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Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

Primary Purpose

Sarcoma

Status
Unknown status
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
dactinomycin
busulfan
doxorubicin hydrochloride
etoposide
ifosfamide
melphalan
vincristine sulfate
autologous hematopoietic stem cell transplantation
conventional surgery
radiation therapy
Sponsored by
University of Leicester
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Sarcoma focused on measuring localized Ewing sarcoma/peripheral primitive neuroectodermal tumor, metastatic Ewing sarcoma/peripheral primitive neuroectodermal tumor

Eligibility Criteria

undefined - 49 Years (Child, Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Histologically confirmed tumor of the Ewing's family of bone or soft tissue Ewing's sarcoma Peripheral primitive neuroectodermal tumor Disease meeting one of the following criteria: Resectable localized disease (tumor volume less than 200 mL) Localized disease previously resected at diagnosis Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local control can be delayed Localized disease with early radiotherapy required Pulmonary and/or pleural metastases only Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes) No more than 45 days since definitive biopsy PATIENT CHARACTERISTICS: Age: Under 50 Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Renal function normal Glomerular filtration rate at least 60 mL/min Cardiovascular: Normal cardiac function Fractional shortening at least 29% Ejection fraction at least 40% Other: No medical, psychiatric, or social condition that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: See Disease Characteristics

Sites / Locations

  • UAB Comprehensive Cancer CenterRecruiting
  • Phoenix Children's HospitalRecruiting
  • Arkansas Cancer Research Center at University of Arkansas for Medical SciencesRecruiting
  • City of Hope Comprehensive Cancer CenterRecruiting
  • Childrens Hospital Los AngelesRecruiting
  • Southern California Permanente Medical GroupRecruiting
  • Lucile Packard Children's Hospital at Stanford University Medical CenterRecruiting
  • Kaiser Permanente Medical Center - OaklandRecruiting
  • Rady Children's Hospital - San DiegoRecruiting
  • UCSF Helen Diller Family Comprehensive Cancer CenterRecruiting
  • Children's Hospital Colorado Center for Cancer and Blood DisordersRecruiting
  • Alfred I. duPont Hospital for ChildrenRecruiting
  • Children's National Medical CenterRecruiting
  • Nemours Children's ClinicRecruiting
  • University of Miami Sylvester Comprehensive Cancer Center - MiamiRecruiting
  • Nemours Children's Clinic - OrlandoRecruiting
  • Nemours Children's Clinic - PensacolaRecruiting
  • All Children's HospitalRecruiting
  • St. Joseph's Cancer Institute at St. Joseph's HospitalRecruiting
  • Kaplan Cancer Center at St. Mary's Medical CenterRecruiting
  • AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston CampusRecruiting
  • Cancer Research Center of HawaiiRecruiting
  • Mountain States Tumor Institute at St. Luke's Regional Medical CenterRecruiting
  • University of Chicago Cancer Research CenterRecruiting
  • Saint Jude Midwest AffiliateRecruiting
  • Simmons Cooper Cancer InstituteRecruiting
  • Holden Comprehensive Cancer Center at University of IowaRecruiting
  • Kosair Children's HospitalRecruiting
  • Children's Hospital of New OrleansRecruiting
  • Alvin and Lois Lapidus Cancer Institute at Sinai HospitalRecruiting
  • Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer InstituteRecruiting
  • Hurley Medical CenterRecruiting
  • Helen DeVos Children's Hospital at Spectrum HealthRecruiting
  • Van Elslander Cancer Center at St. John Hospital and Medical CenterRecruiting
  • Bronson Methodist HospitalRecruiting
  • Breslin Cancer Center at Ingham Regional Medical CenterRecruiting
  • CCOP - DuluthRecruiting
  • Children's Hospitals and Clinics of Minnesota - MinneapolisRecruiting
  • Masonic Cancer Center at University of MinnesotaRecruiting
  • Mayo Clinic Cancer CenterRecruiting
  • Children's Hospitals and Clinics of Minnesota - St. PaulRecruiting
  • University of Mississippi Cancer ClinicRecruiting
  • Children's Mercy HospitalRecruiting
  • Siteman Cancer Center at Barnes-Jewish Hospital - Saint LouisRecruiting
  • CCOP - Nevada Cancer Research FoundationRecruiting
  • Hackensack University Medical Center Cancer CenterRecruiting
  • Albert Einstein Cancer Center at Albert Einstein College of MedicineRecruiting
  • Roswell Park Cancer InstituteRecruiting
  • Herbert Irving Comprehensive Cancer Center at Columbia University Medical CenterRecruiting
  • James P. Wilmot Cancer Center at University of Rochester Medical CenterRecruiting
  • SUNY Upstate Medical University HospitalRecruiting
  • Blumenthal Cancer Center at Carolinas Medical CenterRecruiting
  • Presbyterian Cancer Center at Presbyterian HospitalRecruiting
  • Duke Cancer InstituteRecruiting
  • Leo W. Jenkins Cancer Center at ECU Medical SchoolRecruiting
  • Cincinnati Children's Hospital Medical CenterRecruiting
  • Rainbow Babies and Children's HospitalRecruiting
  • Cleveland Clinic Taussig Cancer CenterRecruiting
  • Nationwide Children's HospitalRecruiting
  • Dayton Children's - DaytonRecruiting
  • Toledo HospitalRecruiting
  • Tod Children's HospitalRecruiting
  • Oklahoma University Cancer InstituteRecruiting
  • Legacy Emanuel Children's HospitalRecruiting
  • Lehigh Valley Hospital - MuhlenbergRecruiting
  • Penn State Children's HospitalRecruiting
  • Children's Hospital of PhiladelphiaRecruiting
  • Children's Hospital of Pittsburgh of UPMCRecruiting
  • Greenville Hospital Cancer CenterRecruiting
  • Avera Cancer InstituteRecruiting
  • East Tennessee Children's HospitalRecruiting
  • Texas Tech University Health Sciences Center School of Medicine - AmarilloRecruiting
  • Driscoll Children's HospitalRecruiting
  • Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - DallasRecruiting
  • Cook Children's Medical Center - Fort WorthRecruiting
  • University of Texas Health Science Center at San AntonioRecruiting
  • Methodist Children's Hospital of South TexasRecruiting
  • Primary Children's Medical CenterRecruiting
  • University of Virginia Cancer CenterRecruiting
  • Inova Fairfax HospitalRecruiting
  • Children's Hospital of The King's DaughtersRecruiting
  • Children's Hospital and Regional Medical Center - SeattleRecruiting
  • Providence Cancer Center at Sacred Heart Medical CenterRecruiting
  • Mary Bridge Children's Hospital and Health Center - TacomaRecruiting
  • West Virginia University Health Sciences Center - CharlestonRecruiting
  • St. Vincent Hospital Regional Cancer CenterRecruiting
  • Marshfield Clinic - Marshfield CenterRecruiting
  • Midwest Children's Cancer Center at Children's Hospital of WisconsinRecruiting
  • Children's Hospital at WestmeadRecruiting
  • Royal Children's HospitalRecruiting
  • Women's and Children's HospitalRecruiting
  • Princess Margaret Hospital for ChildrenRecruiting
  • University of Alberta HospitalRecruiting
  • Children's and Women's Hospital of British ColumbiaRecruiting
  • CancerCare ManitobaRecruiting
  • Janeway Children's Health and Rehabilitation CentreRecruiting
  • IWK Health CentreRecruiting
  • Hospital for Sick ChildrenRecruiting
  • Hopital Sainte JustineRecruiting
  • Saskatoon Cancer Centre at the University of SaskatchewanRecruiting
  • Centre Hospitalier Universitaire de QuebecRecruiting
  • Starship Children's HealthRecruiting
  • San Jorge Children's HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Experimental

Arm Label

Group 1

Group 2, arm I

Group 2, arm II

Arm Description

Patients receive 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Patients requiring radiotherapy to the axial tumor also undergo concurrent radiotherapy 5 days a week. Some patients may then undergo surgical resection of the tumor. All patients will then receive vincristine IV on day 1 and dactinomycin IV and ifosfamide IV over 3 hours on days 1 and 2 (VAI). Treatment repeats every 21 days for 8 courses (courses 7-14). Patients requiring radiotherapy to the brain and/or spinal cord also undergo concurrent radiotherapy.

Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients then receive 7 additional courses of VAI chemotherapy (courses 8-14). Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent whole-lung radiotherapy for 6-12 days.

Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients then receive high-dose chemotherapy comprising oral busulfan every 6 hours on days -6 to -3 and melphalan IV over 30 minutes on day -2. Patients receive autologous PBSC IV on day 0. Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent radiotherapy 5 days a week for at least 5 weeks.

Outcomes

Primary Outcome Measures

Event-free survival
Overall survival

Secondary Outcome Measures

Feasibility, toxicity, and response at 1 month following induction therapy
Feasibility and toxicity of consolidation regimens at 1 month following consolidation therapy

Full Information

First Posted
July 11, 2001
Last Updated
June 23, 2014
Sponsor
University of Leicester
Collaborators
National Cancer Institute (NCI), Children's Cancer and Leukaemia Group, Societe Francaise Oncologie Pediatrique, European Organisation for Research and Treatment of Cancer - EORTC, German Society for Pediatric Oncology and Hematology GPOH gGmbH, Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria, Swiss Group for Clinical Cancer Research, EBMT Solid Tumors Working Party, Children's Oncology Group
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1. Study Identification

Unique Protocol Identification Number
NCT00020566
Brief Title
Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma
Official Title
European Ewing Tumour Working Initiative of National Groups Ewing Tumour Studies 1999 (EURO-E.W.I.N.G.99)
Study Type
Interventional

2. Study Status

Record Verification Date
June 2012
Overall Recruitment Status
Unknown status
Study Start Date
February 2001 (undefined)
Primary Completion Date
December 2011 (Anticipated)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
University of Leicester
Collaborators
National Cancer Institute (NCI), Children's Cancer and Leukaemia Group, Societe Francaise Oncologie Pediatrique, European Organisation for Research and Treatment of Cancer - EORTC, German Society for Pediatric Oncology and Hematology GPOH gGmbH, Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria, Swiss Group for Clinical Cancer Research, EBMT Solid Tumors Working Party, Children's Oncology Group

4. Oversight

5. Study Description

Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more tumor cells. It is not yet known if combination chemotherapy is more effective with or without radiation therapy and/or surgery in treating Ewing's sarcoma. PURPOSE: This randomized phase III trial is studying different combination chemotherapy regimens to see how well they work when given with or without peripheral stem cell transplantation, radiation therapy, and/or surgery in treating patients with Ewing's sarcoma.
Detailed Description
OBJECTIVES: Primary Compare the event-free and overall survival of patients with tumor of the Ewing's family treated with standard induction chemotherapy comprising vincristine, dactinomycin, ifosfamide and etoposide (VIDE) followed by consolidation chemotherapy comprising vincristine, dactinomycin, and ifosfamide versus high-dose busulfan and melphalan (Bu-Mel) followed by autologous peripheral blood stem cell (PBSC) transplantation with or without radiotherapy and/or surgery. Secondary Determine the prognostic significance of EWS-Flil transcript in these patients. Determine the frequency and prognostic value of minimal disease in bone marrow and PBSC, as determined by the presence or absence of EWS-Flil transcript, in these patients. Determine the feasibility and toxicity of VIDE induction chemotherapy in these patients. Determine the response of these patients to VIDE induction chemotherapy. Determine the feasibility and toxicity of VAI consolodation chemotherapy in these patients. Determine the feasibility and toxicity of Bu-Mel consolodation chemotherapy in these patients. Determine event-free survival and overall survival of patients treated with these regimens by prognostic group analysis. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to age and local treatment of the primary tumor (yes vs no). Patients receive induction chemotherapy comprising vincristine IV on day 1 and ifosfamide IV over 3 hours, doxorubicin IV over 4 hours, and etoposide IV over 1 hour on days 1-3 (VIDE). Treatment repeats every 21 days for 4 courses in the absence of unacceptable toxicity. Peripheral blood stem cells (PBSC) are collected after course 3 and/or 4. Patients are evaluated after course 4. Patients in need of early radiotherapy due to an axial tumor or patients who require radiotherapy to the brain and/or spinal cord (at any time during study) are assigned to group 1. Patients not needing early radiotherapy are assigned to group 2. Group 1: Patients receive 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Patients requiring radiotherapy to the axial tumor also undergo concurrent radiotherapy 5 days a week. Some patients may then undergo surgical resection of the tumor. All patients will then receive vincristine IV on day 1 and dactinomycin IV and ifosfamide IV over 3 hours on days 1 and 2 (VAI). Treatment repeats every 21 days for 8 courses (courses 7-14). Patients requiring radiotherapy to the brain and/or spinal cord also undergo concurrent radiotherapy. Group 2: Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients are randomized to 1 of 2 consolidation therapy arms. Arm I: Patients receive 7 additional courses of VAI chemotherapy (courses 8-14). Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent whole-lung radiotherapy for 6-12 days. Arm II: Patients receive high-dose chemotherapy comprising oral busulfan every 6 hours on days -6 to -3 and melphalan IV over 30 minutes on day -2. Patients receive autologous PBSC IV on day 0. Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent radiotherapy 5 days a week for at least 5 weeks. Patients are followed every 3 months for 4 years, every 6 months for 1 year, and then periodically thereafter. Peer Reviewed and Funded or Endorsed by Cancer Research UK PROJECTED ACCRUAL: Approximately 1,200 patients will be accrued for this study within approximately 7 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sarcoma
Keywords
localized Ewing sarcoma/peripheral primitive neuroectodermal tumor, metastatic Ewing sarcoma/peripheral primitive neuroectodermal tumor

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Allocation
Randomized
Enrollment
1200 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Group 1
Arm Type
Experimental
Arm Description
Patients receive 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Patients requiring radiotherapy to the axial tumor also undergo concurrent radiotherapy 5 days a week. Some patients may then undergo surgical resection of the tumor. All patients will then receive vincristine IV on day 1 and dactinomycin IV and ifosfamide IV over 3 hours on days 1 and 2 (VAI). Treatment repeats every 21 days for 8 courses (courses 7-14). Patients requiring radiotherapy to the brain and/or spinal cord also undergo concurrent radiotherapy.
Arm Title
Group 2, arm I
Arm Type
Experimental
Arm Description
Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients then receive 7 additional courses of VAI chemotherapy (courses 8-14). Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent whole-lung radiotherapy for 6-12 days.
Arm Title
Group 2, arm II
Arm Type
Experimental
Arm Description
Patients undergo 2 additional courses of VIDE induction chemotherapy (courses 5 and 6). Some patients may then undergo surgical resection of the tumor. All patients receive VAI chemotherapy as in group 1 for 1 course. Patients then receive high-dose chemotherapy comprising oral busulfan every 6 hours on days -6 to -3 and melphalan IV over 30 minutes on day -2. Patients receive autologous PBSC IV on day 0. Patients with unresectable, partially resected, or inadequately resected disease undergo concurrent radiotherapy 5 days a week for at least 5 weeks.
Intervention Type
Biological
Intervention Name(s)
dactinomycin
Intervention Description
Given IV
Intervention Type
Drug
Intervention Name(s)
busulfan
Intervention Description
Given orally and IV
Intervention Type
Drug
Intervention Name(s)
doxorubicin hydrochloride
Intervention Description
Given IV
Intervention Type
Drug
Intervention Name(s)
etoposide
Intervention Description
Given IV
Intervention Type
Drug
Intervention Name(s)
ifosfamide
Intervention Description
Given IV
Intervention Type
Drug
Intervention Name(s)
melphalan
Intervention Description
Given orally and IV
Intervention Type
Drug
Intervention Name(s)
vincristine sulfate
Intervention Description
Given IV
Intervention Type
Procedure
Intervention Name(s)
autologous hematopoietic stem cell transplantation
Intervention Description
Given IV
Intervention Type
Procedure
Intervention Name(s)
conventional surgery
Intervention Description
Given to patients deemed to require it
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Intervention Description
Given to patients deemed to require it
Primary Outcome Measure Information:
Title
Event-free survival
Title
Overall survival
Secondary Outcome Measure Information:
Title
Feasibility, toxicity, and response at 1 month following induction therapy
Title
Feasibility and toxicity of consolidation regimens at 1 month following consolidation therapy

10. Eligibility

Sex
All
Maximum Age & Unit of Time
49 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed tumor of the Ewing's family of bone or soft tissue Ewing's sarcoma Peripheral primitive neuroectodermal tumor Disease meeting one of the following criteria: Resectable localized disease (tumor volume less than 200 mL) Localized disease previously resected at diagnosis Unresectable disease (at least 200 mL tumor volume) but radiotherapy as local control can be delayed Localized disease with early radiotherapy required Pulmonary and/or pleural metastases only Extrapulmonary/pleural metastases (skeleton, bone marrow, lymph nodes) No more than 45 days since definitive biopsy PATIENT CHARACTERISTICS: Age: Under 50 Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Renal function normal Glomerular filtration rate at least 60 mL/min Cardiovascular: Normal cardiac function Fractional shortening at least 29% Ejection fraction at least 40% Other: No medical, psychiatric, or social condition that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: See Disease Characteristics
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Alan W. Craft, MD
Organizational Affiliation
Sir James Spence Institute of Child Health at Royal Victoria Infirmary
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Ian J. Lewis, MD
Organizational Affiliation
Leeds Cancer Centre at St. James's University Hospital
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Odile Oberlin, MD
Organizational Affiliation
Gustave Roussy, Cancer Campus, Grand Paris
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Ian R. Judson, MA, MD, FRCP
Organizational Affiliation
Institute of Cancer Research, United Kingdom
First Name & Middle Initial & Last Name & Degree
Heribert F. Juergens, MD
Organizational Affiliation
University Hospital Muenster
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Helmut Gadner, MD, FRCPG
Organizational Affiliation
St. Anna Kinderkrebsforschung
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
G. Ulrich Exner, MD
Organizational Affiliation
Balgrist Universitaetsklinik
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Ruth Ladenstein, MD
Organizational Affiliation
St. Anna Kinderkrebsforschung
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Douglas Hawkins, MD
Organizational Affiliation
Seattle Children's Hospital
Official's Role
Study Chair
Facility Information:
Facility Name
UAB Comprehensive Cancer Center
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - UAB Comprehensive Cancer Center
Phone
205-934-0309
Facility Name
Phoenix Children's Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85016-7710
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jessica Boklan
Phone
602-546-0920
Facility Name
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trial Office - Arkansas Cancer Research Center at Uni
Phone
501-686-8274
Facility Name
City of Hope Comprehensive Cancer Center
City
Duarte
State/Province
California
ZIP/Postal Code
91010-3000
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - City of Hope Comprehensive Cancer Cen
Phone
800-826-4673
Email
becomingapatient@coh.org
Facility Name
Childrens Hospital Los Angeles
City
Los Angeles
State/Province
California
ZIP/Postal Code
90027
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Leo Mascarenhas
Phone
323-361-2529
Facility Name
Southern California Permanente Medical Group
City
Los Angeles
State/Province
California
ZIP/Postal Code
90027
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert M. Cooper
Phone
323-783-5307
Facility Name
Lucile Packard Children's Hospital at Stanford University Medical Center
City
Palo Alto
State/Province
California
ZIP/Postal Code
95798
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Neyssa M. Marina
Phone
650-723-5535
Facility Name
Kaiser Permanente Medical Center - Oakland
City
Sacramento
State/Province
California
ZIP/Postal Code
95661
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Vincent A. Kiley
Phone
916-474-2326
Facility Name
Rady Children's Hospital - San Diego
City
San Diego
State/Province
California
ZIP/Postal Code
92123-4282
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Rady Children's Hospital - San Diego
Phone
858-966-5934
Facility Name
UCSF Helen Diller Family Comprehensive Cancer Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - UCSF Helen Diller Family Comprehensi
Phone
877-827-3222
Facility Name
Children's Hospital Colorado Center for Cancer and Blood Disorders
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kelly W. Maloney
Phone
720-777-6673
Facility Name
Alfred I. duPont Hospital for Children
City
Wilmington
State/Province
Delaware
ZIP/Postal Code
19803
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Alfred I. duPont Hospital for Childre
Phone
302-651-5755
Facility Name
Children's National Medical Center
City
Washington
State/Province
District of Columbia
ZIP/Postal Code
20010-2970
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Children's National Medical Center
Phone
202-884-2549
Facility Name
Nemours Children's Clinic
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eric S. Sandler
Phone
904-697-3793
Facility Name
University of Miami Sylvester Comprehensive Cancer Center - Miami
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
University of Miami Sylvester Comprehensive Cancer Center Clin
Phone
866-574-5124
Email
Sylvester@emergingmed.com
Facility Name
Nemours Children's Clinic - Orlando
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ramamoorthy Nagasubramanian
Phone
407-650-7230
Facility Name
Nemours Children's Clinic - Pensacola
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32504
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeffrey H. Schwartz
Phone
850-505-4790
Facility Name
All Children's Hospital
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33701
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gregory A. Hale
Phone
727-767-4176
Facility Name
St. Joseph's Cancer Institute at St. Joseph's Hospital
City
Tampa
State/Province
Florida
ZIP/Postal Code
33607
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - St. Joseph's Cancer Institute
Phone
800-882-4123
Facility Name
Kaplan Cancer Center at St. Mary's Medical Center
City
West Palm Beach
State/Province
Florida
ZIP/Postal Code
33407
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Narayana Gowda
Phone
561-844-6363
Facility Name
AFLAC Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta - Egleston Campus
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Todd M. Cooper
Phone
404-785-1838
Facility Name
Cancer Research Center of Hawaii
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Cancer Research Center of Hawaii
Phone
808-586-2979
Facility Name
Mountain States Tumor Institute at St. Luke's Regional Medical Center
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712-6297
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eugenia Chang
Phone
208-381-2731
Facility Name
University of Chicago Cancer Research Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637-1470
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - University of Chicago Cancer Research
Phone
773-834-7424
Facility Name
Saint Jude Midwest Affiliate
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61603
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pedro A. De Alarcon
Phone
309-655-4242
Facility Name
Simmons Cooper Cancer Institute
City
Springfield
State/Province
Illinois
ZIP/Postal Code
62794-9677
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Simmons Cooper Cancer Institute
Phone
217-545-7929
Facility Name
Holden Comprehensive Cancer Center at University of Iowa
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242-1002
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Cancer Information Service
Phone
800-237-1225
Facility Name
Kosair Children's Hospital
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40232
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Kosair Children's Hospital
Phone
502-629-5500
Email
CancerResource@nortonhealthcare.org
Facility Name
Children's Hospital of New Orleans
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70118
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Children's Hospital of New Orleans
Phone
504-894-5377
Facility Name
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21215
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Joseph M. Wiley
Phone
410-601-6266
Facility Name
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
2115
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Carlos Rodriguez-Galindo
Phone
617-632-4580
Facility Name
Hurley Medical Center
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Hurley Medical Center
Phone
810-762-8057
Facility Name
Helen DeVos Children's Hospital at Spectrum Health
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49503
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Helen DeVos Children's Hospital
Phone
616-391-3050
Facility Name
Van Elslander Cancer Center at St. John Hospital and Medical Center
City
Grosse Pointe Woods
State/Province
Michigan
ZIP/Postal Code
48236
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clincial Trials Office - Van Elslander Cancer Center at St. Jo
Phone
313-343-3166
Facility Name
Bronson Methodist Hospital
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49007-5381
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jeffrey S. Lobel
Phone
269-341-6350
Facility Name
Breslin Cancer Center at Ingham Regional Medical Center
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Breslin Cancer Center at Ingham Regio
Phone
517-334-2765
Facility Name
CCOP - Duluth
City
Duluth
State/Province
Minnesota
ZIP/Postal Code
55805-1983
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
218-786-8364
Facility Name
Children's Hospitals and Clinics of Minnesota - Minneapolis
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55404
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Children's Hospitals and Clinics of M
Phone
612-813-5193
Facility Name
Masonic Cancer Center at University of Minnesota
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55455
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Masonic Cancer Center at University o
Phone
612-624-2620
Facility Name
Mayo Clinic Cancer Center
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - All Mayo Clinic Locations
Phone
507-538-7623
Facility Name
Children's Hospitals and Clinics of Minnesota - St. Paul
City
St. Paul
State/Province
Minnesota
ZIP/Postal Code
55102-2392
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
612-220-6000
Facility Name
University of Mississippi Cancer Clinic
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216-4505
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Gail C. Megason
Phone
601-984-5220
Facility Name
Children's Mercy Hospital
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64108
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maxine L. Hetherington
Phone
816-234-3265
Facility Name
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert J. Hayashi
Phone
314-454-2041
Facility Name
CCOP - Nevada Cancer Research Foundation
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109-2306
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jonathan Bernstein
Phone
702-732-1493
Facility Name
Hackensack University Medical Center Cancer Center
City
Hackensack
State/Province
New Jersey
ZIP/Postal Code
07601
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Hackensack University Medical Center
Phone
201-996-2879
Facility Name
Albert Einstein Cancer Center at Albert Einstein College of Medicine
City
Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Albert Einstein Cancer Center at Albe
Phone
718-904-2730
Email
aecc@aecom.yu.edu
Facility Name
Roswell Park Cancer Institute
City
Buffalo
State/Province
New York
ZIP/Postal Code
14263-0001
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Roswell Park Cancer Institute
Phone
877-275-7724
Facility Name
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Herbert Irving Comprehensive Cancer C
Phone
212-305-8615
Facility Name
James P. Wilmot Cancer Center at University of Rochester Medical Center
City
Rochester
State/Province
New York
ZIP/Postal Code
14642
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lisa R. Hackney
Phone
585-275-2981
Facility Name
SUNY Upstate Medical University Hospital
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - SUNY Upstate Medical University Hospi
Phone
315-464-5476
Facility Name
Blumenthal Cancer Center at Carolinas Medical Center
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28232-2861
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Blumenthal Cancer Center at Carolinas
Phone
704-355-2884
Facility Name
Presbyterian Cancer Center at Presbyterian Hospital
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28233-3549
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Presbyterian Cancer Center at Presbyt
Phone
704-384-5369
Facility Name
Duke Cancer Institute
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Duke Cancer Institute
Phone
888-275-3853
Facility Name
Leo W. Jenkins Cancer Center at ECU Medical School
City
Greenville
State/Province
North Carolina
ZIP/Postal Code
27834
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Leo W. Jenkins Cancer Center at ECU M
Phone
252-744-2391
Facility Name
Cincinnati Children's Hospital Medical Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45229-3039
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Cincinnati Children's Hospital Medica
Phone
513-636-2799
Facility Name
Rainbow Babies and Children's Hospital
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106-5000
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yousif (Joe) H. Matloub
Phone
216-844-3345
Facility Name
Cleveland Clinic Taussig Cancer Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Cleveland Clinic Taussig Cancer Cente
Phone
866-223-8100
Facility Name
Nationwide Children's Hospital
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43205-2696
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laura T. Martin
Phone
614-722-3582
Facility Name
Dayton Children's - Dayton
City
Dayton
State/Province
Ohio
ZIP/Postal Code
45404-1815
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Emmett H. Broxson
Phone
937-641-3111
Facility Name
Toledo Hospital
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43606
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Toledo Hospital
Phone
419-824-1842
Facility Name
Tod Children's Hospital
City
Youngstown
State/Province
Ohio
ZIP/Postal Code
44501
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Tod Children's Hospital
Phone
330-884-3955
Facility Name
Oklahoma University Cancer Institute
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rene Y. McNall-Knapp
Phone
405-271-5311
Facility Name
Legacy Emanuel Children's Hospital
City
Portland
State/Province
Oregon
ZIP/Postal Code
97227
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Legacy Emanuel Children's Hospital
Phone
503-413-2560
Facility Name
Lehigh Valley Hospital - Muhlenberg
City
Bethlehem
State/Province
Pennsylvania
ZIP/Postal Code
18017
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philip M. Monteleone
Phone
484-884-3333
Facility Name
Penn State Children's Hospital
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033-0850
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
John F. Kuttesch
Phone
717-531-6012
Facility Name
Children's Hospital of Philadelphia
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elizabeth Fox
Phone
267-425-3010
Facility Name
Children's Hospital of Pittsburgh of UPMC
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Children's Hospital of Pittsburgh
Phone
412-692-7056
Facility Name
Greenville Hospital Cancer Center
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29605
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Greenville Hospital Cancer Center
Phone
864-241-6251
Facility Name
Avera Cancer Institute
City
Sioux Falls
State/Province
South Dakota
ZIP/Postal Code
57105
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Contact Person
Phone
605-322-3000
Facility Name
East Tennessee Children's Hospital
City
Knoxville
State/Province
Tennessee
ZIP/Postal Code
37916
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Ray C. Pais
Phone
865-541-8266
Facility Name
Texas Tech University Health Sciences Center School of Medicine - Amarillo
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Osvaldo Regueira
Phone
806-354-5434x282
Facility Name
Driscoll Children's Hospital
City
Corpus Christi
State/Province
Texas
ZIP/Postal Code
78411
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Driscoll Children's Hospital
Phone
361-694-5311
Facility Name
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Simmons Comprehensive Cancer Center a
Phone
866-460-4673; 214-648-7097
Facility Name
Cook Children's Medical Center - Fort Worth
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Cook's Children's Medical Center
Phone
682-885-2103
Facility Name
University of Texas Health Science Center at San Antonio
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78207
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne-Marie R. Langevin
Phone
210-567-7477
Facility Name
Methodist Children's Hospital of South Texas
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229-3993
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jaime Estrada
Phone
210-575-7268
Facility Name
Primary Children's Medical Center
City
Salt Lake City
State/Province
Utah
ZIP/Postal Code
84113-1100
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Phillip E. Barnette
Phone
801-662-4700
Facility Name
University of Virginia Cancer Center
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Kimberly P. Dunsmore
Phone
434-924-5105
Facility Name
Inova Fairfax Hospital
City
Falls Church
State/Province
Virginia
ZIP/Postal Code
22042-3300
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Inova Fairfax Hospital
Phone
703-208-6650
Facility Name
Children's Hospital of The King's Daughters
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23507-1971
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eric J. Lowe
Phone
757-668-7243
Facility Name
Children's Hospital and Regional Medical Center - Seattle
City
Seattle
State/Province
Washington
ZIP/Postal Code
98105
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Julie R. Park
Phone
206-987-2106
Facility Name
Providence Cancer Center at Sacred Heart Medical Center
City
Spokane
State/Province
Washington
ZIP/Postal Code
99220-2555
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Judy L. Felgenhauer
Phone
509-474-2777
Facility Name
Mary Bridge Children's Hospital and Health Center - Tacoma
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Robert G. Irwin
Phone
253-403-3481
Facility Name
West Virginia University Health Sciences Center - Charleston
City
Charleston
State/Province
West Virginia
ZIP/Postal Code
25302
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Allen R. Chauvenet
Phone
304-388-1552
Facility Name
St. Vincent Hospital Regional Cancer Center
City
Green Bay
State/Province
Wisconsin
ZIP/Postal Code
54307-3508
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - St. Vincent Hospital Regional Cancer
Phone
920-433-8889
Facility Name
Marshfield Clinic - Marshfield Center
City
Marshfield
State/Province
Wisconsin
ZIP/Postal Code
54449
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Clinical Trials Office - Marshfield Clinic - Marshfield Center
Phone
800-782-1581 ext. 94457
Facility Name
Midwest Children's Cancer Center at Children's Hospital of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Michael E. Kelly
Phone
414-456-4170
Facility Name
Children's Hospital at Westmead
City
Westmead
State/Province
New South Wales
ZIP/Postal Code
2145
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Geoffrey B. McCowage
Phone
61298452122
Facility Name
Royal Children's Hospital
City
Brisbane
State/Province
Queensland
ZIP/Postal Code
4029
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Helen Irving
Phone
617-3636-8671
Facility Name
Women's and Children's Hospital
City
North Adelaide
State/Province
South Australia
ZIP/Postal Code
5006
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Maria L. Kirby
Phone
61881617411
Facility Name
Princess Margaret Hospital for Children
City
Perth
State/Province
Western Australia
ZIP/Postal Code
6001
Country
Australia
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Catherine H. Cole
Phone
011-6189340-8238
Facility Name
University of Alberta Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G 2B7
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sunil Jayantilal' S. Desai
Phone
780-248-5530
Facility Name
Children's and Women's Hospital of British Columbia
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V6H 3V4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Caron Strahlendorf
Phone
604-875-3576
Facility Name
CancerCare Manitoba
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3E 0V9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Rochelle A. Yanofsky
Phone
204-787-4163
Facility Name
Janeway Children's Health and Rehabilitation Centre
City
St. John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1B 3V6
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lisa Anne B. Goodyear
Phone
709-777-4303
Facility Name
IWK Health Centre
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3J 3G9
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Margaret C. Yhap
Phone
902-470-8778
Facility Name
Hospital for Sick Children
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X8
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Sylvain Baruchel
Phone
416-813-7795
Facility Name
Hopital Sainte Justine
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1C5
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yvan Samson
Phone
514-345-4931x2790
Facility Name
Saskatoon Cancer Centre at the University of Saskatchewan
City
Saskatoon
State/Province
Saskatchewan
ZIP/Postal Code
S7N 4H4
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Christopher Mpofu
Phone
306-655-2744
Facility Name
Centre Hospitalier Universitaire de Quebec
City
Quebec
ZIP/Postal Code
G1V 4G2
Country
Canada
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bruno Michon
Phone
418-656-4141X47191
Facility Name
Starship Children's Health
City
Auckland
ZIP/Postal Code
1
Country
New Zealand
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lochie R. Teague
Phone
649-307-4949x22423
Facility Name
San Jorge Children's Hospital
City
Santurce
ZIP/Postal Code
00912
Country
Puerto Rico
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Luis A. Clavell
Phone
787-728-1575

12. IPD Sharing Statement

Citations:
PubMed Identifier
20547982
Citation
Ladenstein R, Potschger U, Le Deley MC, Whelan J, Paulussen M, Oberlin O, van den Berg H, Dirksen U, Hjorth L, Michon J, Lewis I, Craft A, Jurgens H. Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial. J Clin Oncol. 2010 Jul 10;28(20):3284-91. doi: 10.1200/JCO.2009.22.9864. Epub 2010 Jun 14.
Results Reference
result
PubMed Identifier
20308673
Citation
Le Deley MC, Delattre O, Schaefer KL, Burchill SA, Koehler G, Hogendoorn PC, Lion T, Poremba C, Marandet J, Ballet S, Pierron G, Brownhill SC, Nesslbock M, Ranft A, Dirksen U, Oberlin O, Lewis IJ, Craft AW, Jurgens H, Kovar H. Impact of EWS-ETS fusion type on disease progression in Ewing's sarcoma/peripheral primitive neuroectodermal tumor: prospective results from the cooperative Euro-E.W.I.N.G. 99 trial. J Clin Oncol. 2010 Apr 20;28(12):1982-8. doi: 10.1200/JCO.2009.23.3585. Epub 2010 Mar 22.
Results Reference
result
PubMed Identifier
16572419
Citation
Juergens C, Weston C, Lewis I, Whelan J, Paulussen M, Oberlin O, Michon J, Zoubek A, Juergens H, Craft A. Safety assessment of intensive induction with vincristine, ifosfamide, doxorubicin, and etoposide (VIDE) in the treatment of Ewing tumors in the EURO-E.W.I.N.G. 99 clinical trial. Pediatr Blood Cancer. 2006 Jul;47(1):22-9. doi: 10.1002/pbc.20820.
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Dirksen U, Brennan B, Le Deley MC, Cozic N, van den Berg H, Bhadri V, Brichard B, Claude L, Craft A, Amler S, Gaspar N, Gelderblom H, Goldsby R, Gorlick R, Grier HE, Guinbretiere JM, Hauser P, Hjorth L, Janeway K, Juergens H, Judson I, Krailo M, Kruseova J, Kuehne T, Ladenstein R, Lervat C, Lessnick SL, Lewis I, Linassier C, Marec-Berard P, Marina N, Morland B, Pacquement H, Paulussen M, Randall RL, Ranft A, Le Teuff G, Wheatley K, Whelan J, Womer R, Oberlin O, Hawkins DS; Euro-E.W.I.N.G. 99 and Ewing 2008 Investigators. High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008. J Clin Oncol. 2019 Dec 1;37(34):3192-3202. doi: 10.1200/JCO.19.00915. Epub 2019 Sep 25.
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PubMed Identifier
24982464
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Le Deley MC, Paulussen M, Lewis I, Brennan B, Ranft A, Whelan J, Le Teuff G, Michon J, Ladenstein R, Marec-Berard P, van den Berg H, Hjorth L, Wheatley K, Judson I, Juergens H, Craft A, Oberlin O, Dirksen U. Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. J Clin Oncol. 2014 Aug 10;32(23):2440-8. doi: 10.1200/JCO.2013.54.4833. Epub 2014 Jun 30.
Results Reference
derived

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Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

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