A Study to Compare Anti-HIV Drugs Given Twice a Day or Once a Day, With or Without Direct Observation
HIV Infections
About this trial
This is an interventional treatment trial for HIV Infections focused on measuring Lopinavir, HIV-1, Drug Administration Schedule, Stavudine, HIV Protease Inhibitors, Ritonavir, Reverse Transcriptase Inhibitors, Self Care, Viral Load, Emtricitabine, Directly Observed Therapy, Tenofovir Disoproxil Fumarate, Treatment Naive
Eligibility Criteria
Inclusion Criteria HIV infection Age 13 years or older and have written consent of guardian if under 18 Weigh at least 88 pounds Viral load of 2000 copies/ml or more within 90 days before study entry Have not taken anti-HIV drugs for more than 7 days Agree to use acceptable methods of contraception during the study and for 1 month after stopping the study drugs Exclusion Criteria Pregnant or breastfeeding In jail Sensitive or allergic to any part of the study drugs Treated with acute systemic therapy for a serious infection or other serious medical illness within 7 days prior to study entry, unless the participant has completed 7 days of therapy and is clinically stable Recent serious illness, including pancreatitis or peripheral neuropathy Alcohol or illicit drug abuse Taken any of the following within 14 days before study entry: investigational drugs, anti-HIV vaccines, drugs that may cause pancreatitis or peripheral neuropathy, or drugs that are associated with CYP3A Treated for cancer (not including minimal Kaposi's sarcoma) within 30 days before study entry History of mental illness that might interfere with the study
Sites / Locations
- USC CRS
- Univ. of California Davis Med. Ctr., ACTU
- Ucsd, Avrc Crs
- University of Colorado Hospital CRS
- Univ. of Miami AIDS CRS
- Univ. of Hawaii at Manoa, Leahi Hosp.
- Indiana Univ. School of Medicine, Infectious Disease Research Clinic
- IHV Baltimore Treatment CRS
- Johns Hopkins Adult AIDS CRS
- SSTAR, Family Healthcare Ctr.
- University of Minnesota, ACTU
- Beth Israel Med. Ctr., ACTU
- NY Univ. HIV/AIDS CRS
- Univ. of Rochester ACTG CRS
- AIDS Care CRS
- McCree McCuller Wellness Ctr. at the Connection, Infectious Disease Unit
- Unc Aids Crs
- Regional Center for Infectious Disease, Wendover Medical Center CRS
- Wake County Health and Human Services CRS
- Univ. of Cincinnati CRS
- MetroHealth CRS
- The Ohio State Univ. AIDS CRS
- Hosp. of the Univ. of Pennsylvania CRS
- Pitt CRS
- The Miriam Hosp. ACTG CRS
- Vanderbilt Therapeutics CRS
- University of Washington AIDS CRS
- Puerto Rico-AIDS CRS
- Wits HIV CRS