FR901228 in Treating Patients With Myelodysplastic Syndrome, Acute Myeloid Leukemia, or Non-Hodgkin's Lymphoma

DISEASE CHARACTERISTICS: One of the following diagnoses: Histologically confirmed refractory or relapsed acute myeloid leukemia (AML) Failed anthracycline-based chemotherapy Ineligible for or refused allogeneic stem cell transplantation Elderly patients with newly diagnosed AML Ineligible for or refused standard chemotherapy Histologically confirmed high-risk myelodysplastic syndromes Eligible subtypes include: Refractory anemia with excess blasts (RAEB) RAEB in transformation Chronic myelomonocytic leukemia Ineligible for or refused allogeneic bone marrow transplantation Histologically confirmed intermediate-grade non-Hodgkin's lymphoma (NHL) Relapsed after high-dose therapy OR Ineligible for allogeneic or autologous stem cell transplantation Evaluable lesions by radiologic study or physical examination Histologically confirmed follicular NHL Progressed after anthracycline-based chemotherapy and rituximab Evaluable lesions by radiologic study or physical examination NOTE: A new classification scheme for adult non-Hodgkin's lymphoma has been adopted by PDQ. The terminology of "indolent" or "aggressive" lymphoma will replace the former terminology of "low", "intermediate", or "high" grade lymphoma. However, this protocol uses the former terminology. PATIENT CHARACTERISTICS: Age 18 and over Performance status Karnofsky 60-100% Life expectancy Not specified Hematopoietic Not specified Hepatic Bilirubin no greater than 1.5 mg/dL (unless due to Gilbert's syndrome) SGOT and SGPT less than 2 times upper limit of normal Renal Creatinine no greater than 1.5 mg/dL OR Creatinine clearance at least 60 mL/min Cardiovascular Cardiac ejection fraction greater than 50% No cardiac hypertrophy No known conduction heart disease No New York Heart Association class III or IV heart disease that would make it difficult to assess patient during study participation No significant prior heart disease No significant prior secondary or tertiary heart block No significant prior atrial or ventricular arrhythmia requiring therapeutic intervention or antiarrhythmics for rate control Pulmonary No severe debilitating pulmonary disease that would make it difficult to assess patient during study participation Other Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception during and for 1 month after study participation Potassium ≥ 4.0 mmol/L (supplementation allowed) Magnesium ≥ 2.0 mg/dL (supplementation allowed) No other concurrent active malignancy except basal cell skin cancer No other concurrent significant co-morbidity that would make it difficult to assess patient during study participation PRIOR CONCURRENT THERAPY: Biologic therapy See Disease Characteristics At least 2 weeks since prior epoetin alfa or filgrastim (G-CSF) At least 4 weeks since prior cytokines No concurrent immunotherapy Chemotherapy See Disease Characteristics At least 4 weeks since prior systemic chemotherapy No other concurrent chemotherapy Endocrine therapy Not specified Radiotherapy At least 4 weeks since prior radiotherapy No concurrent radiotherapy Surgery Not specified Other No other concurrent investigational agents No concurrent drugs that may prolong the QTc interval FR901228 (depsipeptide) may be administered after a 5-half-life washout period following the use of these drugs