

State/Province

Indiana

ZIP/Postal Code

46904

Country

United States

Facility Name

Center for Cancer Therapy at LaPorte Hospital and Health Services

City

La Porte

State/Province

Indiana

ZIP/Postal Code

46350

Country

United States

Facility Name

Saint Anthony Memorial Health Centers

City

Michigan City

State/Province

Indiana

ZIP/Postal Code

46360

Country

United States

Facility Name

Reid Hospital & Health Care Services

City

Richmond

State/Province

Indiana

ZIP/Postal Code

47374

Country

United States

Facility Name

CCOP - Northern Indiana CR Consortium

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46601

Country

United States

Facility Name

Memorial Hospital of South Bend

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46601

Country

United States

Facility Name

Saint Joseph Regional Medical Center

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46617

Country

United States

Facility Name

Siouxland Hematology-Oncology Associates, LLP

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51101

Country

United States

Facility Name

Mercy Medical Center - Sioux City

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51104

Country

United States

Facility Name

St. Luke's Regional Medical Center

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51104

Country

United States

Facility Name

Cancer Center of Kansas, PA - Chanute

City

Chanute

State/Province

Kansas

ZIP/Postal Code

66720

Country

United States

Facility Name

Cancer Center of Kansas, PA - Dodge City

City

Dodge City

State/Province

Kansas

ZIP/Postal Code

67801

Country

United States

Facility Name

Cancer Center of Kansas, PA - El Dorado

City

El Dorado

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Cancer Center of Kansas-Independence

City

Independence

State/Province

Kansas

ZIP/Postal Code

67301

Country

United States

Facility Name

Providence Medical Center

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66112

Country

United States

Facility Name

Cancer Center of Kansas, PA - Kingman

City

Kingman

State/Province

Kansas

ZIP/Postal Code

67068

Country

United States

Facility Name

Lawrence Memorial Hospital

City

Lawrence

State/Province

Kansas

ZIP/Postal Code

66044

Country

United States

Facility Name

Southwest Medical Center

City

Liberal

State/Province

Kansas

ZIP/Postal Code

67901

Country

United States

Facility Name

Cancer Center of Kansas, PA - Newton

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Facility Name

Menorah Medical Center

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66209

Country

United States

Facility Name

Johnson County Radiation Therapy

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66210

Country

United States

Facility Name

Cancer Center of Kansas, PA - Parsons

City

Parsons

State/Province

Kansas

ZIP/Postal Code

67357

Country

United States

Facility Name

Cancer Center of Kansas, PA - Pratt

City

Pratt

State/Province

Kansas

ZIP/Postal Code

67124

Country

United States

Facility Name

Cancer Center of Kansas, PA - Salina

City

Salina

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Tammy Walker Cancer Center at Salina Regional Health Center

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Shawnee Mission Medical Center

City

Shawnee Mission

State/Province

Kansas

ZIP/Postal Code

66204

Country

United States

Facility Name

Cotton-O'Neil Cancer Center

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Facility Name

Cancer Center of Kansas, PA - Wellington

City

Wellington

State/Province

Kansas

ZIP/Postal Code

67152

Country

United States

Facility Name

Associates in Womens Health, PA - North Review

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas, PA - Medical Arts Tower

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas, PA - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

CCOP - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Via Christi Cancer Center at Via Christi Regional Medical Center

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Wesley Medical Center

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas, PA - Winfield

City

Winfield

State/Province

Kansas

ZIP/Postal Code

67156

Country

United States

Facility Name

Greenebaum Cancer Center at University of Maryland Medical Center

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21201

Country

United States

Facility Name

Alvin and Lois Lapidus Cancer Institute at Sinai Hospital

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21215

Country

United States

Facility Name

Lahey Clinic Medical Center - Burlington

City

Burlington

State/Province

Massachusetts

ZIP/Postal Code

01805

Country

United States

Facility Name

Berkshire Hematology Oncology, PC

City

Pittsfield

State/Province

Massachusetts

ZIP/Postal Code

01201

Country

United States

Facility Name

University of Michigan Comprehensive Cancer Center

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109-0942

Country

United States

Facility Name

Battle Creek Health System Cancer Care Center

City

Battle Creek

State/Province

Michigan

ZIP/Postal Code

49017

Country

United States

Facility Name

Bay Regional Medical Center

City

Bay City

State/Province

Michigan

ZIP/Postal Code

48708

Country

United States

Facility Name

Mecosta County Medical Center

City

Big Rapids

State/Province

Michigan

ZIP/Postal Code

49307

Country

United States

Facility Name

Barbara Ann Karmanos Cancer Institute

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48201-1379

Country

United States

Facility Name

Josephine Ford Cancer Center at Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Butterworth Hospital at Spectrum Health

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

CCOP - Grand Rapids

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Lacks Cancer Center at Saint Mary's Health Care

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Holland Community Hospital

City

Holland

State/Province

Michigan

ZIP/Postal Code

49423

Country

United States

Facility Name

Borgess Medical Center

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49001

Country

United States

Facility Name

West Michigan Cancer Center

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007-3731

Country

United States

Facility Name

Bronson Methodist Hospital

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49007

Country

United States

Facility Name

Hackley Hospital

City

Muskegon

State/Province

Michigan

ZIP/Postal Code

49442

Country

United States

Facility Name

Lakeland Regional Cancer Care Center - St. Joseph

City

Saint Joseph

State/Province

Michigan

ZIP/Postal Code

49085

Country

United States

Facility Name

Oncology Care Associates, PLLC

City

Saint Joseph

State/Province

Michigan

ZIP/Postal Code

49085

Country

United States

Facility Name

Munson Medical Center

City

Traverse City

State/Province

Michigan

ZIP/Postal Code

49684

Country

United States

Facility Name

Metro Health Hospital

City

Wyoming

State/Province

Michigan

ZIP/Postal Code

49519

Country

United States

Facility Name

University of Mississippi Cancer Clinic

City

Jackson

State/Province

Mississippi

ZIP/Postal Code

39216

Country

United States

Facility Name

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital

City

Cape Girardeau

State/Province

Missouri

ZIP/Postal Code

63701

Country

United States

Facility Name

Saint Francis Medical Center

City

Cape Girardeau

State/Province

Missouri

ZIP/Postal Code

63703

Country

United States

Facility Name

Saint Luke's Hospital

City

Chesterfield

State/Province

Missouri

ZIP/Postal Code

63017

Country

United States

Facility Name

Veterans Affairs Medical Center - Columbia (Truman Memorial)

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65201

Country

United States

Facility Name

Ellis Fischel Cancer Center at University of Missouri - Columbia

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65203

Country

United States

Facility Name

Independence Regional Health Center

City

Independence

State/Province

Missouri

ZIP/Postal Code

64050

Country

United States

Facility Name

Freeman Cancer Institute at Freeman Health System

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

St. John's Regional Medical Center

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Truman Medical Center - Hospital Hill

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

Saint Luke's Cancer Institute at Saint Luke's Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64111

Country

United States

Facility Name

Kansas City Cancer Center at St. Joseph's Medical Mall

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64114

Country

United States

Facility Name

St. Joseph Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64114

Country

United States

Facility Name

North Kansas City Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64116

Country

United States

Facility Name

Parvin Radiation Oncology

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64116

Country

United States

Facility Name

CCOP - Kansas City

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64131

Country

United States

Facility Name

Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64154

Country

United States

Facility Name

Heartland Regional Medical Center

City

Saint Joseph

State/Province

Missouri

ZIP/Postal Code

64506

Country

United States

Facility Name

Midwest Hematology Oncology Group, Incorporated

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63109

Country

United States

Facility Name

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

CCOP - St. Louis-Cape Girardeau

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

David C. Pratt Cancer Center at St. John's Mercy

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

CCOP - Cancer Research for the Ozarks

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65802

Country

United States

Facility Name

St. John's Regional Health Center

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65804

Country

United States

Facility Name

Hulston Cancer Center at Cox Medical Center South

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65807

Country

United States

Facility Name

CCOP - Montana Cancer Consortium

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Hematology-Oncology Centers of the Northern Rockies - Billings

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Northern Rockies Radiation Oncology Center

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

St. Vincent Healthcare Cancer Care Services

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Billings Clinic - Downtown

City

Billings

State/Province

Montana

ZIP/Postal Code

59107-7000

Country

United States

Facility Name

Bozeman Deaconess Cancer Center

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

St. James Healthcare Cancer Care

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Big Sky Oncology

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405-5309

Country

United States

Facility Name

Great Falls Clinic - Main Facility

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Sletten Cancer Institute at Benefis Healthcare

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

St. Peter's Hospital

City

Helena

State/Province

Montana

ZIP/Postal Code

59601

Country

United States

Facility Name

Glacier Oncology, PLLC

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Kalispell Medical Oncology at KRMC

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Kalispell Regional Medical Center

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Community Medical Center

City

Missoula

State/Province

Montana

ZIP/Postal Code

59801

Country

United States

Facility Name

Guardian Oncology and Center for Wellness

City

Missoula

State/Province

Montana

ZIP/Postal Code

59804

Country

United States

Facility Name

Montana Cancer Specialists at Montana Cancer Center

City

Missoula

State/Province

Montana

ZIP/Postal Code

59807-7877

Country

United States

Facility Name

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

City

Missoula

State/Province

Montana

ZIP/Postal Code

59807

Country

United States

Facility Name

Good Samaritan Cancer Center at Good Samaritan Hospital

City

Kearney

State/Province

Nebraska

ZIP/Postal Code

68848-1990

Country

United States

Facility Name

UNMC Eppley Cancer Center at the University of Nebraska Medical Center

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68198-6805

Country

United States

Facility Name

Roswell Park Cancer Institute

City

Buffalo

State/Province

New York

ZIP/Postal Code

14263-0001

Country

United States

Facility Name

Tucker Center for Cancer Care at Orange Regional Medical Center

City

Middletown

State/Province

New York

ZIP/Postal Code

10940-4199

Country

United States

Facility Name

New York Weill Cornell Cancer Center at Cornell University

City

New York

State/Province

New York

ZIP/Postal Code

10021

Country

United States

Facility Name

James P. Wilmot Cancer Center at University of Rochester Medical Center

City

Rochester

State/Province

New York

ZIP/Postal Code

14642

Country

United States

Facility Name

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599-7295

Country

United States

Facility Name

Duke Comprehensive Cancer Center

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

Wayne Memorial Hospital, Incorporated

City

Goldsboro

State/Province

North Carolina

ZIP/Postal Code

27534

Country

United States

Facility Name

McDowell Cancer Center at Akron General Medical Center

City

Akron

State/Province

Ohio

ZIP/Postal Code

44307

Country

United States

Facility Name

Mary Rutan Hospital

City

Bellefontaine

State/Province

Ohio

ZIP/Postal Code

43311

Country

United States

Facility Name

Adena Regional Medical Center

City

Chillicothe

State/Province

Ohio

ZIP/Postal Code

45601

Country

United States

Facility Name

Good Samaritan Hospital Cancer Treatment Center

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45220

Country

United States

Facility Name

Charles M. Barrett Cancer Center at University Hospital

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45267

Country

United States

Facility Name

Cleveland Clinic Cancer Center at Fairview Hospital

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44111

Country

United States

Facility Name

Cleveland Clinic Taussig Cancer Center

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44195

Country

United States

Facility Name

Riverside Methodist Hospital Cancer Care

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43214-3998

Country

United States

Facility Name

CCOP - Columbus

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Grant Medical Center Cancer Care

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Mount Carmel Health - West Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43222

Country

United States

Facility Name

Doctors Hospital at Ohio Health

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43228

Country

United States

Facility Name

Grandview Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45405

Country

United States

Facility Name

Good Samaritan Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45406

Country

United States

Facility Name

David L. Rike Cancer Center at Miami Valley Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45409

Country

United States

Facility Name

Samaritan North Cancer Care Center

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45415

Country

United States

Facility Name

Veterans Affairs Medical Center - Dayton

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45428

Country

United States

Facility Name

CCOP - Dayton

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45429

Country

United States

Facility Name

Grady Memorial Hospital

City

Delaware

State/Province

Ohio

ZIP/Postal Code

43015

Country

United States

Facility Name

Blanchard Valley Medical Associates

City

Findlay

State/Province

Ohio

ZIP/Postal Code

45840

Country

United States

Facility Name

Middletown Regional Hospital

City

Franklin

State/Province

Ohio

ZIP/Postal Code

45005-1066

Country

United States

Facility Name

Community Oncology Group at Cleveland Clinic Cancer Center

City

Independence

State/Province

Ohio

ZIP/Postal Code

44131

Country

United States

Facility Name

Charles F. Kettering Memorial Hospital

City

Kettering

State/Province

Ohio

ZIP/Postal Code

45429

Country

United States

Facility Name

Fairfield Medical Center

City

Lancaster

State/Province

Ohio

ZIP/Postal Code

43130

Country

United States

Facility Name

St. Rita's Medical Center

City

Lima

State/Province

Ohio

ZIP/Postal Code

45801

Country

United States

Facility Name

Strecker Cancer Center at Marietta Memorial Hospital

City

Marietta

State/Province

Ohio

ZIP/Postal Code

45750

Country

United States

Facility Name

Licking Memorial Cancer Care Program at Licking Memorial Hospital

City

Newark

State/Province

Ohio

ZIP/Postal Code

43055

Country

United States

Facility Name

Mercy Medical Center

City

Springfield

State/Province

Ohio

ZIP/Postal Code

45504

Country

United States

Facility Name

Community Hospital of Springfield and Clark County

City

Springfield

State/Province

Ohio

ZIP/Postal Code

45505

Country

United States

Facility Name

UVMC Cancer Care Center at Upper Valley Medical Center

City

Troy

State/Province

Ohio

ZIP/Postal Code

45373-1300

Country

United States

Facility Name

Mount Carmel St. Ann's Cancer Center

City

Westerville

State/Province

Ohio

ZIP/Postal Code

43081

Country

United States

Facility Name

Clinton Memorial Hospital

City

Wilmington

State/Province

Ohio

ZIP/Postal Code

45177

Country

United States

Facility Name

Cleveland Clinic - Wooster

City

Wooster

State/Province

Ohio

ZIP/Postal Code

44691

Country

United States

Facility Name

Ruth G. McMillan Cancer Center at Greene Memorial Hospital

City

Xenia

State/Province

Ohio

ZIP/Postal Code

45385

Country

United States

Facility Name

Genesis - Good Samaritan Hospital

City

Zanesville

State/Province

Ohio

ZIP/Postal Code

43701

Country

United States

Facility Name

Legacy Mount Hood Medical Center

City

Gresham

State/Province

Oregon

ZIP/Postal Code

97030

Country

United States

Facility Name

Providence Milwaukie Hospital

City

Milwaukie

State/Province

Oregon

ZIP/Postal Code

97222

Country

United States

Facility Name

Legacy Good Samaritan Hospital & Comprehensive Cancer Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97210

Country

United States

Facility Name

Providence Cancer Center at Providence Portland Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97213-2967

Country

United States

Facility Name

Adventist Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97216

Country

United States

Facility Name

CCOP - Columbia River Oncology Program

City

Portland

State/Province

Oregon

ZIP/Postal Code

97225

Country

United States

Facility Name

Providence St. Vincent Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97225

Country

United States

Facility Name

Legacy Emanuel Hospital and Health Center and Children's Hospital

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Legacy Meridian Park Hospital

City

Tualatin

State/Province

Oregon

ZIP/Postal Code

97062

Country

United States

Facility Name

Roper St. Francis Cancer Center at Roper Hospital

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29401

Country

United States

Facility Name

Hollings Cancer Center at Medical University of South Carolina

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29425

Country

United States

Facility Name

Palmetto Health South Carolina Cancer Center

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29203

Country

United States

Facility Name

CCOP - Greenville

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Facility Name

Joe Arrington Cancer Research and Treatment Center

City

Lubbock

State/Province

Texas

ZIP/Postal Code

79410-1894

Country

United States

Facility Name

UMC Southwest Cancer and Research Center

City

Lubbock

State/Province

Texas

ZIP/Postal Code

79415-3364

Country

United States

Facility Name

Huntsman Cancer Institute at University of Utah

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

Lynchburg Hematology-Oncology Clinic

City

Lynchburg

State/Province

Virginia

ZIP/Postal Code

24501

Country

United States

Facility Name

St. Joseph Cancer Center

City

Bellingham

State/Province

Washington

ZIP/Postal Code

98225

Country

United States

Facility Name

Olympic Hematology and Oncology

City

Bremerton

State/Province

Washington

ZIP/Postal Code

98310

Country

United States

Facility Name

St. Francis Hospital

City

Federal Way

State/Province

Washington

ZIP/Postal Code

98003

Country

United States

Facility Name

Columbia Basin Hematology

City

Kennewick

State/Province

Washington

ZIP/Postal Code

99336

Country

United States

Facility Name

Cascade Cancer Center at Evergreen Hospital Medical Center

City

Kirkland

State/Province

Washington

ZIP/Postal Code

98033

Country

United States

Facility Name

Olympic Medical Center

City

Port Angeles

State/Province

Washington

ZIP/Postal Code

98362

Country

United States

Facility Name

Good Samaritan Cancer Center

City

Puyallup

State/Province

Washington

ZIP/Postal Code

98372

Country

United States

Facility Name

Valley Medical Center

City

Renton

State/Province

Washington

ZIP/Postal Code

98055

Country

United States

Facility Name

CCOP - Virginia Mason Research Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98101

Country

United States

Facility Name

Fred Hutchinson Cancer Research Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Facility Name

Harborview Medical Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Facility Name

Minor and James Medical, PLLC

City

Seattle

State/Province

Washington

ZIP/Postal Code

98104

Country

United States

Facility Name

Group Health Central Hospital

City

Seattle

State/Province

Washington

ZIP/Postal Code

98112

Country

United States

Facility Name

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus

City

Seattle

State/Province

Washington

ZIP/Postal Code

98122-4307

Country

United States

Facility Name

Polyclinic First Hill

City

Seattle

State/Province

Washington

ZIP/Postal Code

98122

Country

United States

Facility Name

University Cancer Center at University of Washington Medical Center

City

Seattle

State/Province

Washington

ZIP/Postal Code

98195-6043

Country

United States

Facility Name

Cancer Care Northwest - Spokane South

City

Spokane

State/Province

Washington

ZIP/Postal Code

99202

Country

United States

Facility Name

Franciscan Cancer Center at St. Joseph Medical Center

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405-3004

Country

United States

Facility Name

Allenmore Hospital

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

CCOP - Northwest

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

MultiCare Regional Cancer Center at Tacoma General Hospital

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

St. Clare Hospital

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98499

Country

United States

Facility Name

Southwest Washington Medical Center Cancer Center

City

Vancouver

State/Province

Washington

ZIP/Postal Code

98668

Country

United States

Facility Name

Wenatchee Valley Medical Center

City

Wenatchee

State/Province

Washington

ZIP/Postal Code

98801-2028

Country

United States

Facility Name

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

City

Yakima

State/Province

Washington

ZIP/Postal Code

98902

Country

United States

Facility Name

Schiffler Cancer Center at Wheeling Hospital

City

Wheeling

State/Province

West Virginia

ZIP/Postal Code

26003

Country

United States

Facility Name

Welch Cancer Center at Sheridan Memorial Hospital

City

Sheridan

State/Province

Wyoming

ZIP/Postal Code

82801

Country

United States

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

https://swog.org/Visitors/Download/Policies/Policy43.pdf

Citations:

PubMed Identifier

29356608

Citation

Shadman M, Li H, Rimsza L, Leonard JP, Kaminski MS, Braziel RM, Spier CM, Gopal AK, Maloney DG, Cheson BD, Dakhil S, LeBlanc M, Smith SM, Fisher RI, Friedberg JW, Press OW. Continued Excellent Outcomes in Previously Untreated Patients With Follicular Lymphoma After Treatment With CHOP Plus Rituximab or CHOP Plus 131I-Tositumomab: Long-Term Follow-Up of Phase III Randomized Study SWOG-S0016. J Clin Oncol. 2018 Mar 1;36(7):697-703. doi: 10.1200/JCO.2017.74.5083. Epub 2018 Jan 22.

Results Reference

derived

PubMed Identifier

23233710

Citation

Press OW, Unger JM, Rimsza LM, Friedberg JW, LeBlanc M, Czuczman MS, Kaminski M, Braziel RM, Spier C, Gopal AK, Maloney DG, Cheson BD, Dakhil SR, Miller TP, Fisher RI. Phase III randomized intergroup trial of CHOP plus rituximab compared with CHOP chemotherapy plus (131)iodine-tositumomab for previously untreated follicular non-Hodgkin lymphoma: SWOG S0016. J Clin Oncol. 2013 Jan 20;31(3):314-20. doi: 10.1200/JCO.2012.42.4101. Epub 2012 Dec 10.

Results Reference

derived

Learn more about this trial

S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma

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