Monoclonal Antibody Therapy in Treating Patients With Recurrent or Refractory Lymphoma
Lymphoma

About this trial
This is an interventional treatment trial for Lymphoma focused on measuring recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult Burkitt lymphoma, recurrent mantle cell lymphoma, recurrent small lymphocytic lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed recurrent or refractory B-cell lymphoma after at least 1 standard chemotherapy regimen Low, intermediate, or high grade CD22 antigen on at least 30% of tumor cells by flow cytometry No lymphoblastic lymphoma, B-cell chronic lymphocytic leukemia, B-cell or pre-B-cell acute lymphocytic leukemia, or hairy cell leukemia Measurable disease Positive bone marrow not considered measurable Circulating tumor cells in peripheral blood considered measurable No CNS disease (leptomeningeal or parenchymal) No lymphomatous or infectious pulmonary parenchymal disease No baseline/pleural effusion Ineligible for or refused autologous or allogeneic bone marrow transplantation NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-2 Life expectancy: At least 3 months Hematopoietic: Platelet count greater than 50,000/mm^3 Absolute granulocyte count greater than 750/mm^3 Hepatic: Bilirubin less than 1.5 mg/dL SGPT less than 2 times upper limit of normal Albumin greater than 75% lower limit of normal Renal: Creatinine no greater than 1.4 mg/dL OR Creatinine clearance at least 60 mL/min Cardiovascular: Ejection fraction greater than 40% by MUGA or echocardiogram Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception HIV negative No human anti-mouse antibody (HAMA) levels greater than 1 microgram/mL No condition that may require stenting of ureters, stabilization of impending pathological fractures, or relief of airway, bowel, or biliary tract obstruction No other concurrent illness that would preclude study PRIOR CONCURRENT THERAPY: Biologic therapy: See Disease Characteristics Chemotherapy: See Disease Characteristics At least 2 weeks since prior chemotherapy and recovered No concurrent chemotherapy Endocrine therapy: No concurrent corticosteroids unless receiving stable maintenance dose prior to therapy Radiotherapy: No prior radiotherapy No concurrent radiotherapy Surgery: Not specified Other: No other concurrent investigational agents
Sites / Locations
- Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
- Center for Cancer Research