Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer
Anorexia, Cachexia, Lung Cancer
About this trial
This is an interventional supportive care trial for Anorexia focused on measuring stage I non-small cell lung cancer, stage II non-small cell lung cancer, limited stage small cell lung cancer, stage IIIA non-small cell lung cancer, stage IIIB non-small cell lung cancer, anorexia, cachexia
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed lung cancer Unresectable stage I-IIIB non-small cell lung cancer (NSCLC) Resected stage I-IIIB NSCLC Limited stage small cell lung cancer Planned radiotherapy with a total dose of at least 5,000 cGy in fraction sizes of no greater than 200 cGy each No distant metastases No significant ascites, pleural effusions, or edema that would inhibit oral food intake or invalidate weight determinations PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-2 Life expectancy: More than 3 months Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified Cardiovascular: No uncontrolled hypertension No active thromboembolic disease No myocardial infarction within the past 3 months No prior congestive heart failure or thromboembolic events Pulmonary: No prior pulmonary edema Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception No other malignancy within the past 3 years except curatively treated carcinoma in situ of the cervix or non-melanoma skin cancer No uncontrolled diabetes with glycosylated hemoglobin greater than 10% No Cushing's syndrome No dietary restrictions (e.g., salt, sugar, or lipid) No other serious medical or psychiatric illness that would preclude study PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Endocrine therapy Endocrine therapy: At least 12 months since prior corticosteroids, estrogens, progestins, or other steroid hormone except as antiemetic prior to chemotherapy No concurrent corticosteroids, estrogens, progestins, or other steroid hormone except as antiemetic prior to chemotherapy Radiotherapy: See Disease Characteristics No prior radiotherapy to lung Surgery: See Disease Characteristics More than 14 days since prior surgery
Sites / Locations
- Comprehensive Cancer Center at Wake Forest University