Safety and Immune Response Study of the Vaccine ALVAC vCP1452 Alone or in Combination With AIDSVAX B/B
HIV Infections
About this trial
This is an interventional prevention trial for HIV Infections focused on measuring Drug Therapy, Combination, HIV Envelope Protein gp120, AIDS Vaccines, CD8-Positive T-Lymphocytes, HIV Seronegativity, AIDSVAX, HIV Preventive Vaccine
Eligibility Criteria
Inclusion Criteria Volunteers may be eligible for this study if they: Are HIV-negative. Are 18 to 60 years old. Have a CD4 cell count of 400 cells/mm3 or more. Agree to use adequate birth control for 1 month before study entry and during the study (female participants). Have a normal history and physical examination. Are available for 12 months of follow-up for the planned duration of the study. Have a negative pregnancy test within 3 days prior to injections. Exclusion Criteria Volunteers will not be eligible for this study if they: Are pregnant or breast-feeding. Have chronic hepatitis B. Are taking medications that affect the immune system. Have an immune system problem, any long-term illness, or any autoimmune disease. Have cancer, except if it has been removed with surgery and cure is likely. Have a physical condition, mental condition, or job or work that may interfere with the study. Have been suicidal, or have ever needed medicines for a serious mental condition. Have received certain vaccines within 60 days of study entry. Have used experimental drugs within 30 days prior to study entry. Have received any blood products, such as immunoglobulin, in the last 6 months. Have active syphilis. Have active tuberculosis. Have history of severe allergy or any serious reactions to vaccines. Have had HIV-1 vaccines in a clinical study.
Sites / Locations
- Alabama Vaccine CRS
- San Francisco Dept. of Public Health, San Francisco Gen. Hosp.
- San Francisco Vaccine and Prevention CRS
- Project Brave HIV Vaccine CRS
- Johns Hopkins Bloomberg School of Public Health, Ctr. for Immunization Research, Project SAVE-DC
- Johns Hopkins Bloomberg School of Public Health,Ctr for Immunization Research,Project SAVE-Baltimore
- Brigham and Women's Hosp. CRS
- Fenway Community Health Clinical Research Site (FCHCRS)
- Saint Louis Univ. School of Medicine, HVTU
- NY Blood Ctr./Bronx CRS
- HIV Prevention & Treatment CRS
- NY Blood Ctr./Union Square CRS
- Univ. of Rochester HVTN CRS
- Miriam Hospital's HVTU
- Vanderbilt Vaccine CRS
- Infectious Diseases Physicians, Inc.
- FHCRC/UW Vaccine CRS