Combination Chemotherapy With or Without Thalidomide in Treating Patients With Multiple Myeloma
Multiple Myeloma and Plasma Cell Neoplasm
About this trial
This is an interventional treatment trial for Multiple Myeloma and Plasma Cell Neoplasm focused on measuring stage II multiple myeloma, stage III multiple myeloma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed multiple myeloma Stage II or III No systemic amyloid light-chain amyloidosis PATIENT CHARACTERISTICS: Age: 18 to 65 Performance status: WHO 0-3 Life expectancy: Not specified Hematopoietic: Not specified Hepatic: No significant hepatic dysfunction* Bilirubin less than 1.75 mg/dL* AST/ALT less than 2.5 times normal* NOTE: *Unless related to myeloma Renal: Not specified Cardiovascular: No severe cardiac dysfunction No New York Heart Association class II, III, or IV heart disease Other: HIV negative No active uncontrolled infection No other malignancy within the past 5 years except basal cell skin cancer or carcinoma in situ of the cervix No known intolerance to thalidomide Not pregnant Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Patients 18 to 55 years of age must not have been allocated before study randomization to allogeneic stem cell transplantation with an HLA-identical sibling donor Chemotherapy: No more than 2 prior courses of melphalan and prednisone therapy for local myeloma progression No other prior chemotherapy Endocrine therapy: Not specified Radiotherapy: Prior local radiotherapy for local myeloma progression allowed No other prior radiotherapy Surgery: Not specified
Sites / Locations
- U.Z. Gasthuisberg
- HagaZiekenhuis - Locatie Leyenburg
- Jeroen Bosch Ziekenhuis
- Meander Medisch Centrum
- Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital
- Vrije Universiteit Medisch Centrum
- Academisch Medisch Centrum at University of Amsterdam
- Medisch Spectrum Twente
- University Medical Center Groningen
- Medisch Centrum Leeuwarden - Zuid
- Leiden University Medical Center
- Academisch Ziekenhuis Maastricht
- Sint Antonius Ziekenhuis
- Universitair Medisch Centrum St. Radboud - Nijmegen
- Daniel Den Hoed Cancer Center at Erasmus Medical Center
- University Medical Center Utrecht
- Isala Klinieken - locatie Sophia