Combination Chemotherapy With or Without Microwave Thermotherapy Before Surgery in Treating Women With Locally Advanced Breast Cancer
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage IIIA breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed locally advanced primary breast cancer Stage III (T2-3, N2-3) disease Diagnosis not made by lumpectomy or incisional biopsy Currently a candidate for mastectomy and neoadjuvant chemotherapy Primary tumor measurable by breast ultrasound and clinical exam No bilateral breast cancer No high probability for extensive intraductal in situ disease No clinical fixation to the pectoralis major muscle or skin No involvement of the nipple No inflammatory breast cancer No multicentric disease Hormone receptor status: Not specified PATIENT CHARACTERISTICS: Age: 18 and over Sex: Female Menopausal status: Not specified Performance status: Karnofsky 70-100% Life expectancy: At least 6 months Hematopoietic: Platelet count at least 100,000/mm^3 (no thrombocytopenia) No bleeding disorders Hepatic: PT and PTT less than 1.5 times normal INR less than 1.5 times normal Bilirubin no greater than 2.0 mg/dL Transaminases no greater than 2 times normal No coagulopathy No liver disease Renal: BUN less than 30 mg/dL OR Creatinine less than 1.9 mg/dL No renal insufficiency Cardiovascular: No clinically significant heart disease No pacemakers or defibrillators Other: Not pregnant or nursing Negative pregnancy test Fertile patients must use 2 effective methods of contraception No breast implants No prior collagen vascular disease No concurrent mental condition that would preclude study No contraindications to chemotherapy Able to tolerate prone position and breast compression PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics Endocrine therapy: Not specified Radiotherapy: Not specified Surgery: See Disease Characteristics Other: No prior participation in this study More than 30 days since participation in another clinical trial No concurrent participation in another clinical trial No concurrent anticoagulants
Sites / Locations
- Jonsson Comprehensive Cancer Center, UCLA
- St. Joseph Hospital Regional Cancer Center - Orange
- Comprehensive Breast Center of Coral Springs
- Oklahoma University Medical Center at University of Oklahoma Health Sciences Center
- Mroz-Baier Breast Care Center
- Breast Care Specialists, P.C.