Combination Chemotherapy, Surgery or Radiation Therapy, and Peripheral Stem Cell Transplant in Treating Patients With Recurrent Medulloblastoma or Primitive Neuroectodermal and Pineal Tumors
Brain and Central Nervous System Tumors
About this trial
This is an interventional treatment trial for Brain and Central Nervous System Tumors focused on measuring recurrent childhood supratentorial primitive neuroectodermal tumor, recurrent childhood medulloblastoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed recurrent medulloblastoma or supratentorial primitive neuroectodermal and pineal tumor Nodular/desmoplastic medulloblastoma Medullomyoblastoma Melanotic medulloblastoma Ependymoblastoma Pinealoblastoma Received prior craniospinal radiotherapy OR Relapse in site of prior localized radiotherapy (e.g., relapse after "baby brain" protocol) PATIENT CHARACTERISTICS: Age: Under 21 Performance status: Lansky 40-100% for ages 1-16 years Karnofsky 40-100% for ages over 16 years Life expectancy: At least 8 weeks Hematopoietic: Neutrophil count at least 1,000/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin less than upper limit of normal (ULN) AST less than 2 times ULN Renal: Glomerular filtration rate at least 60 mL/min Other: Not pregnant or nursing Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy See Disease Characteristics Surgery Not specified
Sites / Locations
- Our Lady's Hospital for Sick Children Crumlin
- Birmingham Children's Hospital
- Bristol Royal Hospital for Children
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Leeds Cancer Centre at St. James's University Hospital
- Leicester Royal Infirmary
- Royal Liverpool Children's Hospital, Alder Hey
- Saint Bartholomew's Hospital
- Great Ormond Street Hospital for Children NHS Trust
- University College of London Hospitals
- Central Manchester and Manchester Children's University Hospitals NHS Trust
- Newcastle Upon Tyne Hospitals NHS Trust
- Queen's Medical Centre
- Oxford Radcliffe Hospital
- Children's Hospital - Sheffield
- Southampton University Hospital NHS Trust
- Royal Marsden NHS Foundation Trust - Surrey
- Royal Belfast Hospital for Sick Children
- Aberdeen Royal Infirmary
- Royal Hospital for Sick Children
- Royal Hospital for Sick Children