Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat Abnormalities

Inclusion Criteria Patients may be eligible for this study if they: Are HIV-positive. Have a viral load (level of HIV in the blood) below 10,000 copies/ml, within 30 days before study entry. Have a fasting blood insulin level at 15 micro IU/ml or greater; or a 2-hour insulin at least 75 micro IU/ml or greater following 75 g glucose load; or a 2-hour glucose greater than 140 mg/dl following 75 g glucose load AND fasting serum insulin at least 10 micro IU/ml or greater, within 30 days before study entry. Meet physical restrictions based on the amount and location of body fat and also on height and weight. Have noticed changes in the location of their body fat during the course of their HIV disease. Are 18 to 65 years old. Have taken the same anti-HIV drugs for at least 60 days before study entry and do not plan to change these drugs for the entire study. If taking hormones, have been on the same treatment for at least 6 months before study entry and do not plan to change for the entire study. Hormones include birth control pills, estrogen, or progestin for women and testosterone for men. If hormones were taken and then stopped, the treatment must have ended at least 6 months before the patient enters the study. Have a negative pregnancy test within 30 days before taking the study drugs, if female and able to have children. Agree to avoid trying to become pregnant or causing someone to become pregnant. Agree not to donate sperm or participate in other fertilization procedures. If sexually active, agree to use [AS PER AMENDMENT 02/05/02: 1] effective method of birth control while taking the study medications and for at least 30 days after stopping the study medications. Women who are not able to give birth or whose male partner is sterile are not required to use birth control. Several changes have been made to this study. In earlier versions, a fasting blood insulin above 15 micro IU/ml was the only level accepted. Now there are several other insulin/glucose levels included. In addition, the timing of pregnancy tests has changed from 14 days to 30 days. Exclusion Criteria Patients will not be eligible for this study if they: Are allergic to metformin or rosiglitazone. Are pregnant or breast-feeding. Abuse drugs or alcohol. Have diarrhea, nausea, or vomiting. Have heart disease. Are taking or have taken drugs to control blood sugar. Have taken any of the following drugs within 6 months before study entry: high-dose estrogen, high-dose testosterone, high-dose testosterone gel, testosterone creams, growth hormone, steroids to increase body size, DHEA or androstenedione (sold over the counter), prednisone and other steroid drugs at high doses, drugs to increase appetite, experimental drugs to increase appetite or weight gain, drugs that affect the immune system, pentoxifylline, thalidomide, niacin (a multivitamin containing niacin is okay), hydroxyurea, and cimetidine. Are taking ritonavir with simvastatin or lovastatin (drugs to lower cholesterol). Are taking drugs not approved by the FDA or of unknown identity, in experimental studies.