GM-CSF in Patients With Pulmonary Alveolar Proteinosis
Pulmonary Alveolar Proteinosis
About this trial
This is an interventional treatment trial for Pulmonary Alveolar Proteinosis focused on measuring Sargramostim, Injections, Subcutaneous
Eligibility Criteria
Inclusion criteria: Diagnosis of primary or idiopathic PAP Creatinine no greater than 2 mg/dL Bilirubin no greater than 2 mg/dL Liver enzymes no greater than 3 times normal Women must use an effective method of contraception, be post menopausal, or be surgically sterilized Exclusion criteria: Active respiratory infection Active cardiovascular disease (e.g., cardiogenic pulmonary edema) Underlying myeloproliferative disorder or leukemia Other secondary cause of PAP (e.g., occupational exposure to silica or HIV with PCP) At increased risk of side effects from GM-CSF therapy (i.e., rheumatoid arthritis, immune thrombocytopenia, or autoimmune thyroiditis) Previous therapy with GM-CSF Pregnant or nursing Significant renal or liver disease
Sites / Locations
- National Jewish Medical Center
- Cleveland Clinic Foundation
- The University of Pennsylvania Medical Center