Study of GABA-A Receptors in the Generation of Tics in Patients With Tourette's Syndrome
Tourette Syndrome
About this trial
This is an observational trial for Tourette Syndrome focused on measuring Basal Ganglia, Neuroimaging, Inhibitory Neurons, Disinhibition, Tics, Tourette's Syndrome, Tourette Syndrome, Healthy Volunteer, HV, Normal Control
Eligibility Criteria
INCLUSION CRITERIA: A. Patients will have clinically documented TS as defined by DSM-IV and evaluation of tics severity using Yale Tic Scale. This criterion will be established by the preliminary screening in the NINDS Movement Disorders Outpatient Clinic. B. Patients (either male or female) will range in age from 18 to 65 years. Female patients of child-bearing potential will have a pregnancy test prior to each PET and MRI scan and specific interview prior to the study to ensure that pregnant patients will not participate in the study. Patients will be asked to stop for two weeks prior to the exam any medication that can influence the CNS. Fluoxetine will be stopped for four weeks. They will be asked to abstain from alcohol for one week before the study. C. Seventeen normal controls will be included; controls will be screened in the NINDS Movement Disorders Outpatient Clinic, and will have neurological and physical examinations. Controls with chronic illnesses, taking any medication that affects the CNS will be excluded. They will be asked to abstain from alcohol for one week before the study. EXCLUSION CRITERIA: A. Patients younger than 18 years old and older than 65 will be excluded from the study. B. Patients with MRI findings consistent with brain tumors, strokes, trauma or AVMs will be excluded. C. Patients with progressive neurological disorders other than TS will be excluded. D. Patients with a history of significant medical disorders, or requiring chronic treatment with other drugs, which, cannot be stopped, will be excluded. E. Patients with cancer will be excluded. F. Patients incapable of giving an informed consent will be excluded. G. Patients who are pregnant or nursing.
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike