MRI Brain Studies in Patients With HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis
Tropical Spastic Paraparesis
About this trial
This is an observational trial for Tropical Spastic Paraparesis focused on measuring DTI, MRSI, MTR, NAWN, Fiber-Tract, Normal Control, Healthy Volunteer, HV, HTLV-1 Associated Myelopathy, Tropical Spastic Paraparesis, HAM/TSP
Eligibility Criteria
INCLUSION CRITERIA: Patients: A. Established Diagnosis of HAM/TSP as defined by Osame, Igata, and Matsumoto and subsequently confirmed by Gessain and Gout and the WHO. B. Age 18 or older C. An initial cohort of 5 HAM/TSP patients with established disease with EDSS levels of 6.0 or greater and duration of disease of 2 years or more will be investigated. If MRI abnormalities can be demonstrated, the group will be expanded to 20. Of this 20, at least 5 patients have been identified that will be HLA A201. Healthy Controls: A. No history of disease of the nervous system or autoimmune disease B. Age 18 or older C. Subjects shall be sex- and age-matched to our patients EXCLUSION CRITERIA: A subject will be excluded if he/she has a contraindication to MRI scanning such as the following: Aneurysm clip; Implanted neural stimulator; Implanted cardiac pacemaker or autodefibrillator; Cochlear implant; Ocular foreign body or implant (e.g. metal savings, retinal clips); breast implants; or Insulin pumps. Subjects will be excluded if they have claustrophobia. A pregnancy test will be administered to women of childbearing age. Pregnant women will be excluded from the studies.
Sites / Locations
- National Institute of Neurological Disorders and Stroke (NINDS)