Capecitabine in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal Cavity Cancer
Ovarian Cancer, Primary Peritoneal Cavity Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring recurrent ovarian epithelial cancer, primary peritoneal cavity cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically proven recurrent ovarian epithelial or primary peritoneal cavity cancer Measurable disease At least 1 unidimensionally measurable lesion Ascites and pleural effusions are not considered measurable disease Prior therapy must include 1 platinum-based chemotherapy regimen for primary disease containing carboplatin, cisplatin, or another organoplatinum compound Treatment-free interval of 6-12 months after response to platinum therapy Not eligible for higher priority GOG protocol PATIENT CHARACTERISTICS: Age: Any age Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: Absolute neutrophil count at least 1,500/mm^3 Platelet count at least lower limit of normal Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN) SGOT no greater than 2.5 times ULN Alkaline phosphatase no greater than 2.5 times ULN Renal: Creatinine clearance at least 50 mL/min Other: Not pregnant Negative pregnancy test Fertile patients must use effective contraception No neuropathy (sensory and motor) greater than grade 1 No other malignancy within the past 5 years except nonmelanoma skin cancer No concurrent active infection requiring antibiotics PRIOR CONCURRENT THERAPY: Biologic therapy: At least 3 weeks since prior biologic or immunologic therapy No concurrent prophylactic filgrastim (G-CSF) Chemotherapy: See Disease Characteristics If no prior therapy with paclitaxel, a second regimen including paclitaxel allowed No prior capecitabine or fluorouracil No prior chemotherapy for recurrent or persistent disease, including pretreatment with initial chemotherapy regimens Recovered from prior chemotherapy Endocrine therapy: At least 1 week since prior hormonal therapy directed at malignant tumor Concurrent continuation of hormone replacement therapy allowed Radiotherapy: At least 3 weeks since prior radiotherapy and recovered No prior radiotherapy to site(s) of measurable disease No prior radiotherapy to more than 25% of bone marrow Surgery: Recovered from prior surgery Other: No prior cancer treatment that would preclude study therapy No concurrent amifostine or other protective reagents
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- USC/Norris Comprehensive Cancer Center and Hospital
- Jonsson Comprehensive Cancer Center, UCLA
- Chao Family Comprehensive Cancer Center
- University of Colorado Cancer Center
- H. Lee Moffitt Cancer Center and Research Institute
- Rush-Presbyterian-St. Luke's Medical Center
- Indiana University Cancer Center
- Holden Comprehensive Cancer Center at The University of Iowa
- Radiation Oncology Branch
- Tufts University School of Medicine
- University of Massachusetts Memorial Medical Center
- University of Minnesota Cancer Center
- Mayo Clinic Cancer Center
- Ellis Fischel Cancer Center - Columbia
- Washington University School of Medicine
- Cooper Hospital/University Medical Center
- State University of New York Health Science Center at Brooklyn
- Memorial Sloan-Kettering Cancer Center
- State University of New York Health Sciences Center - Stony Brook
- Lineberger Comprehensive Cancer Center, UNC
- Duke Comprehensive Cancer Center
- Comprehensive Cancer Center at Wake Forest University
- Cleveland Clinic Taussig Cancer Center
- Arthur G. James Cancer Hospital - Ohio State University
- University of Oklahoma College of Medicine
- Abington Memorial Hospital
- Milton S. Hershey Medical Center
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia
- University of Texas - MD Anderson Cancer Center
- Tom Baker Cancer Center - Calgary