Pentostatin and Rituximab in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
Leukemia, Lymphoma
About this trial
This is an interventional treatment trial for Leukemia focused on measuring stage I chronic lymphocytic leukemia, stage II chronic lymphocytic leukemia, stage III chronic lymphocytic leukemia, stage IV chronic lymphocytic leukemia, refractory chronic lymphocytic leukemia, B-cell chronic lymphocytic leukemia, stage I grade 1 follicular lymphoma, stage I grade 2 follicular lymphoma, stage I grade 3 follicular lymphoma, stage III grade 1 follicular lymphoma, stage III grade 2 follicular lymphoma, stage III grade 3 follicular lymphoma, stage IV grade 1 follicular lymphoma, stage IV grade 2 follicular lymphoma, stage IV grade 3 follicular lymphoma, recurrent grade 1 follicular lymphoma, recurrent grade 2 follicular lymphoma, recurrent grade 3 follicular lymphoma, prolymphocytic leukemia, contiguous stage II grade 1 follicular lymphoma, contiguous stage II grade 2 follicular lymphoma, contiguous stage II grade 3 follicular lymphoma, noncontiguous stage II grade 1 follicular lymphoma, noncontiguous stage II grade 2 follicular lymphoma, noncontiguous stage II grade 3 follicular lymphoma, noncontiguous stage II small lymphocytic lymphoma, noncontiguous stage II marginal zone lymphoma, recurrent marginal zone lymphoma, recurrent small lymphocytic lymphoma, stage I marginal zone lymphoma, stage I small lymphocytic lymphoma, stage III small lymphocytic lymphoma, stage III marginal zone lymphoma, stage IV small lymphocytic lymphoma, stage IV marginal zone lymphoma, contiguous stage II marginal zone lymphoma, contiguous stage II small lymphocytic lymphoma, extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed low-grade non-Hodgkin's lymphoma REAL classification: B-cell chronic lymphocytic leukemia Prolymphocytic leukemia Small lymphocytic lymphoma Follicular center lymphoma (grade I, II, or III) Extranodal marginal zone B-cell lymphoma Malt type International Working Group classification: Small lymphocytic/chronic lymphocytic leukemia (CLL) CLL with lymph node involvement allowed Small lymphocytic plasmacytoid Follicular small cleaved cell Follicular mixed small and large cell Follicular predominantly large cell Measurable disease Lymph node more than 1 cm in longest transverse diameter NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: More than 6 months Hematopoietic: Absolute neutrophil count at least 1,000/mm^3 Platelet count at least 75,000/mm^3 Hemoglobin at least 9 g/dL Hepatic: Bilirubin no greater than 2.0 mg/dL AST no greater than 5 times upper limit of normal Renal: Creatinine less than 2.0 mg/dL BUN normal Urinalysis normal Cardiovascular: LVEF normal in patients with history of stable heart disease for at least 2 years Other: HIV negative No thyroid disease with thyroid function that cannot be maintained in the normal range No other prior malignancy unless progression free for more than 5 years Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Prior rituximab, Y2B8, or iodine I 131 tositumomab allowed provided at least 6 months have elapsed and patient has had clear disease progression No other concurrent immunotherapy Chemotherapy: No more than 6 prior chemotherapy drugs No more than 3 prior treatments with pentostatin At least 3 weeks since prior chemotherapy No prior cumulative lifetime dose of more than 480 mg/m2 of doxorubicin or an equivalent dose of any anthracycline No other concurrent chemotherapy Endocrine therapy: Not specified Radiotherapy: No concurrent radiotherapy to an indicator lesion Surgery: Not specified Other: No other concurrent investigational drug
Sites / Locations
- Cancer and Blood Institute of the Desert
- Redding Medical Center
- Oncology-Hematology Associates, P.A.
- North Shore Hematology/Oncology Associates, P.C.
- Hematology Oncology Associates of Central New York, P.C.