Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant

Inclusion Criteria: Patients with severe combined immunodeficiency syndrome: SCID with presence of B lymphocytes X-linked SCID (presence of B lymphocytes) Autosomal recessive SCID Patients with severe combined immunodeficiency syndrome: SCID with absence of T and B lymphocytes Patients with severe combined immunodeficiency syndrome: Purine metabolite deficiencies, deficiencies of the purine metabolites Adenosine deaminase (ADA) deficiency Purine nucleoside phosphorylase (PNP) deficiency DONOR: Related donor who is human leukocyte antigen (HLA) genotypically identical at least at one haplotype and may be genotypically or phenotypically identical for serological typing for HLA-A, B, C, and at the allele level for DRB1 and DQB1; related donors other than siblings must be matched at HLA-A, B, and C (at highest resolution available at the time of donor selection) and at DRB1 and DQB1 by deoxyribonucleic acid (DNA) typing; if more than one HLA-identical sibling is available, priority will be given to the oldest normal donor DONOR: Unrelated donors who are prospectively matched for HLA-A, B, C, DRB1 and DQB1 by DNA typing at the highest resolution routinely available at the time of donor selection; only a single allele disparity will be allowed for HLA-A, B, or C as defined by high resolution typing Exclusion Criteria: Patients with viral associated T cell immunodeficiency disorders, such as human immunodeficiency virus (HIV) Patients with other disease or organ dysfunction that would limit survival to less than 30 days DONOR: Identical twin DONOR: Pregnancy DONOR: HIV seropositive DONOR: A positive anti-donor cytotoxic cross match is absolute donor exclusion DONOR: Patient and donor pairs homozygous at a mismatched allele in the graft rejection vector are considered a two-HLA allele mismatch, i.e., the patient is A*0201, and this type of mismatch is not allowed DONOR: < 6 months old, > 75 years old