Catecholamine Reserve and Exercise Tolerance in Healthy Volunteers and Patients With Congenital Adrenal Hyperplasia
Congenital Adrenal Hyperplasia, Healthy
About this trial
This is an observational trial for Congenital Adrenal Hyperplasia focused on measuring CAH, Catecholamines, Adrenal Medulla, Endocrine, Congenital Adrenal Hyperplasia, Exercise, Healthy Volunteer
Eligibility Criteria
INCLUSION CRITERIA: Age: 9-40 years. CAH patients on conventional therapy (glucocorticoids, mineralocorticoids) in good clinical management as defined by the following criteria: 17-OH-progesterone level between 100 and 1500 ng/dL; Plasma renin activity normal; Growth rate within 2 SD for age (children); No new signs or symptoms of virilization (clitoral growth, voice deepening) for females. Healthy volunteers will be matched for age, sex, race and body fat. EXCLUSION CRITERIA: Inability to understand or comply with instructions related to the study (as judged by investigator). Chronic medical conditions other than congenital adrenal hyperplasia except mild conditions (e.g. allergic rhinitis, migraine headaches) will be excluded provided the subjects are not acutely ill and do not require medication for this condition during the study. Acute medical conditions including intercurrent infection and fever in the preceding 7 days. Positive pregnancy test. CAH patients on flutamide. Tylenol or other acetaminophen-containing medicines (e.g. over-the-counter cold medicines) within 5 days before each test period. Caffeine, alcohol or strenuous exercise within 24 h before each test period. Current smokers.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike