Filgrastim or Pegfilgrastim in Preventing Neutropenia in Women Receiving Chemotherapy Following Surgery for Breast Cancer
Breast Cancer, Neutropenia
About this trial
This is an interventional supportive care trial for Breast Cancer focused on measuring neutropenia, stage I breast cancer, stage II breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed invasive breast cancer No locally advanced or metastatic breast cancer, including supraclavicular fossa metastases Prior neutropenic event on current chemotherapy regimen, defined as 1 of the following: Hospitalization due to neutropenia Absolute neutrophil count ≤ 1.5 times upper limit of normal and considered sufficiently low to require a treatment delay or a dose reduction > 15% of planned dose Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 18 and over Sex: Female Menopausal status: Not specified Performance status: Not specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics Hepatic: Not specified Renal: Not specified Other: No other concurrent malignancy Considered suitable risk and fitness status to continue adjuvant chemotherapy PRIOR CONCURRENT THERAPY: Biologic therapy: No prior filgrastim (G-CSF) or pegfilgrastim Chemotherapy: See Disease Characteristics No prior chemotherapy other than current regimen Endocrine therapy: Prior tamoxifen allowed Radiotherapy: Concurrent radiotherapy allowed No concurrent sandwich/synchronous radiotherapy (i.e., administered during a break in the chemotherapy regimen) Surgery: See Disease Characteristics Other: Concurrent enrollment on other licensed chemotherapy trials allowed provided G-CSF is not excluded (e.g., TACT or TANGO trials) Concurrent enrollment in the sequential arm of the SECRAB trial allowed (synchronous arm ineligible)
Sites / Locations
- City Hospital - Birmingham
- Sussex Cancer Centre at Royal Sussex County Hospital
- Cheltenham General Hospital
- Princess Alexandra Hospital
- St. Luke's Cancer Centre at Royal Surrey County Hospital
- King George Hospital
- Leeds Cancer Centre at St. James's University Hospital
- Queen Elizabeth Hospital NHS Trust
- King's College Hospital
- St. George's Hospital
- Christie Hospital NHS Trust
- Clatterbridge Centre for Oncology NHS Trust
- Northampton General Hospital NHS Trust
- Norfolk and Norwich University Hospital
- Nottingham City Hospital NHS Trust
- Royal Oldham Hospital
- Peterborough Hospitals Trust
- Berkshire Cancer Centre at Royal Berkshire Hospital
- Oldchurch Hospital
- Salisbury District Hospital
- Cancer Research Centre at Weston Park Hospital
- South Tyneside District Hospital
- Southampton University Hospital NHS Trust
- Sunderland Royal Hospital
- Southend University Hospital NHS Foundation Trust
- Yeovil District Hospital
- Ninewells Hospital and Medical School
- Scottish Cancer Therapy Network
- West of Scotland Cancer Centre
- Royal Infirmary - Castle
- Raigmore Hospital
- Singleton Hospital of the Swansea NHS Trust