Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors
Ovarian Cancer, Sarcoma, Small Intestine Cancer
About this trial
This is an interventional treatment trial for Ovarian Cancer focused on measuring chondrosarcoma, small intestine leiomyosarcoma, fibrosarcomatous osteosarcoma, embryonal childhood rhabdomyosarcoma, alveolar childhood rhabdomyosarcoma, pleomorphic childhood rhabdomyosarcoma, mixed childhood rhabdomyosarcoma, embryonal-botryoid childhood rhabdomyosarcoma, metastatic childhood soft tissue sarcoma, extraosseous Ewing sarcoma/peripheral primitive neuroectodermal tumor, childhood fibrosarcoma, childhood synovial sarcoma, childhood malignant hemangiopericytoma, childhood liposarcoma, childhood alveolar soft-part sarcoma, childhood leiomyosarcoma, childhood angiosarcoma, childhood epithelioid sarcoma, childhood malignant mesenchymoma, stage IV uterine sarcoma, uterine leiomyosarcoma, ovarian sarcoma, previously untreated childhood rhabdomyosarcoma, childhood desmoplastic small round cell tumor
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed metastatic rhabdomyosarcoma or other malignant mesenchymal tumors Standard risk defined as: Less than 10 years of age No bone or bone marrow involvement High risk defined as: At least 10 years of age OR Bone or bone marrow involvement Diagnosed less than 8 weeks ago Previously untreated disease except for initial surgery within the past 8 weeks PATIENT CHARACTERISTICS: Age: 6 months to under 18 years Performance status: Not specified Life expectancy: Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified PRIOR CONCURRENT THERAPY: Biologic therapy: No prior biologic therapy Chemotherapy: No prior chemotherapy Endocrine therapy: No prior endocrine therapy Radiotherapy: Concurrent radiotherapy allowed Surgery: See Disease Characteristics
Sites / Locations
- Centre Leon Berard
- Our Lady's Hospital for Sick Children
- Birmingham Children's Hospital
- Bristol Royal Hospital for Children
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Leicester Royal Infirmary
- Royal Liverpool Children's Hospital, Alder Hey
- Saint Bartholomew's Hospital
- Leeds Cancer Centre at St. James's University Hospital
- Great Ormond Street Hospital for Children NHS Trust
- Meyerstein Institute of Oncology at University College of London Hospitals
- Central Manchester and Manchester Children's University Hospitals NHS Trust
- Newcastle Upon Tyne Hospitals NHS Trust
- Queen's Medical Centre
- Oxford Radcliffe Hospital
- Children's Hospital - Sheffield
- Southampton General Hospital
- Royal Marsden NHS Foundation Trust - Surrey
- Royal Belfast Hospital for Sick Children
- Aberdeen Royal Infirmary
- Royal Hospital for Sick Children
- Royal Hospital for Sick Children