Monoclonal Antibody Therapy, Paclitaxel, and Cyclosporine in Treating Patients With Recurrent or Refractory Non-Hodgkin's Lymphoma
Lymphoma
About this trial
This is an interventional treatment trial for Lymphoma focused on measuring recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult Burkitt lymphoma, recurrent mantle cell lymphoma, recurrent marginal zone lymphoma, recurrent small lymphocytic lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginal zone B-cell lymphoma, splenic marginal zone lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of non-Hodgkin's lymphoma (NHL) that has failed standard first-line chemotherapy Measurable disease NHL tissue Lym-1 reactive in vitro Normocellular bone marrow as evidenced by less than 25% of the bone marrow being NHL by bilateral bone marrow biopsy No bone marrow evidence of myelodysplastic syndrome HAMA titer negative PATIENT CHARACTERISTICS: Age: 18 and over Performance status: Karnofsky 70-100% Life expectancy: 3 to 6 months Hematopoietic: Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 130,000/mm^3 Hepatic: Bilirubin no greater than 1.5 mg/dL AST no greater than 84 U/L Renal: Creatinine less than 1.5 mg/dL OR Creatinine clearance at least 50 mL/min Cardiovascular: LVEF at least 50% Pulmonary: FEV1 at least 60% of predicted FVC at least 60% of predicted DLCO at least 50% Other: No other prior malignancy within the past 5 years except for nonmelanoma skin cancer HIV negative Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics At least 4 weeks since prior chemotherapy Endocrine therapy: Not specified Radiotherapy: At least 4 weeks since prior external beam radiotherapy Surgery: Not specified
Sites / Locations
- University of California Davis Cancer Center