Safety and Effectiveness of the Vaccine ALVAC-HIV vCP205 in HIV-Negative Adult Volunteers in Uganda

Inclusion Criteria Volunteers may be eligible for this study if they: Are 18 to 40 years of age. Have a negative pregnancy test at time of entry and agree to use birth control for 1 month prior to the first injection and during active follow-up. Have a normal history and physical examination. Are negative for Hepatitis B. Are HIV-negative. Have blood cells that can be infected with Epstein-Barr virus. Are available for follow-up for the study (24 months). Exclusion Criteria Volunteers will not be eligible for this study if they: Have had a sexually transmitted disease or more than 1 sex partner during the previous 12 months. Are pregnant or breast-feeding. Have had immune diseases, chronic illness, or malignancy. Persons who had cancer that was surgically removed and are thought to be cured are eligible. Have used medications that affect the immune system. Have a medical or mental condition or job that may interfere with the study. Have received certain live vaccines within 60 days of study. Other vaccines such as flu or pneumococcal are not excluded but should be received at least 2 weeks away from HIV immunizations. Have used experimental agents within 30 days prior to study. Have received any blood products within the last 6 months. Have syphilis. Have an HIV-positive partner. Have tuberculosis. Have had or currently have severe allergic reactions to vaccines, eggs or neomycin, or any other substance. that required hospitalization or other medical care. Have been immunized or treated for rabies within 6 months of receiving injections. Are poultry workers. Have malaria that has not been treated or has not responded to treatment. Have schistosomiasis.