Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas
Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer
About this trial
This is an interventional treatment trial for Colorectal Cancer focused on measuring stage IV adult Hodgkin lymphoma, recurrent adult Hodgkin lymphoma, stage IV cutaneous T-cell non-Hodgkin lymphoma, recurrent cutaneous T-cell non-Hodgkin lymphoma, small intestine lymphoma, unspecified adult solid tumor, protocol specific, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, stage IV adult diffuse small cleaved cell lymphoma, stage IV adult diffuse mixed cell lymphoma, stage IV adult diffuse large cell lymphoma, stage IV adult immunoblastic large cell lymphoma, stage IV adult lymphoblastic lymphoma, stage IV adult Burkitt lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, recurrent adult diffuse small cleaved cell lymphoma, recurrent adult diffuse mixed cell lymphoma, recurrent adult diffuse large cell lymphoma, recurrent adult immunoblastic large cell lymphoma, recurrent adult lymphoblastic lymphoma, recurrent adult Burkitt lymphoma, stage IV adult T-cell leukemia/lymphoma, recurrent adult T-cell leukemia/lymphoma, stage IV mantle cell lymphoma, recurrent mantle cell lymphoma, anaplastic large cell lymphoma, stage IV mycosis fungoides/Sezary syndrome, recurrent mycosis fungoides/Sezary syndrome, recurrent adult primary liver cancer, advanced adult primary liver cancer, adult primary cholangiocellular carcinoma, stage IV non-small cell lung cancer, recurrent non-small cell lung cancer, extensive stage small cell lung cancer, recurrent small cell lung cancer, recurrent pancreatic cancer, stage IV esophageal cancer, recurrent esophageal cancer, recurrent colon cancer, stage IV colon cancer, recurrent gallbladder cancer, unresectable gallbladder cancer, cholangiocarcinoma of the gallbladder, unresectable extrahepatic bile duct cancer, recurrent extrahepatic bile duct cancer, cholangiocarcinoma of the extrahepatic bile duct, recurrent marginal zone lymphoma, recurrent small lymphocytic lymphoma, stage IV small lymphocytic lymphoma, stage IV marginal zone lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, nodal marginal zone B-cell lymphoma, splenic marginal zone lymphoma, stage IV pancreatic cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of cancer that has failed standard therapy or for which no such therapy exists, including, but not limited to: Unresectable primary or recurrent solid tumors (e.g., colon, pancreatic, lung, esophageal, or cholangiocarcinoma) Metastatic disease Lymphoma with no prior high-dose chemotherapy requiring autologous or allogeneic stem cell rescue No leukemias No CNS metastases or primary CNS malignancies No failure on prior gemcitabine therapy PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: Absolute granulocyte count at least 2,000/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin no greater than 2.0 mg/dL Transaminases less than 6 times upper limit of normal Renal: Creatinine no greater than 2.0 mg/dL Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No other serious concurrent medical illness that would preclude study No active infections requiring IV antibiotics HIV negative PRIOR CONCURRENT THERAPY: Biologic therapy: See Disease Characteristics More than 4 weeks since prior immunotherapy and recovered Chemotherapy: See Disease Characteristics More than 4 weeks since prior chemotherapy (at least 6 weeks for mitomycin or nitrosoureas) and recovered At least 3 months since prior suramin At least 5 weeks since prior eniluracil (8 weeks prior to start of fluorouracil) and recovered Endocrine therapy: No steroid therapy if utilized for chronic lymphoma therapy At least 4 weeks since prior steroidal therapy as disease treatment Radiotherapy: At least 2 weeks since prior radiotherapy to no more than 20% of bone marrow At least 4 weeks since prior radiotherapy to 21% or more of bone marrow Recovered from prior radiotherapy Surgery: Recovered from prior surgery Other: No concurrent cimetidine
Sites / Locations
- Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support