Celecoxib in Preventing Non-Small Cell Lung Cancer in Tobacco Smokers
Lung Cancer
About this trial
This is an interventional prevention trial for Lung Cancer focused on measuring non-small cell lung cancer
Eligibility Criteria
Inclusion Criteria: Age > 45 Smoked > 20 pack years Exclusion Criteria: Concurrent use of NSAIDs Hypersensitivity to celecoxib Documented allergic-type reaction to sulfonamides History of allergic reaction, urticaria or asthma to aspirin or other NSAIDs History of liver dysfunction Hypertension or cardiac conditions aggravated by fluid retention and edema Previous history of gastrointestinal ulceration, bleeding, or perforation Renal dysfunction End stage respiratory disease Unstable angina Other malignancy Pregnancy Concurrent use of medication known to alter or be affected by alteration of the hepatic p450 2C9 and 2D6 enzymes Patents with concurrent medical conditions that may interfere with completion of tests, therapy, or the follow up schedule
Sites / Locations
- Jonsson Comprehensive Cancer Center, UCLA
Arms of the Study
Arm 1
Experimental
Study
See intervention description.