Radiation Therapy Plus Fluorouracil With or Without Additional Chemotherapy in Treating Patients With Primary Anal Cancer
Anal Cancer
About this trial
This is an interventional treatment trial for Anal Cancer focused on measuring stage I anal cancer, stage II anal cancer, stage IIIA anal cancer, stage IIIB anal cancer, squamous cell carcinoma of the anus, cloacogenic carcinoma of the anus, basaloid carcinoma of the anus
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed primary epidermoid anal cancer Squamous cell Basaloid Cloacogenic No adenocarcinoma, malignant melanoma, mucoepidermoid carcinoma, lymphoma, or microinvasive anal intraepithelial neoplasia (without evidence of invasive disease) in the anal canal or margin No metastatic disease PATIENT CHARACTERISTICS: Age: Not specified Performance status: 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 3,000/mm^3 Platelet count greater than 100,000/mm^3 Hemoglobin greater than 10 g/dL Hepatic: Liver function tests no greater than 2 times normal Renal: Glomerular filtration rate at least 50 mL/min Cardiovascular: No cardiovascular disease No uncontrolled angina pectoris No heart failure No clinically significant cardiac arrhythmias Other: HIV negative No other significant concurrent illness Not predominately bed-bound or frail No severe sepsis No other prior or concurrent cancer or illness that would preclude study participation PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: Not specified Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy to pelvis Surgery: Not specified Other: No prior therapy for anal cancer
Sites / Locations
- Northwick Park Hospital
- Ipswich Hospital
- Cookridge Hospital
- Saint Bartholomew's Hospital
- Cancer Research UK and University College London Cancer Trials Centre
- James Cook University Hospital
- Mount Vernon Cancer Centre at Mount Vernon Hospital
- Nottingham City Hospital
- Royal Marsden - Surrey
- Southend University Hospital NHS Foundation Trust
- Aberdeen Royal Infirmary
- Velindre Cancer Center at Velindre Hospital
- Cancer Research Centre at Weston Park Hospital