Carboplatin Combined With Paclitaxel in Treating Patients With Advanced Thymoma
Thymoma, Thymic Carcinoma
About this trial
This is an interventional treatment trial for Thymoma focused on measuring thymoma, thymic carcinoma
Eligibility Criteria
Inclusion Criteria: Histologically confirmed invasive, recurrent, or metastatic thymoma or thymic carcinoma not amenable to potentially curative therapy by surgery Extensive disease (distant disease, pleural disease, pulmonary with or without mediastinal disease, or recurrent progressive disease in site of prior radiotherapy) Advanced limited disease allowed if ineligible for primary radiotherapy or surgery Measurable disease Age 18 and over ECOG Performance Status 0-1 Granulocyte count at least 1,500 cells/mm^3 Platelet count at least 100,000 cells/mm^3 Bilirubin no greater than 1.5 mg/dL Creatinine no greater than 2.0 mg/dL Concurrent corticosteroids for myasthenia gravis or other chronic conditions allowed Exclusion Criteria: Acute concurrent complications such as infection or post-surgical complications Other prior malignancy within the past 5 years unless curatively treated with no evidence of recurrence Pregnant or nursing. A negative pregnancy test was required, and fertile patients must use effective contraception Prior chemotherapy for metastatic disease. Prior preoperative or adjuvant chemotherapy allowed if disease-free survival prior to recurrence was more than 1 year
Sites / Locations
- Rush-Copley Cancer Care Center
- Joliet Oncology-Hematology Associates, Limited - West
- Swedish-American Regional Cancer Center
- Carle Cancer Center at Carle Foundation Hospital
- CCOP - Carle Cancer Center
- Saint Anthony Memorial Health Centers
- Cedar Rapids Oncology Associates
- Siouxland Hematology-Oncology Associates, LLP
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Green Bay Oncology, Limited - Escanaba
- Dickinson County Healthcare System
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- Meeker County Memorial Hospital
- HealthEast Cancer Care at St. John's Hospital
- Minnesota Oncology Hematology, PA - Maplewood
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
- CCOP - Metro-Minnesota
- Park Nicollet Cancer Center
- Regions Hospital Cancer Care Center
- HealthEast Cancer Care at St. Joseph's Hospital
- United Hospital
- St. Francis Cancer Center at St. Francis Medical Center
- Ridgeview Medical Center
- HealthEast Cancer Care at Woodwinds Health Campus
- Minnesota Oncology Hematology, PA - Woodbury
- Hunterdon Regional Cancer Center at Hunterdon Medical Center
- CCOP - Northern New Jersey
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- Aultman Cancer Center at Aultman Hospital
- Case Comprehensive Cancer Center
- MetroHealth Cancer Care Center at MetroHealth Medical Center
- St. Rita's Medical Center
- Mercy Fitzgerald Hospital
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Lewistown Hospital
- Riddle Memorial Hospital Cancer Center
- Fox Chase Cancer Center - Philadelphia
- Albert Einstein Cancer Center
- Hematology and Oncology Associates of Northeastern Pennsylvania
- Mount Nittany Medical Center
- Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
- Rapid City Regional Hospital
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sanford Cancer Center at Sanford USD Medical Center
- Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Froedtert Hospital and Medical College of Wisconsin
- Medical College of Wisconsin Cancer Center
- Green Bay Oncology, Limited - Oconto Falls
- Marshfield Clinic - Indianhead Center
- Green Bay Oncology, Limited - Sturgeon Bay
Arms of the Study
Arm 1
Experimental
Paclitaxel plus Carboplatin
Paclitaxel 225 mg/m2 IV over 3 hours and Carboplatin AUC 6.0 IV over 30 minutes on day 1 of a 21-day cycle