Combination Chemotherapy Plus Bevacizumab in Treating Patients With Advanced Colorectal Cancer
Colorectal Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring stage IV colon cancer, stage IV rectal cancer, recurrent colon cancer, recurrent rectal cancer, adenocarcinoma of the colon, adenocarcinoma of the rectum
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed advanced or metastatic adenocarcinoma of the colon and rectum Surgically unresectable disease Measurable disease Disease outside the prior radiotherapy port and/or progressive disease within the previously irradiated volume PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: WBC at least 3,000/mm3 Platelet count at least 100,000/mm3 No hemorrhagic events within the past 6 months Hepatic: Bilirubin normal SGOT normal INR no greater than 1.5 Renal: Creatinine no greater than 1.5 times upper limit of normal Cardiovascular: No thromboembolic events within the past 6 months Pulmonary: No evidence of pneumonia Other: No known hypersensitivity to recombinant humanized murine monoclonal antibodies No evidence of significant active infection (e.g., peritonitis or wound abscess) Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent sargramostim (GM-CSF) Chemotherapy: At least 12 months since prior fluorouracil-based adjuvant chemotherapy No prior adjuvant irinotecan Endocrine therapy: Not specified Radiotherapy: See Disease Characteristics At least 2 weeks since prior radiotherapy and recovered Surgery: See Disease Characteristics Other: No prior therapy for advanced disease No concurrent therapeutic anticoagulation except for low-dose coumadin for maintenance of indwelling catheters
Sites / Locations
- CCOP - Scottsdale Oncology Program
- Cancer Center and Beckman Research Institute, City of Hope
- Veterans Affairs Medical Center - Palo Alto
- Stanford University Medical Center
- CCOP - Colorado Cancer Research Program, Inc.
- CCOP - Christiana Care Health Services
- MBCCOP-Howard University Cancer Center
- Walter Reed Army Medical Center
- Veterans Affairs Medical Center - Gainsville
- Veterans Affairs Medical Center - Miami
- H. Lee Moffitt Cancer Center and Research Institute
- Veterans Affairs Medical Center - Tampa (Haley)
- Emory University Hospital - Atlanta
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University
- Veterans Affairs Medical Center - Lakeside Chicago
- CCOP - Central Illinois
- CCOP - Evanston
- CCOP - Illinois Oncology Research Association
- CCOP - Carle Cancer Center
- Indiana University Cancer Center
- Veterans Affairs Medical Center - Indianapolis (Roudebush)
- CCOP - Cedar Rapids Oncology Project
- CCOP - Iowa Oncology Research Association
- Holden Comprehensive Cancer Center at The University of Iowa
- Veterans Affairs Medical Center - Wichita
- MBCCOP - LSU Health Sciences Center
- CCOP - Ochsner
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- New England Medical Center Hospital
- Beth Israel Deaconess Medical Center
- CCOP - Ann Arbor Regional
- CCOP - Kalamazoo
- CCOP - Duluth
- Veterans Affairs Medical Center - Minneapolis
- University of Minnesota Cancer Center
- Mayo Clinic Cancer Center
- CCOP - Metro-Minnesota
- Veterans Affairs Medical Center - Omaha
- CCOP - Missouri Valley Cancer Consortium
- CCOP - Southern Nevada Cancer Research Foundation
- Veterans Affairs Medical Center - East Orange
- CCOP - Northern New Jersey
- Cancer Institute of New Jersey
- Veterans Affairs Medical Center - Albany
- Albert Einstein Comprehensive Cancer Center
- MBCCOP-Our Lady of Mercy Cancer Center
- Veterans Affairs Medical Center - Brooklyn
- Veterans Affairs Medical Center - New York
- NYU School of Medicine's Kaplan Comprehensive Cancer Center
- University of Rochester Cancer Center
- CCOP - Merit Care Hospital
- Ireland Cancer Center
- Veterans Affairs Medical Center - Cleveland
- Cleveland Clinic Taussig Cancer Center
- CCOP - Columbus
- CCOP - Toledo Community Hospital Oncology Program
- CCOP - Sooner State
- CCOP - Geisinger Clinic and Medical Center
- Hahnemann University Hospital
- University of Pennsylvania Cancer Center
- University of Pennsylvania Health Systems
- Fox Chase Cancer Center
- University of Pittsburgh Cancer Institute
- Veterans Affairs Medical Center - Pittsburgh
- CCOP - MainLine Health
- CCOP - Sioux Community Cancer Consortium
- Veterans Affairs Medical Center - Nashville
- Vanderbilt-Ingram Cancer Center
- Veterans Affairs Medical Center - Madison
- University of Wisconsin Comprehensive Cancer Center
- CCOP - Marshfield Medical Research and Education Foundation
- Medical College of Wisconsin
- Veterans Affairs Medical Center - Milwaukee (Zablocki)
- MBCCOP - San Juan
- Veterans Affairs Medical Center - San Juan
- Pretoria Academic Hospitals