Brain Activation in Vocal and Motor Tics
Tourette's Syndrome, Chronic Motor Tic Disorder, Chronic Motor Vocal Disorder
About this trial
This is an observational trial for Tourette's Syndrome focused on measuring Voluntary Movement, Basal Ganglia, Frontal Lobe, Motor Cortex, Motor Tic Disorder, Tourette's Syndrome, Vocal Tic Disorder, Tic, Healthy Volunteer, HV, Normal Control
Eligibility Criteria
INCLUSION CRITERIA Patients will have a clinically documented tic disorder as defined by DSM-IV-TR and evaluation of tics severity using Yale Tic Sale. This criterion will be established by the preliminary screening in the NINDS Movement Disorders Outpatient Clinic. Patients will be in age range 14 to 65. Patients may be male or female. Patients will be asked to stop any medications that can influence central nervous system for at least 24 hours prior to exam also they will be asked to abstain from alcohol for 24 hours before the study. 10 normal controls will be included; controls will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have neurological and physical examination. Controls with chronic illnesses, taking any medication that affects the CNS will be excluded. Controls will be asked to abstain from alcohol for 24 hours before the study. All subjects participating in MR studies should have a valid Clinical Center Medical Record Number. EXCLUSION CRITERIA Patients younger than 14 years old will be excluded from the study. Patients with MRI findings consistent with brain tumors, strokes, trauma or AVMs will be excluded. Patients with progressive neurological disorders other than a tic disorder will be excluded. Patients with a history of significant medical disorders, or requiring chronic treatment with other drugs, which cannot be stopped, will be excluded. Patients with cancer will be excluded. Pregnant women will be excluded. Patients not capable of giving informed consent will be excluded.
Sites / Locations
- National Institute of Neurological Disorders and Stroke (NINDS)