Chemotherapy and Radiation Therapy With or Without Fluorouracil in Treating Patients With Cancer of the Stomach Who Have Undergone Surgery
Esophageal Cancer, Gastric Cancer
About this trial
This is an interventional treatment trial for Esophageal Cancer focused on measuring stage I gastric cancer, stage II gastric cancer, stage III gastric cancer, stage I esophageal cancer, stage II esophageal cancer, stage III esophageal cancer, adenocarcinoma of the stomach, adenocarcinoma of the esophagus
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage IB-IIIB adenocarcinoma of the stomach or gastroesophageal junction having undergone potentially curative resection of primary tumor No more than 8 weeks since primary tumor resection No metastatic disease PATIENT CHARACTERISTICS: Age: Not specified Performance status: Zubrod 0-1 Life expectancy: Not specified Hematopoietic: WBC (white blood cell count) at least 4,000/mm^3 Platelet count at least 150,000/mm^3 Hepatic: Bilirubin no greater than 1.5 mg/dL AST (aspartate aminotransferase) and ALT (alanine amino transferase) no greater than 2.5 times upper limit of normal Renal: BUN(blood urea nitrogen)less than 30 mg/dL Creatinine no greater than 1.4 mg/dL Creatinine clearance greater than 50 mL/min Cardiovascular: No New York Heart Association class III or IV heart disease No active angina or myocardial infarction within the past 6 months No history of significant ventricular arrhythmia requiring medication with antiarrhythmics No history of clinically significant conduction system abnormality Other: No concurrent serious infection that is uncontrolled or would preclude study participation No nonmalignant medical illness that is uncontrolled or would preclude study participation No psychiatric disorders that would preclude study participation No other active malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the cervix No clinically significant hearing loss Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy No other concurrent chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to the treatment field Surgery: See Disease Characteristics Other: No other concurrent anticancer therapy
Sites / Locations
- University of Alabama at Birmingham Comprehensive Cancer Center
- Mobile Infirmary Medical Center
- Providence Alaska Medical Center
- Foundation for Cancer Research and Education
- Providence Saint Joseph Medical Center - Burbank
- City of Hope Comprehensive Cancer Center
- Sutter Health Western Division Cancer Research Group
- Loma Linda University Cancer Institute at Loma Linda University Medical Center
- CCOP - Bay Area Tumor Institute
- University of California Davis Cancer Center
- CCOP - Santa Rosa Memorial Hospital
- Memorial Hospital Cancer Center
- University of Colorado Cancer Center at University of Colorado Health Sciences Center
- Yale Comprehensive Cancer Center
- Baptist Hospital of Miami
- Alexian Brothers Cancer Care Center
- Wendt Regional Cancer Center of Finley Hospital
- Cancer Center at Lexington Clinic
- Cancer Research Center at Boston Medical Center
- CCOP - Metro-Minnesota
- CCOP - Kansas City
- Siteman Cancer Center
- Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha
- John F. Kennedy Medical Center
- Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital
- Community Medical Center
- New York Methodist Hospital
- Highland Hospital of Rochester
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
- Wayne Memorial Hospital, Inc.
- Rutherford Hospital
- Akron General Medical Center
- Akron City Hospital - Summa Health System
- Ireland Cancer Center
- CCOP - Dayton
- Blanchard Valley Medical Associates
- Lima Memorial Hospital
- St. Charles Hospital
- Cancer Care Center, Incorporated
- Firelands Regional Medical Center
- Flower Hospital - ProMedica Health System
- Medical College of Ohio Cancer Institute
- CCOP - Toledo Community Hospital
- Fulton County Health Center
- Natalie Warren Bryant Cancer Center
- John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital
- Bryn Mawr Hospital
- Mercy Fitzgerald Hospital
- Delaware County Memorial Hospital
- Pocono Cancer Center
- Paoli Memorial Hospital
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Western Pennsylvania Hospital
- Lankenau Cancer Center at Lankenau Hospital
- CCOP - Upstate Carolina
- University of Texas - MD Anderson Cancer Center
- Cottonwood Hospital Medical Center
- McKay-Dee Hospital Center
- Dixie Regional Medical Center
- University of Utah Health Sciences Center
- LDS Hospital
- University of Washington Medical Center
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
- St. Vincent Hospital
- CCOP - Marshfield Clinic Research Foundation
- Columbia Hospital
- St. Luke's Medical Center
- Medical College of Wisconsin Cancer Center