Resperine, Gabapentin, or Lamotrigine for the Treatment of Cocaine Dependence: 2 - 7

Inclusion Criteria: Males and females, 18 to 59 years of age. DSM-IV diagnosis of cocaine dependence as determine by a semi-structured clinical interview. Subjects must have at least two cocaine-positive urines (BE level >300 ng/ml) during the two week screening phase of the study. Subjects must have a self reported use of at least $100 worth of cocaine within the past 30 days. Ability to provide written informed consent and to comply with all study procedures. Women of child-bearing capacity must be using one of the following acceptable methods of birth-control: a. oral contraceptives, b. barrier (diaphragm or condom) with spermicide, c. intrauterine progesterone contraceptive system, d. levonorgestrel implant, e. medroxyprogesterone acetate contraceptive injection Exclusion Criteria: Current dependence on any psychoactive substance other than cocaine, alcohol, or nicotine, physiological dependence on alcohol requiring medical detoxification. Subjects requiring treatment for neurological or psychiatric disorders. Subjects with any potentially life threatening or progressive medical illness other than addiction. Subjects with a history of hypertension currently requiring treatment. Subjects who have received a drug with known potential for toxicity to a major organ system within the month prior to entering treatment or who have been on any experimental medication within the past 60 days. Females who are pregnant or lactating or having had three or more days of amenorrhea beyond the time of expected menses at the time of the first dose of study medication. Subjects who have clinically significant abnormal laboratory values as determined by the principal investigator. Subjects who have any disease of the gastrointestinal system, liver, or kidneys which could result in altered metabolism or excretion of the study medication. Chronic therapy with any medication which could interact adversely with one of the medications under study. Therapy with any of the opiate-substitutes (methadone, LAAM, buprenorphine) within 60 days of enrollment in this study. Subjects with a seizure disorder or with a history of a seizure disorder other than childhood febrile seizures or alcohol withdrawal seizures. Subjects with a history of major depression. Patients with a history of rashes or other sensitivity reactions to reserpine, lamotrigine, or gabapentin. Participant plans to receive psychosocial treatment external to that designated in the protocol during study participation. Subjects with systolic blood pressure below 100 mm of Hg., or diastolic blood pressure below 60 mm of Hg., who are symptomatic as determined by the physician conducting the screening medical history and phy