Combination Chemotherapy in Treating Patients With Chronic Lymphocytic Leukemia or Lymphocytic Lymphoma
Leukemia, Lymphoma
About this trial
This is an interventional treatment trial for Leukemia focused on measuring refractory chronic lymphocytic leukemia, recurrent small lymphocytic lymphoma
Eligibility Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed chronic lymphocytic leukemia (CLL) or B-cell small lymphocytic lymphoma (SLL) CLL is defined as: Persistent lymphocytosis greater than 5,000/mm^3 CD19/CD5/CD23 positive Kappa or lambda light chain restriction Refractory to or disease progression after 1 or 2 prior treatment regimens Retreatment with oral chlorambucil is allowed and considered a second regimen At least one of the chlorambucil treatments must be for 3 months or longer At least 4 courses of cyclophosphamide, vincristine, and prednisone with or without doxorubicin allowed Patients may have received prior fludarabine as first- or second-line therapy if there is evidence of at least partial response and time to progression after initial fludarabine therapy was at least 12 months No CNS involvement by lymphoma PATIENT CHARACTERISTICS: Age 18 and over Performance status ECOG 0-2 OR Karnofsky 60-100% Life expectancy More than 3 months Hematopoietic See Disease Characteristics Absolute neutrophil count at least 1,000/mm^3 Platelet count at least 100,000/mm^3 No autoimmune hemolytic anemia or thrombocytopenia secondary to CLL or SLL requiring ongoing therapy with prednisone or other immunosuppressive agents Hepatic Bilirubin normal AST and ALT no greater than 2.5 times upper limit of normal Renal Creatinine normal OR Creatinine clearance at least 60 mL/min Cardiovascular No symptomatic congestive heart failure No unstable angina pectoris No cardiac arrhythmia Pulmonary DLCO greater than 60% predicted FEV_1 greater than 70% predicted No significant underlying pulmonary disease Other No other malignancy within the past 5 years except adequately treated basal cell skin cancer or carcinoma in situ of the cervix No insulin-dependent diabetes mellitus No other uncontrolled concurrent illness No ongoing or active infection No pre-existing peripheral neuropathy grade 2 or greater No psychiatric illness or social situation that would preclude study compliance No prior allergic reactions to compounds of similar chemical or biological composition to UCN-01 or other agents in this study Not pregnant or nursing Negative pregnancy test Fertile patients must use effective contraception PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy See Disease Characteristics At least 4 weeks since prior chemotherapy and recovered Endocrine therapy See Hematopoietic Radiotherapy No prior mediastinal radiation At least 4 weeks since prior radiotherapy and recovered Surgery Not specified Other No other concurrent investigational agents No concurrent combination antiretroviral therapy for HIV-positive patients
Sites / Locations
- McMaster Children's Hospital at Hamilton Health Sciences
- London Health Sciences Centre
- Princess Margaret Hospital at University Health Network