Diagnostic Evaluation of Patients With Neuromuscular Disease

INCLUSION CRITERIA: Research patients will be studied under this protocol if they fulfill the following criteria: Have an identifiable neuromuscular disorder that may be suitable for a specific current or future protocol; Present a diagnostic puzzle in spite of the previously performed diagnostic work-up; Have unusual manifestation of a more usual neuromuscular disease; Have a disorder useful for teaching purposes. Patients should be referred by a physician who will continue their care after our evaluation. A report of the patients' visit and tests, along with suggestions or recommendations will be sent to each referring physician. There is a wide spectrum of neuromuscular diseases to be studied, among them are: peripheral neuropathies, myopathies, dystrophies, myasthenia, stiff person syndrome, muscle cramps, myotonias, motor neuron diseases, post-polio syndrome, and certain demyelinating disorders affecting both the central and the peripheral nervous system.