Vaccine Therapy in Treating Patients With Stage III Non-Small Cell Lung Cancer
Lung Cancer

About this trial
This is an interventional treatment trial for Lung Cancer focused on measuring stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed stage IIIA or IIIB non-small cell lung cancer (NSCLC) with one of the following p53 mutations: Point mutation altering the protein sequence Frame-shift mutation with the generation of a novel sequence No significant pleural effusions visible on plain chest radiography Must have completed or plan to undergo curative intent therapy for NSCLC At least 2 courses of neoadjuvant chemotherapy for patients with known N2 or N3 resectable disease OR At least 55 Gy radiotherapy with concurrent or sequential chemotherapy for patients with unresectable disease Patients with incidental N2 or N3 disease at time of surgery may receive optional adjuvant chemotherapy and radiotherapy PATIENT CHARACTERISTICS: Age: Not specified Performance status: ECOG 0-1 Life expectancy: Not specified Hematopoietic: Lymphocyte count greater than 475/mm^3 Granulocyte count greater than 1,000/mm^3 Platelet count greater than 100,000/mm^3 Hepatic: Bilirubin less than 2.0 mg/dL SGOT less than 3 times normal Albumin at least 3.0 g/dL No signs of acute hepatitis B infection Hepatitis B surface antigen positive allowed provided there are no signs of chronic active hepatitis No prior hepatitis C infection Renal: Creatinine less than 2.5 mg/dL Calcium less than 11.0 mg/dL (corrected for albumin) Cardiovascular: No myocardial infarction or significant ventricular arrhythmias within the past 6 months Other: No other malignancy within the past 5 years unless curatively treated and probability of recurrence is less than 5% HIV negative No psychiatric or other condition that would preclude study No serious ongoing infection No other serious medical condition that would limit life expectancy to less than 2 years Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics At least 4 weeks since prior chemotherapy and no anticipated need for chemotherapy for at least 2 months after vaccinations Endocrine therapy: At least 4 weeks since prior supraphysiologic steroids and no anticipated need for steroid therapy for at least 2 months after vaccinations Radiotherapy: See Disease Characteristics At least 4 weeks since prior radiotherapy and no anticipated need for radiotherapy for at least 2 months after vaccinations Surgery: See Disease Characteristics Other: No influenza vaccination if egg allergy present At least 4 weeks and no greater than 24 weeks since completion of all prior modalities for primary therapy
Sites / Locations
- Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
- Vanderbilt-Ingram Cancer Center