Combination Chemotherapy in Treating Women With Breast Cancer Who Have Undergone Surgery
Breast Cancer
About this trial
This is an interventional treatment trial for Breast Cancer focused on measuring stage I breast cancer, stage II breast cancer
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically confirmed newly diagnosed invasive breast cancer Early stage disease Completely resected disease No more than 8 weeks since prior resection Any nodal status Indication for adjuvant chemotherapy No metastatic disease Hormone receptor status: Estrogen receptor negative or weakly positive OR Estrogen receptor positive AND progesterone receptor negative or weakly positive PATIENT CHARACTERISTICS: Age: 18 and over Sex: Female Menopausal status: Not specified Performance status: ECOG 0-2 Life expectancy: Not specified Hematopoietic: WBC greater than 3,000/mm3 Platelet count greater than 100,000/mm3 Hemoglobin greater than 9 g/dL Hepatic: Bilirubin normal AST and ALT no greater than 1.5 times normal Renal: Creatinine no greater than 1.5 times normal Other: Fit to receive study chemotherapy No active uncontrolled infection No other malignancy within the past 10 years except basal cell carcinoma or carcinoma in situ of the cervix No other concurrent medical or psychiatric problems that would preclude study Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: See Disease Characteristics No prior chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior radiotherapy Surgery: See Disease Characteristics
Sites / Locations
- Queen Elizabeth Hospital at University of Birmingham
- Cancer Research UK Clinical Trials Unit - Birmingham
- City Hospital - Birmingham
- Birmingham Heartlands and Solihull NHS Trust -Teaching
- Queen's Hospital, Burton
- Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
- Broomfield Hospital
- Essex County Hospital
- Walsgrave Hospital
- Dorset County Hospital
- Royal Devon and Exeter Hospital
- Princess Royal Hospital
- Hinchingbrooke Hospital
- King George Hospital
- Crosshouse Hospital
- Cookridge Hospital at Leeds Teaching Hospital NHS Trust
- Leeds Cancer Centre at St. James's University Hospital
- St. George's Hospital
- Christie Hospital N.H.S. Trust
- Clatterbridge Centre for Oncology NHS Trust
- James Cook University Hospital
- Northern Centre for Cancer Treatment at Newcastle General Hospital
- Northampton General Hospital NHS Trust
- Nottingham City Hospital NHS Trust
- Peterborough Hospitals Trust
- Derriford Hospital
- Oldchurch Hospital
- Thornbury Hospital
- Cancer Research Centre at Weston Park Hospital
- Royal Shrewsbury Hospital
- West Suffolk Hospital
- Torbay Hospital
- Walsall Manor Hospital
- Sandwell General Hospital
- Good Hope Hospital Trust
- Worcester Royal Hospital
- Western General Hospital
- Beatson Oncology Centre
- Royal Infirmary - Castle
- Velindre Cancer Center at Velinde Hospital
- Hairmyres Hospital
- Hull Royal Infirmary
- Queen Elizabeth Hospital
- Glan Clywd District General Hospital
- Singleton Hospital
- Morriston Hospital NHS Trust