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Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia

Primary Purpose

Leukemia

Status
Unknown status
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
filgrastim
recombinant interferon alfa
busulfan
cyclophosphamide
cytarabine
etoposide
hydroxyurea
idarubicin
allogeneic bone marrow transplantation
peripheral blood stem cell transplantation
radiation therapy
Sponsored by
III. Medizinische Klinik Mannheim
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an interventional treatment trial for Leukemia focused on measuring chronic phase chronic myelogenous leukemia, chronic myelogenous leukemia, BCR-ABL1 positive, Philadelphia chromosome negative chronic myelogenous leukemia, childhood chronic myelogenous leukemia, atypical chronic myeloid leukemia, BCR-ABL1 negative

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Diagnosis of chronic myelogenous leukemia in chronic phase Previously untreated Patients negative for Philadelphia chromosome and BCR-ABL translocation must fulfill at least 1 of the following criteria: Impaired health status with reduced exercise tolerance Spleen-related symptoms in cases of splenomegaly Weight loss greater than 10% in 6 months Fever greater than 38.5 degrees C on 5 consecutive days Clinically relevant bone pain Leukocytosis greater than 5,000/mm^3 Thrombocytosis greater than 100,000/mm^3 PATIENT CHARACTERISTICS: Age: Any age Performance status: Not specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: Not specified Renal: Not specified Other: No other concurrent malignancy that is likely to require treatment during study or that is likely to reduce life expectancy No severe concurrent disease or other cause that would preclude study Not pregnant PRIOR CONCURRENT THERAPY: Biologic therapy: No prior interferon Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: Not specified

Sites / Locations

  • Masaryk University Hospital
  • Haematologisch Onkologische Praxis
  • Kinderklinik - Universitaetsklinikum Aachen
  • Urologische Klinik - Universitaetsklinikum Aachen
  • Kreiskrankenhaus
  • Klinikum St. Marien
  • Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
  • II. Medizinische Klinik
  • Haematologische Praxis
  • Klinikum Augsburg
  • Kreiskrankenhaus
  • Krankenhaus Hohe Warte Mediziniche Klinik
  • St. Hedwig Kranken Haus
  • Tumorzentrum Berlin-Moabit
  • Wenckebach - Krankenhaus
  • Helios Klinikum Berlin
  • Haematologisch-Onkologische Schwerpunktpraxis
  • Charite - Campus Charite Mitte
  • Onkolog - Haematolog Schwerpunktpraxis
  • Krankenhaus Neukoelln
  • Charite - Campus Virchow Klinikum
  • Kinderklinik der Freier Universitaet Berlin
  • Onkologische Schwerpunktpraxis Bielefeld
  • Franziskus Hospital
  • Krankenhaus Bietigheim
  • Europahochhaus
  • Kreiskrankenhaus Boeblingen
  • Universitaetsklinikum Bonn
  • Medizinische Poliklinik
  • Marienhospital Bottrop gGmbH
  • Staedtisches Klinikum Braunschweig
  • Klinikum Bremen-Mitte
  • St. Joseph Hospital
  • Zentralkrankenhaus
  • Medizinische Klinik Am Lukas - Krankenhaus
  • Klinikum Coburg
  • Praxis Gemeinschaft
  • Praxis Fuer Haematologie Internistische Onkologie
  • Medizinische Universitaetsklinik I at the University of Cologne
  • Onkologische Schwerpunktpraxis
  • Stadt. KH Dresden - Neustadt
  • Medizinische Klinik I
  • Krankenhaus Dueren
  • Universitaetsklinikum Duesseldorf
  • Michael Schaefers und Partner
  • St. Johannes Hospital - Medical Klinik II
  • Hans - Susemihl - Krankenhaus
  • Internistiche Praxis
  • Klinikum Erfurt
  • Praxis DR. J. Weniger
  • Onkologische Schwerpunkt Praxis
  • Medizinische Klinik III - Universitaetsklinikum Erlangen
  • St. Antonius Hospital
  • Universitaetsklinikum Essen
  • Evangelisches Krankenhaus Essen Werden
  • Malteser Krankenhaus
  • Onkolog Gemeinschaftspraxis
  • Klinikum der J.W. Goethe Universitaet
  • Universitaetsklinikum Freiburg
  • II Medizinische Klinik - Klinikum Fuerth
  • Kreiskrankenhaus Fuessen
  • Klinikum Garmisch - Partenkirchen GmbH
  • Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
  • Klinik und Poliklinik fuer Urologie und Kinderurologie
  • Klinik fuer Radioonkologie und Strahlentherapie
  • Universitaetsklinikum Goettingen
  • DR Herbert - Nieper Krankenhaus Goslar
  • Allgemeines Krankenhaus Hagen
  • St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
  • Allgemeines Krankenhaus Altona
  • Hermann - Holthusen Institute for Radiotherapy
  • Universitaetsklinikum Hamburg-Eppendorf
  • Onkologischer Schwerpunkt Lerchenfeld
  • Asklepios Klinik Barmbek
  • Haematologisch-Onkologische Praxis Altona
  • Evangelische Krankenhaus Hamm
  • St. Marien-Hospital Hamm - Klinik Knappenstrasse
  • Haematologie Und Internistische Onkologie
  • Krankenhaus Siloah - Medizinische Klinik II
  • Medizinische Hochschule Hannover
  • Medizinische Universitaetsklinik und Poliklinik
  • Klinikum Herford
  • Universitaetsklinikum des Saarlandes
  • Clinic for Bone Marrow Transplantation and Hematology and Oncology
  • Praxis am Evangelischen Krankenhaus Bethanien
  • Klinikum der Friedrich-Schiller Universitaet Jena
  • Diakonissen - Krankenhaus
  • Staedtisches Klinikum Karlsruhe gGmbH
  • Gemeinschaftspraxis Brunoehler
  • St. Vincentius-Kliniken
  • Klinikum Kassel
  • Klinikum Kempten Oberallgaeu
  • University Hospital Schleswig-Holstein - Kiel Campus
  • Klinik Konstanz
  • Haematologische / Onkologische Schwerpunktpraxis
  • Klinikum Krefeld GmbH
  • Vinzentiuskrankenhaus
  • Caritas - Krakenhaus Lebach
  • Onkologische Schwerpunktpraxis - Leer
  • Klinikum Lippe - Lemgo
  • Luisenkrankenhaus
  • Klinikum der Stadt Ludwigshafen am Rhein
  • St Marienkrankenhaus
  • Praxis Fuer Haematologie/Onkologie
  • Onkologische Schwerpunktpraxis Lueneburg
  • Gemeinschaftspraxis
  • III Medizinische Klinik Mannheim
  • Philipps-Universitaet Marburg Klinikum
  • Kreiskrankenhaus Mellrichstadt
  • Klinikum Minden
  • Krankenhaus Maria Hilf GmbH
  • Universitaets - Kinderpoliklinik
  • Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
  • Gemeinschaftspraxis
  • Krankenhaus Muenchen Schwabing
  • Medizinische Kl. Klinikum Innenstadt Universitaet Muenchen
  • Praxis fuer Innere Medizin und Haematologie
  • Klinikum der Universitaet Muenchen - Grosshadern Campus
  • Staedtisches Krankenhaus Muenchen - Harlaching
  • Klinikum Rechts Der Isar - Technische Universitaet Muenchen
  • Krankenhaus Muenchen Neuperlach
  • Ruppiner Klinikum GMBH
  • Gemeinschaftspraxis
  • Praxis fuer Haematologie und Interne Onkologie
  • Gemeinschaftspraxis
  • Klinikum Nuernberg - Klinikum Nord
  • Klinikum Nuernberg - Klinikum Sued
  • Hematologische Praxis
  • Klinikum Oldenburg
  • Paracelsus - Klinik Osnabrueck
  • Staedtisches Krankenhaus
  • Kreiskrankenhaus Radebeul
  • St. Elisabeth Krankenhaus
  • Prosper-Hospital Recklinghausen
  • Hematologische Onkologische Praxis
  • Krankenhaus Barmherzige Brueder Regensburg
  • Klinikum der Universitaet Regensburg
  • Klinikum Remscheid GmbH
  • Jakobi Krankenhaus
  • Caritasklinik St. Theresia
  • Schwerpunktpraxis fuer Haematologie und Onkologie
  • Saechsische Schweiz Klinik
  • Staedt Krankenhaus
  • St. Marien - Krankenhaus Siegen GMBH
  • Kreiskrankenhaus Siegen
  • Klinikum Der Hansestadt Stralsund - Klin. West
  • Robert-Bosch-Krankenhaus
  • Haematologische Praxis
  • Klinik fuer Onkologie - Katharinenhospital Stuttgart
  • Diakonie Klinikum Stuttgart
  • Krankenanstalt Mutterhaus der Borromaerinnen
  • Praxis Fuer Internistische Haematologie / Onkologie
  • Schwerpunktpraxis für Rheumatologie und Haematologie/Internistische Onkologie
  • Southwest German Cancer Center at Eberhard-Karls-University
  • Bundeswehr Krakenhaus
  • Universitaetsklinikum Ulm
  • St. Irmgardis Krankenhaus
  • Klinikum Der Stadt Villingen - Schwenningen
  • Krankenhaus St. Michael
  • Kreiskrankenhaus
  • Deutsche Klinik fuer Diagnostik
  • St. Willehad Hospital
  • Kliniken St. Antonius
  • Praxis Fuer Haemotologie Und Internistischer Onkologie
  • Helios Kliniken Wuppertal University Hospital
  • Medical University of Gdansk
  • Silesian Medical Academy
  • Hospital Universitario Virgen de la Victoria
  • Kantonspital Aarau
  • Facharzt FMH Fuer Innere Medizin and Oncology
  • Universitaetsspital-Basel
  • Oncology Institute of Southern Switzerland
  • Facharzt Fuer Onkologie-Hematologie
  • Inselspital Bern
  • Inneremedizin FMH
  • Bezirksspital Dornach
  • Hopital Cantonal Universitaire de Geneve
  • FMH f. Innere Medizin and Hematologie
  • Centre Hospitalier Universitaire Vaudois
  • Kantonsspital, Luzerne
  • Institut Central des Hopitaux Valaisans
  • Kantonsspital - St. Gallen
  • Klinik Hirslanden
  • UniversitaetsSpital Zuerich

Outcomes

Primary Outcome Measures

Survival
Frequency, time-point, and duration of hematologic and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCL-ABL-positive cells
Correlation of quality of hematological and cytogenetic remission with survival time
Course of the terminal phase
Toxicity
Effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time
Effect of early vs late high-dose therapy and autografting on feasibility, toxicity and survival times

Secondary Outcome Measures

Full Information

First Posted
October 11, 2001
Last Updated
December 17, 2013
Sponsor
III. Medizinische Klinik Mannheim
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1. Study Identification

Unique Protocol Identification Number
NCT00025402
Brief Title
Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia
Official Title
Randomized Multicenter Treatment Optimization Study In Chronic Myeloid Leukemia (CML) Interferon-a Vs. Allogeneic Stem Cell Transplantation Vs. High-Dose Chemotherapy Followed By Autografting And Interferon-a Maintainance In Early Chronic Phase
Study Type
Interventional

2. Study Status

Record Verification Date
July 2002
Overall Recruitment Status
Unknown status
Study Start Date
July 1997 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
III. Medizinische Klinik Mannheim

4. Oversight

5. Study Description

Brief Summary
RATIONALE: Giving chemotherapy, such as hydroxyurea, cytarabine, idarubicin, and etoposide before a donor bone marrow transplant or stem cell transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. Interferon alfa may interfere with the growth of cancer cells and slow the growth of cancer. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. It is not yet known whether chemotherapy is more effective with or without interferon alfa and/or bone marrow or stem cell transplant in treating patients with chronic myelogenous leukemia. PURPOSE: This randomized phase III trial is studying chemotherapy and biological therapy to see how well it works compared with chemotherapy, biological therapy, and donor bone marrow transplant or autologous stem cell transplant in treating patients with chronic phase chronic myelogenous leukemia.
Detailed Description
OBJECTIVES: Compare survival in patients with chronic myelogenous leukemia in early chronic phase treated with allogeneic bone marrow transplantation vs drug treatment with or without autologous peripheral blood stem cell transplantation. Compare survival of patients with late-phase disease treated with high-dose cytarabine vs low-dose cytarabine followed by autografting and interferon alfa maintenance. Compare survival of patients not responding cytogenetically to treatment with continued interferon alfa vs hydroxyurea. Determine frequency, time-point, and duration of hematological and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCR-ABL-positive cells on the various treatments. Correlate the quality of hematological and cytogenetic remissions with survival time in patients treated with these regimens. Compare the course of the terminal phase in patients treated with these regimens. Compare the toxic effects of these regimens in these patients. Determine the effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time in patients treated with these regimens. Compare the effect of early vs late high-dose therapy plus autografting on feasibility, toxicity, and survival times in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to eligibility for transplantation (yes vs no). All patients undergo cytoreduction comprising hydroxyurea (HU) IV daily. Patients who are ineligible for or refuse transplantation are randomized to 1 of 2 treatment arms. Arm I: Patients receive interferon alfa (IFN) subcutaneously (SC) daily. After 2 weeks of IFN therapy, patients also receive low-dose cytarabine (ARA-C) SC once daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive HU. Arm II: Patients receive IFN SC daily. After 2 weeks of IFN therapy, patients also receive low-dose ARA-C SC daily for 10-15 days each month. Patients who do not achieve cytogenetic remission within 12 months continue to receive IFN therapy SC daily. Patients who are eligible for transplantation with a related donor undergo allogeneic bone marrow transplantation. Patients may receive HU or IFN prior to transplantation. Patients may also receive oral high-dose busulfan daily for 4 days with or without cyclophosphamide or cyclophosphamide with total body irradiation. Patients who are eligible for transplantation but do not have a related donor undergo peripheral blood stem cell (PBSC) harvest and are randomized to 1 of 2 treatment arms. Arm III: Patients receive IFN and low-dose ARA-C as in arm I. Patients who accelerate on treatment may undergo autologous PBSC transplantation. Arm IV: Patients receive idarubicin IV, ARA-C IV over 2 hours, and etoposide IV on days 1-3. Patients then undergo leukapheresis. Beginning on day 8, patients receive filgrastim (G-CSF) SC daily until end of leukapheresis. Patients then receive oral high-dose busulfan daily for 4 consecutive days. The following day, patients undergo reinfusion of autologous PBSC. After blood count recovery, patients receive maintenance IFN 3 times weekly for 8 weeks and then daily. Patients are followed every 3 months for 3 years and then every 6 months thereafter. PROJECTED ACCRUAL: A total of 1,000 patients will be accrued for this study within 5 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Leukemia
Keywords
chronic phase chronic myelogenous leukemia, chronic myelogenous leukemia, BCR-ABL1 positive, Philadelphia chromosome negative chronic myelogenous leukemia, childhood chronic myelogenous leukemia, atypical chronic myeloid leukemia, BCR-ABL1 negative

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Allocation
Randomized
Enrollment
1000 (Anticipated)

8. Arms, Groups, and Interventions

Intervention Type
Biological
Intervention Name(s)
filgrastim
Intervention Type
Biological
Intervention Name(s)
recombinant interferon alfa
Intervention Type
Drug
Intervention Name(s)
busulfan
Intervention Type
Drug
Intervention Name(s)
cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
cytarabine
Intervention Type
Drug
Intervention Name(s)
etoposide
Intervention Type
Drug
Intervention Name(s)
hydroxyurea
Intervention Type
Drug
Intervention Name(s)
idarubicin
Intervention Type
Procedure
Intervention Name(s)
allogeneic bone marrow transplantation
Intervention Type
Procedure
Intervention Name(s)
peripheral blood stem cell transplantation
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
Survival
Title
Frequency, time-point, and duration of hematologic and cytogenetic remissions and of Philadelphia chromosome-negative and/or BCL-ABL-positive cells
Title
Correlation of quality of hematological and cytogenetic remission with survival time
Title
Course of the terminal phase
Title
Toxicity
Title
Effect of prognostic criteria and normal or subnormal WBC on chronic phase duration and survival time
Title
Effect of early vs late high-dose therapy and autografting on feasibility, toxicity and survival times

10. Eligibility

Sex
All
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of chronic myelogenous leukemia in chronic phase Previously untreated Patients negative for Philadelphia chromosome and BCR-ABL translocation must fulfill at least 1 of the following criteria: Impaired health status with reduced exercise tolerance Spleen-related symptoms in cases of splenomegaly Weight loss greater than 10% in 6 months Fever greater than 38.5 degrees C on 5 consecutive days Clinically relevant bone pain Leukocytosis greater than 5,000/mm^3 Thrombocytosis greater than 100,000/mm^3 PATIENT CHARACTERISTICS: Age: Any age Performance status: Not specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: Not specified Renal: Not specified Other: No other concurrent malignancy that is likely to require treatment during study or that is likely to reduce life expectancy No severe concurrent disease or other cause that would preclude study Not pregnant PRIOR CONCURRENT THERAPY: Biologic therapy: No prior interferon Chemotherapy: No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: Not specified
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ruediger Hehlmann, MD
Organizational Affiliation
III. Medizinische Klinik Mannheim
Official's Role
Study Chair
Facility Information:
Facility Name
Masaryk University Hospital
City
Brno
ZIP/Postal Code
62500
Country
Czech Republic
Facility Name
Haematologisch Onkologische Praxis
City
Aachen
ZIP/Postal Code
D-52070
Country
Germany
Facility Name
Kinderklinik - Universitaetsklinikum Aachen
City
Aachen
ZIP/Postal Code
D-52074
Country
Germany
Facility Name
Urologische Klinik - Universitaetsklinikum Aachen
City
Aachen
ZIP/Postal Code
D-52074
Country
Germany
Facility Name
Kreiskrankenhaus
City
Aalen
ZIP/Postal Code
73430
Country
Germany
Facility Name
Klinikum St. Marien
City
Amberg
ZIP/Postal Code
D-92224
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Haematologie Und Internistische Onkologie
City
Ansbach
ZIP/Postal Code
91522
Country
Germany
Facility Name
II. Medizinische Klinik
City
Aschaffenburg
ZIP/Postal Code
RG 63739
Country
Germany
Facility Name
Haematologische Praxis
City
Augsburg
ZIP/Postal Code
86150
Country
Germany
Facility Name
Klinikum Augsburg
City
Augsburg
ZIP/Postal Code
DOH-86156
Country
Germany
Facility Name
Kreiskrankenhaus
City
Bad Hersfeld
ZIP/Postal Code
36251
Country
Germany
Facility Name
Krankenhaus Hohe Warte Mediziniche Klinik
City
Bayreuth
ZIP/Postal Code
95445
Country
Germany
Facility Name
St. Hedwig Kranken Haus
City
Berlin
ZIP/Postal Code
10115
Country
Germany
Facility Name
Tumorzentrum Berlin-Moabit
City
Berlin
ZIP/Postal Code
10967
Country
Germany
Facility Name
Wenckebach - Krankenhaus
City
Berlin
ZIP/Postal Code
12099
Country
Germany
Facility Name
Helios Klinikum Berlin
City
Berlin
ZIP/Postal Code
13125
Country
Germany
Facility Name
Haematologisch-Onkologische Schwerpunktpraxis
City
Berlin
ZIP/Postal Code
13357
Country
Germany
Facility Name
Charite - Campus Charite Mitte
City
Berlin
ZIP/Postal Code
D-10117
Country
Germany
Facility Name
Onkolog - Haematolog Schwerpunktpraxis
City
Berlin
ZIP/Postal Code
D-10559
Country
Germany
Facility Name
Krankenhaus Neukoelln
City
Berlin
ZIP/Postal Code
D-12313
Country
Germany
Facility Name
Charite - Campus Virchow Klinikum
City
Berlin
ZIP/Postal Code
D-13353
Country
Germany
Facility Name
Kinderklinik der Freier Universitaet Berlin
City
Berlin
ZIP/Postal Code
D-14059
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Bielefeld
City
Bielefeld
ZIP/Postal Code
D-33602
Country
Germany
Facility Name
Franziskus Hospital
City
Bietigheim
ZIP/Postal Code
74321
Country
Germany
Facility Name
Krankenhaus Bietigheim
City
Bietigheim
ZIP/Postal Code
74321
Country
Germany
Facility Name
Europahochhaus
City
Bochum
ZIP/Postal Code
44787
Country
Germany
Facility Name
Kreiskrankenhaus Boeblingen
City
Boeblingen
ZIP/Postal Code
71032
Country
Germany
Facility Name
Universitaetsklinikum Bonn
City
Bonn
ZIP/Postal Code
D-53105
Country
Germany
Facility Name
Medizinische Poliklinik
City
Bonn
ZIP/Postal Code
D-53111
Country
Germany
Facility Name
Marienhospital Bottrop gGmbH
City
Bottrop
ZIP/Postal Code
D-46236
Country
Germany
Facility Name
Staedtisches Klinikum Braunschweig
City
Braunschweig
ZIP/Postal Code
D-38114
Country
Germany
Facility Name
Klinikum Bremen-Mitte
City
Bremen
ZIP/Postal Code
D-28205
Country
Germany
Facility Name
St. Joseph Hospital
City
Bremerhaven
ZIP/Postal Code
D-27568
Country
Germany
Facility Name
Zentralkrankenhaus
City
Bremerhaven
ZIP/Postal Code
N 27574
Country
Germany
Facility Name
Medizinische Klinik Am Lukas - Krankenhaus
City
Buende
ZIP/Postal Code
32257
Country
Germany
Facility Name
Klinikum Coburg
City
Coburg
ZIP/Postal Code
96450
Country
Germany
Facility Name
Praxis Gemeinschaft
City
Cologne
ZIP/Postal Code
D-50676
Country
Germany
Facility Name
Praxis Fuer Haematologie Internistische Onkologie
City
Cologne
ZIP/Postal Code
D-50677
Country
Germany
Facility Name
Medizinische Universitaetsklinik I at the University of Cologne
City
Cologne
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis
City
Cottbus
ZIP/Postal Code
D-03046
Country
Germany
Facility Name
Stadt. KH Dresden - Neustadt
City
Dresden
ZIP/Postal Code
01129
Country
Germany
Facility Name
Medizinische Klinik I
City
Dresden
ZIP/Postal Code
D-01307
Country
Germany
Facility Name
Krankenhaus Dueren
City
Dueren
ZIP/Postal Code
52351
Country
Germany
Facility Name
Universitaetsklinikum Duesseldorf
City
Duesseldorf
ZIP/Postal Code
D-40225
Country
Germany
Facility Name
Michael Schaefers und Partner
City
Duisburg
ZIP/Postal Code
D-47051
Country
Germany
Facility Name
St. Johannes Hospital - Medical Klinik II
City
Duisburg
ZIP/Postal Code
D-47166
Country
Germany
Facility Name
Hans - Susemihl - Krankenhaus
City
Emden
ZIP/Postal Code
26721
Country
Germany
Facility Name
Internistiche Praxis
City
Erfurt
ZIP/Postal Code
99084
Country
Germany
Facility Name
Klinikum Erfurt
City
Erfurt
ZIP/Postal Code
99089
Country
Germany
Facility Name
Praxis DR. J. Weniger
City
Erfurt
ZIP/Postal Code
D-99085
Country
Germany
Facility Name
Onkologische Schwerpunkt Praxis
City
Erlangen
ZIP/Postal Code
D-91052
Country
Germany
Facility Name
Medizinische Klinik III - Universitaetsklinikum Erlangen
City
Erlangen
ZIP/Postal Code
D-91054
Country
Germany
Facility Name
St. Antonius Hospital
City
Eschweiler
ZIP/Postal Code
DOH-52249
Country
Germany
Facility Name
Universitaetsklinikum Essen
City
Essen
ZIP/Postal Code
D-45122
Country
Germany
Facility Name
Evangelisches Krankenhaus Essen Werden
City
Essen
ZIP/Postal Code
D-45239
Country
Germany
Facility Name
Malteser Krankenhaus
City
Flensburg
ZIP/Postal Code
D-24939
Country
Germany
Facility Name
Onkolog Gemeinschaftspraxis
City
Frankfurt
ZIP/Postal Code
60389
Country
Germany
Facility Name
Klinikum der J.W. Goethe Universitaet
City
Frankfurt
ZIP/Postal Code
D-60590
Country
Germany
Facility Name
Universitaetsklinikum Freiburg
City
Freiburg
ZIP/Postal Code
D-79106
Country
Germany
Facility Name
II Medizinische Klinik - Klinikum Fuerth
City
Fuerth
ZIP/Postal Code
D-90766
Country
Germany
Facility Name
Kreiskrankenhaus Fuessen
City
Fuessen
ZIP/Postal Code
87629
Country
Germany
Facility Name
Klinikum Garmisch - Partenkirchen GmbH
City
Garmisch-Partenkirchen
ZIP/Postal Code
D-82467
Country
Germany
Facility Name
Gemeinschaftspraxis Fuer Innere Medizin, Hematologie Und Onkologie
City
Giessen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Klinik und Poliklinik fuer Urologie und Kinderurologie
City
Giessen
ZIP/Postal Code
D-35392
Country
Germany
Facility Name
Klinik fuer Radioonkologie und Strahlentherapie
City
Goeppingen
ZIP/Postal Code
73035
Country
Germany
Facility Name
Universitaetsklinikum Goettingen
City
Goettingen
ZIP/Postal Code
D-37075
Country
Germany
Facility Name
DR Herbert - Nieper Krankenhaus Goslar
City
Goslar
ZIP/Postal Code
38642
Country
Germany
Facility Name
Allgemeines Krankenhaus Hagen
City
Hagen
ZIP/Postal Code
D-58095
Country
Germany
Facility Name
St. Marien Hospital - Katholisches Krankenhaus Hagen gGmbH
City
Hagen
ZIP/Postal Code
D-58095
Country
Germany
Facility Name
Allgemeines Krankenhaus Altona
City
Hamburg
ZIP/Postal Code
22763
Country
Germany
Facility Name
Hermann - Holthusen Institute for Radiotherapy
City
Hamburg
ZIP/Postal Code
D-20099
Country
Germany
Facility Name
Universitaetsklinikum Hamburg-Eppendorf
City
Hamburg
ZIP/Postal Code
D-20246
Country
Germany
Facility Name
Onkologischer Schwerpunkt Lerchenfeld
City
Hamburg
ZIP/Postal Code
D-22081
Country
Germany
Facility Name
Asklepios Klinik Barmbek
City
Hamburg
ZIP/Postal Code
D-22291
Country
Germany
Facility Name
Haematologisch-Onkologische Praxis Altona
City
Hamburg
ZIP/Postal Code
D-22767
Country
Germany
Facility Name
Evangelische Krankenhaus Hamm
City
Hamm
ZIP/Postal Code
D-59063
Country
Germany
Facility Name
St. Marien-Hospital Hamm - Klinik Knappenstrasse
City
Hamm
ZIP/Postal Code
D-59071
Country
Germany
Facility Name
Haematologie Und Internistische Onkologie
City
Hanau
ZIP/Postal Code
63450
Country
Germany
Facility Name
Krankenhaus Siloah - Medizinische Klinik II
City
Hannover
ZIP/Postal Code
D-30449
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
ZIP/Postal Code
D-30625
Country
Germany
Facility Name
Medizinische Universitaetsklinik und Poliklinik
City
Heidelberg
ZIP/Postal Code
69115
Country
Germany
Facility Name
Klinikum Herford
City
Herford
ZIP/Postal Code
D-32049
Country
Germany
Facility Name
Universitaetsklinikum des Saarlandes
City
Homburg
ZIP/Postal Code
66424
Country
Germany
Facility Name
Clinic for Bone Marrow Transplantation and Hematology and Oncology
City
Idar-Oberstein
ZIP/Postal Code
D-55743
Country
Germany
Facility Name
Praxis am Evangelischen Krankenhaus Bethanien
City
Iserlohn
ZIP/Postal Code
D-58644
Country
Germany
Facility Name
Klinikum der Friedrich-Schiller Universitaet Jena
City
Jena
ZIP/Postal Code
D-07740
Country
Germany
Facility Name
Diakonissen - Krankenhaus
City
Karlsruhe-Rueppur
ZIP/Postal Code
76199
Country
Germany
Facility Name
Staedtisches Klinikum Karlsruhe gGmbH
City
Karlsruhe
ZIP/Postal Code
76133
Country
Germany
Facility Name
Gemeinschaftspraxis Brunoehler
City
Karlsruhe
ZIP/Postal Code
76135
Country
Germany
Facility Name
St. Vincentius-Kliniken
City
Karlsruhe
ZIP/Postal Code
D-76137
Country
Germany
Facility Name
Klinikum Kassel
City
Kassel
ZIP/Postal Code
D-34125
Country
Germany
Facility Name
Klinikum Kempten Oberallgaeu
City
Kempten
ZIP/Postal Code
D-87439
Country
Germany
Facility Name
University Hospital Schleswig-Holstein - Kiel Campus
City
Kiel
ZIP/Postal Code
D-24105
Country
Germany
Facility Name
Klinik Konstanz
City
Konstanz
ZIP/Postal Code
78461
Country
Germany
Facility Name
Haematologische / Onkologische Schwerpunktpraxis
City
Krefeld
ZIP/Postal Code
47798
Country
Germany
Facility Name
Klinikum Krefeld GmbH
City
Krefeld
ZIP/Postal Code
D-47805
Country
Germany
Facility Name
Vinzentiuskrankenhaus
City
Landau
ZIP/Postal Code
D-76829
Country
Germany
Facility Name
Caritas - Krakenhaus Lebach
City
Lebach
ZIP/Postal Code
66822
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis - Leer
City
Leer
ZIP/Postal Code
D-26789
Country
Germany
Facility Name
Klinikum Lippe - Lemgo
City
Lemgo
ZIP/Postal Code
D-32657
Country
Germany
Facility Name
Luisenkrankenhaus
City
Lindenfels
ZIP/Postal Code
64678
Country
Germany
Facility Name
Klinikum der Stadt Ludwigshafen am Rhein
City
Ludwigshafen am Rhein
ZIP/Postal Code
D-67063
Country
Germany
Facility Name
St Marienkrankenhaus
City
Ludwigshafen, Rhein
ZIP/Postal Code
D-67067
Country
Germany
Facility Name
Praxis Fuer Haematologie/Onkologie
City
Luebeck
ZIP/Postal Code
D-23560
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Lueneburg
City
Lueneburg
ZIP/Postal Code
D-21391
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Mannheim
ZIP/Postal Code
D-68161
Country
Germany
Facility Name
III Medizinische Klinik Mannheim
City
Mannheim
ZIP/Postal Code
D-68305
Country
Germany
Facility Name
Philipps-Universitaet Marburg Klinikum
City
Marburg
ZIP/Postal Code
D-35033
Country
Germany
Facility Name
Kreiskrankenhaus Mellrichstadt
City
Mellrichstad
ZIP/Postal Code
DT-97638
Country
Germany
Facility Name
Klinikum Minden
City
Minden
ZIP/Postal Code
D-32423
Country
Germany
Facility Name
Krankenhaus Maria Hilf GmbH
City
Moenchengladbach
ZIP/Postal Code
DOH-41063
Country
Germany
Facility Name
Universitaets - Kinderpoliklinik
City
Muenchen
ZIP/Postal Code
80336
Country
Germany
Facility Name
Klinik und Poliklinik fuer Kinder und Jugendmedizin - Universitaetsklinikum Muenster
City
Muenster
ZIP/Postal Code
D-48129
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Munich
ZIP/Postal Code
80331
Country
Germany
City
Munich
ZIP/Postal Code
80637
Country
Germany
Facility Name
Krankenhaus Muenchen Schwabing
City
Munich
ZIP/Postal Code
80804
Country
Germany
Facility Name
Medizinische Kl. Klinikum Innenstadt Universitaet Muenchen
City
Munich
ZIP/Postal Code
D-80336
Country
Germany
Facility Name
Praxis fuer Innere Medizin und Haematologie
City
Munich
ZIP/Postal Code
D-80797
Country
Germany
City
Munich
ZIP/Postal Code
D-81241
Country
Germany
Facility Name
Klinikum der Universitaet Muenchen - Grosshadern Campus
City
Munich
ZIP/Postal Code
D-81377
Country
Germany
Facility Name
Staedtisches Krankenhaus Muenchen - Harlaching
City
Munich
ZIP/Postal Code
D-81545
Country
Germany
Facility Name
Klinikum Rechts Der Isar - Technische Universitaet Muenchen
City
Munich
ZIP/Postal Code
D-81675
Country
Germany
Facility Name
Krankenhaus Muenchen Neuperlach
City
Munich
ZIP/Postal Code
D-81737
Country
Germany
Facility Name
Ruppiner Klinikum GMBH
City
Neuruppin
ZIP/Postal Code
16816
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Niddatel-IIbenstadt
ZIP/Postal Code
61194
Country
Germany
Facility Name
Praxis fuer Haematologie und Interne Onkologie
City
Norderstedt
ZIP/Postal Code
22844
Country
Germany
Facility Name
Gemeinschaftspraxis
City
Nuernberg
ZIP/Postal Code
D-90402
Country
Germany
Facility Name
Klinikum Nuernberg - Klinikum Nord
City
Nuernberg
ZIP/Postal Code
D-90419
Country
Germany
Facility Name
Klinikum Nuernberg - Klinikum Sued
City
Nuernberg
ZIP/Postal Code
D-90471
Country
Germany
Facility Name
Hematologische Praxis
City
Oldenburg
ZIP/Postal Code
26121
Country
Germany
Facility Name
Klinikum Oldenburg
City
Oldenburg
ZIP/Postal Code
D-26133
Country
Germany
Facility Name
Paracelsus - Klinik Osnabrueck
City
Osnabrueck
ZIP/Postal Code
D-49076
Country
Germany
Facility Name
Staedtisches Krankenhaus
City
Pforzheim
ZIP/Postal Code
75175
Country
Germany
Facility Name
Kreiskrankenhaus Radebeul
City
Radebeul
ZIP/Postal Code
D-01445
Country
Germany
Facility Name
St. Elisabeth Krankenhaus
City
Ravensburg
ZIP/Postal Code
88212
Country
Germany
Facility Name
Prosper-Hospital Recklinghausen
City
Recklinghausen
ZIP/Postal Code
D-45659
Country
Germany
Facility Name
Hematologische Onkologische Praxis
City
Regensburg
ZIP/Postal Code
93047
Country
Germany
Facility Name
Krankenhaus Barmherzige Brueder Regensburg
City
Regensburg
ZIP/Postal Code
D-93049
Country
Germany
Facility Name
Klinikum der Universitaet Regensburg
City
Regensburg
ZIP/Postal Code
D-93053
Country
Germany
Facility Name
Klinikum Remscheid GmbH
City
Remscheid
ZIP/Postal Code
D-42859
Country
Germany
Facility Name
Jakobi Krankenhaus
City
Rheine
ZIP/Postal Code
48431
Country
Germany
Facility Name
Caritasklinik St. Theresia
City
Saarbrucken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
Schwerpunktpraxis fuer Haematologie und Onkologie
City
Saarbruecken
ZIP/Postal Code
D-66113
Country
Germany
Facility Name
Saechsische Schweiz Klinik
City
Sebnitz
ZIP/Postal Code
D-01855
Country
Germany
Facility Name
Staedt Krankenhaus
City
Sebnitz
ZIP/Postal Code
D-01855
Country
Germany
Facility Name
St. Marien - Krankenhaus Siegen GMBH
City
Siegen
ZIP/Postal Code
D-57072
Country
Germany
Facility Name
Kreiskrankenhaus Siegen
City
Siegen
ZIP/Postal Code
D-57076
Country
Germany
Facility Name
Klinikum Der Hansestadt Stralsund - Klin. West
City
Stralsund
ZIP/Postal Code
D-18410
Country
Germany
Facility Name
Robert-Bosch-Krankenhaus
City
Stuttgart
ZIP/Postal Code
70376
Country
Germany
Facility Name
Haematologische Praxis
City
Stuttgart
ZIP/Postal Code
D-70173
Country
Germany
Facility Name
Klinik fuer Onkologie - Katharinenhospital Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70174
Country
Germany
Facility Name
Diakonie Klinikum Stuttgart
City
Stuttgart
ZIP/Postal Code
D-70176
Country
Germany
Facility Name
Krankenanstalt Mutterhaus der Borromaerinnen
City
Trier
ZIP/Postal Code
D-54219
Country
Germany
City
Trier
ZIP/Postal Code
D-54290
Country
Germany
Facility Name
Praxis Fuer Internistische Haematologie / Onkologie
City
Troisdorf
ZIP/Postal Code
53840
Country
Germany
Facility Name
Schwerpunktpraxis für Rheumatologie und Haematologie/Internistische Onkologie
City
Tuebingen
ZIP/Postal Code
D-72072
Country
Germany
Facility Name
Southwest German Cancer Center at Eberhard-Karls-University
City
Tuebingen
ZIP/Postal Code
D-72076
Country
Germany
Facility Name
Bundeswehr Krakenhaus
City
Ulm
ZIP/Postal Code
D-89070
Country
Germany
Facility Name
Universitaetsklinikum Ulm
City
Ulm
ZIP/Postal Code
D-89081
Country
Germany
Facility Name
St. Irmgardis Krankenhaus
City
Viersen-Suechteln
ZIP/Postal Code
41749
Country
Germany
Facility Name
Klinikum Der Stadt Villingen - Schwenningen
City
Villingen-Schwenningen
ZIP/Postal Code
D-78054
Country
Germany
Facility Name
Krankenhaus St. Michael
City
Voeklingen
ZIP/Postal Code
66333
Country
Germany
Facility Name
Kreiskrankenhaus
City
Waldroel
ZIP/Postal Code
51545
Country
Germany
Facility Name
Deutsche Klinik fuer Diagnostik
City
Wiesbaden
ZIP/Postal Code
D-65191
Country
Germany
Facility Name
St. Willehad Hospital
City
Wilhelmshaven
ZIP/Postal Code
D-26382
Country
Germany
Facility Name
Kliniken St. Antonius
City
Wuppertal 2
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Praxis Fuer Haemotologie Und Internistischer Onkologie
City
Wuppertal
ZIP/Postal Code
42105
Country
Germany
Facility Name
Helios Kliniken Wuppertal University Hospital
City
Wuppertal
ZIP/Postal Code
D-42283
Country
Germany
Facility Name
Medical University of Gdansk
City
Gdansk
ZIP/Postal Code
80-211
Country
Poland
Facility Name
Silesian Medical Academy
City
Katowice
ZIP/Postal Code
40-029
Country
Poland
Facility Name
Hospital Universitario Virgen de la Victoria
City
Malaga
ZIP/Postal Code
29010
Country
Spain
Facility Name
Kantonspital Aarau
City
Aarau
ZIP/Postal Code
CH-5001
Country
Switzerland
Facility Name
Facharzt FMH Fuer Innere Medizin and Oncology
City
Baar
ZIP/Postal Code
CH-6340
Country
Switzerland
City
Basel
ZIP/Postal Code
CH 4051
Country
Switzerland
Facility Name
Universitaetsspital-Basel
City
Basel
ZIP/Postal Code
CH-4031
Country
Switzerland
Facility Name
Oncology Institute of Southern Switzerland
City
Bellinzona
ZIP/Postal Code
CH-6500
Country
Switzerland
Facility Name
Facharzt Fuer Onkologie-Hematologie
City
Bern
ZIP/Postal Code
3013
Country
Switzerland
Facility Name
Inselspital Bern
City
Bern
ZIP/Postal Code
CH-3010
Country
Switzerland
Facility Name
Inneremedizin FMH
City
Breitenbach
ZIP/Postal Code
4226
Country
Switzerland
Facility Name
Bezirksspital Dornach
City
Dornach
ZIP/Postal Code
CH-4143
Country
Switzerland
Facility Name
Hopital Cantonal Universitaire de Geneve
City
Geneva
ZIP/Postal Code
CH-1211
Country
Switzerland
Facility Name
FMH f. Innere Medizin and Hematologie
City
Grosshochstetten
ZIP/Postal Code
3506
Country
Switzerland
Facility Name
Centre Hospitalier Universitaire Vaudois
City
Lausanne
ZIP/Postal Code
CH-1011
Country
Switzerland
Facility Name
Kantonsspital, Luzerne
City
Luzerne
ZIP/Postal Code
CH-6016
Country
Switzerland
Facility Name
Institut Central des Hopitaux Valaisans
City
Sion
ZIP/Postal Code
CH-1951
Country
Switzerland
Facility Name
Kantonsspital - St. Gallen
City
St. Gallen
ZIP/Postal Code
CH-9007
Country
Switzerland
Facility Name
Klinik Hirslanden
City
Zurich
ZIP/Postal Code
CH-8008
Country
Switzerland
Facility Name
UniversitaetsSpital Zuerich
City
Zurich
ZIP/Postal Code
CH-8091
Country
Switzerland

12. IPD Sharing Statement

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Chemotherapy and Biological Therapy With or Without Bone Marrow or Peripheral Stem Cell Transplant in Treating Patients With Chronic Myelogenous Leukemia

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