Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus
Sarcoma
About this trial
This is an interventional treatment trial for Sarcoma focused on measuring stage IV uterine sarcoma, recurrent uterine sarcoma, uterine leiomyosarcoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed primary leiomyosarcoma (LMS) of the uterus Advanced, persistent, or recurrent disease that is refractory to curative therapy or established treatments At least 1 unidimensionally measurable target lesion At least 20 mm by conventional techniques (e.g., palpation, plain x-ray, CT scan, or MRI) OR At least 10 mm by spiral CT scan Tumors within a previously irradiated field are designated as non-target lesions Ineligible for a higher priority Gynecologic Oncology Group protocol (if one exists), including any active phase III protocol for the same population PATIENT CHARACTERISTICS: Age: 18 and over Performance status: GOG 0-2 Life expectancy: Not specified Hematopoietic: Absolute neutrophil count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN) SGOT no greater than 2.5 times ULN Alkaline phosphatase no greater than 2.5 times ULN Renal: Creatinine no greater than 1.5 times ULN Other: No active infection requiring antibiotics No grade 2 or greater sensory or motor neuropathy No other invasive malignancy within the past 5 years except nonmelanoma skin cancer PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior cytotoxic chemotherapy for LMS of the uterus Endocrine therapy: At least 1 week since prior hormonal therapy for LMS of the uterus Concurrent hormone replacement therapy allowed Radiotherapy: See Disease Characteristics Recovered from prior recent radiotherapy Surgery: Recovered from prior recent surgery Other: Recovered from other prior recent therapy No prior cancer treatment that would preclude study therapy
Sites / Locations
- Jonsson Comprehensive Cancer Center, UCLA
- University of Colorado Cancer Center
- Walter Reed Army Medical Center
- Rush-Presbyterian-St. Luke's Medical Center
- Holden Comprehensive Cancer Center
- Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support
- Tuft-New England Medical Center
- Mayo Clinic Cancer Center
- Washington University School of Medicine
- Cooper University Hospital
- State University of New York Health Sciences Center - Stony Brook
- Lineberger Comprehensive Cancer Center, UNC
- Duke Comprehensive Cancer Center
- Comprehensive Cancer Center at Wake Forest University
- Barrett Cancer Center
- University of Oklahoma College of Medicine
- Abington Memorial Hospital
- University of Pennsylvania Cancer Center
- University of Texas Medical Branch
- Tacoma General Hospital
- Norwegian Radium Hospital