Capsaicin to Control Pain Following Third Molar Extraction
Facial Pain
About this trial
This is an interventional treatment trial for Facial Pain focused on measuring Preemptive Analgesia, Vanilloid, Vanilloid Receptor (VR), Capsaicin, Acute Pain, Orofacial, Visual Analog Scale (VAS), Resiniferatoxin, Healthy Volunteer, Wisdom Teeth, Pain
Eligibility Criteria
INCLUSION CRITERIA: Male or female volunteers referred for mandibular third molar extraction with a minimal difficulty rating score of 3-4; the rating will be verified by the oral surgeon at time of surgery. Age between 16-40. ASA status 1 or 2, deemed in good general health (able to tolerate outpatient conscious sedation safely). Willing to return at 24 hours for extraction of 1 tooth and be willing to wait up to 6 hours for post op observation following tooth extraction. Willing to return another 48 hours later for final sensory testing. EXCLUSION CRITERIA: ASA status 3-5 and Emergency operation (E) that do not get a physician clearance; i.e. systemic disturbances that limits the patient's activity. Pregnant or breast-feeding mothers. Allergy to investigational drugs or to red chili peppers. Chronically use of analgesics (not limited to, but including: non-steroidal anti-inflammatory medications, steroids, anti-depressants, anti-convulsants). Presence of chronic disease (e.g. cardiovascular disease, liver disease, kidney disease, diabetes, etc.)
Sites / Locations
- National Institute of Dental And Craniofacial Research (NIDCR)